circRNA basic information
circBase ID: hsa_circ_0076248
Name: hsa_circ_ZFAND3
Synonym: -
Host Gene: hsa-miR-181a
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: U251, U87, HEB
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SIRT1
Associated microRNA: hsa-miR-181a
Biological function: promotes proliferation and invasion
Molecular mechanism: sponging hsa-miR-181a to modulate SIRT1 expression
Survival: -
Supported No.:
 1
Description:

Our study sheds light on the regulatory mechanism of hsa_circ_0076248 in glioma growth and invasion via sponging miR-181a, which downregulates the SIRT1 expression and also suggests that hsa_circ_0076248, miR-181a, and SIRT1 may serve as potential therapeutic targets for glioma.
Other information
Title:

Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression.

Journal: J Cell Biochem
Published: 2018/12/7
PubMed ID: 30506951