circRNA basic information
circBase ID: -
Name: hsa_circ_PCNXL2
Synonym: circPCNXL2
Host Gene: hsa-miR-153
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human RCC cell lines (A498, 786-O, ACHN, Caki-1), immortalized normal renal epithelial cell line (HK-2)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: ZEB2
Associated microRNA: hsa-miR-153
Biological function: promote the proliferation and invasion
Molecular mechanism: upregulating ZEB2
Survival: poor
Supported No.:
 1
Description:

we demonstrated that circPCNXL2 could regulate RCC cells proliferation and invasion by miR-153/ZEB2 axis, suggesting circPCNXL2 might serve as a potential therapeutic target for ccRCC treatment.
Other information
Title:

CircPCNXL2 sponges miR-153 to promote the proliferation and invasion of renal cancer cells through upregulating ZEB2.

Journal: Cell Cycle
Published: 2018/11/30
PubMed ID: 30488762