circRNA basic information
circBase ID: hsa_circ_0006427
Name: hsa_circ_BCAR3
Synonym: -
Host Gene: hsa-miR-6783-3p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human LUAD cell lines (H1299, A549, SPC-A1, Calu3), human normal lung epithelial cell line (BEAS-2B)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: DKK1
Associated microRNA: hsa-miR-6783-3p
Biological function: suppressed cell proliferation, migration and invasion
Molecular mechanism: circ_0006427 positively regulate DKK1 in LUAD by sponging hsa-miR-6783-3p. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis and western blot analysis revealed that circ_0006427 inactivated Wnt/beta-catenin signaling pathway by upregulating DKK1.
Survival: better
Supported No.:
 1
Description:

Our study revealed that circ_0006427 suppressed lung adenocarcinoma progression through regulating miR-6783-3p/DKK1 axis.
Other information
Title:

CircRNA has_circ_0006427 suppresses the progression of lung adenocarcinoma by regulating miR-6783-3p/DKK1 axis and inactivating Wnt/beta-catenin signaling pathway.

Journal: Biochem Biophys Res Commun
Published: 2018/11/25
PubMed ID: 30470570