circRNA basic information
circBase ID: -
Name: hsa_circ_FECR1
Synonym: -
Host Gene: hsa-miR-584
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: lung cancer cell lines (NCI-H446, NCIH1688, NCI-H460, NCI-H1299, A549, PC-9, Calu-1, HCC-827, NCI-H2170, SKMES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK1
Associated microRNA: hsa-miR-584
Biological function: promotes tumor metastasis
Molecular mechanism: suppressor miR584-3p, leading to the activation of the Rho Associated Coiled-Coil Containing Protein Kinase 1 gene (ROCK1)
Survival: -
Supported No.:
 1
Description:

This study identifies_LI1_xonic circular RNAs as a new oncogenic driver that promotes tumor metastasis through the miR584-ROCK1 pathway. Importantly, serum exosomal FECR1 may serve as a promising biomarker to track disease progression of SCLC.
Other information
Title:

FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer.

Journal: Clin Cancer Res
Published: 2018/11/16
PubMed ID: 30429198