circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_102171
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PTC cell lines (TPC-1, NPA87, KAT-5), normal cell line (Nthy-ori3_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CTNNBIP1, beta-catenin, TCF3, TCF4, LEF1
Associated microRNA: -
Biological function: promoted cell proliferation, migration and invasion while inhibits apoptosis
Molecular mechanism: interacted with CTNNBIP1 to block its interaction with the beta-catenin/TCF3/TCF4/LEF1 complex, leading to activation of Wnt/beta-catenin pathway
Survival: -
Supported No.:
 1
Description:

CircRNA_102171 overexpression promotes PTC progression through activating Wnt/beta-catenin pathway in a CTNNBIP1-dependent way.
Other information
Title:

CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of beta-catenin pathway.

Journal: J Exp Clin Cancer Res
Published: 2018/11/15
PubMed ID: 30424816