circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: -
Host Gene: hsa-miR-548g
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human gastric epithelial mucosa cell line (GSE-1), human GC cell lines (SGC-7901, BGC-823, MKN-28, AGS, MGC-803, MKN-45)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: RUNX1, YBX1
Associated microRNA: hsa-miR-548g
Biological function: inhibited GC cell proliferation, migration and invasion
Molecular mechanism: circFAT1(e2) acts as a sponge of microRNA-549g(hsa-miR-548g) and regulates the expression of tumor suppressor RUNX1 in GC cells. Moreover, we found that nucleus-located circFAT1(e2) could directly interact with Y-box binding protein-1 (YBX1) and inhibit its function
Survival: better
Supported No.:
 1
Description:

The circFAT1(e2) may play a role as a tumor suppressor in GC cells by regulating the miR-548g/RUNX1 axis in the cytoplasm and targeting YBX1 in the nucleus.
Other information
Title:

A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus.

Journal: Cancer Lett
Published: 2018/11/13
PubMed ID: 30419346