circRNA basic information
circBase ID: -
Name: hsa_circ_ACR
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: cardiovascular disease
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ACR, Pink1, FAM65B
Associated microRNA: -
Biological function: inhibits autophagy and cell death
Molecular mechanism: ACR activates Pink1 expression through directly binding to Dnmt3B and blocking Dnmt3B-mediated DNA methylation of Pink1 promoter. Pink1 suppresses autophagy and Pink1 transgenic mice show reduced myocardial infarction sizes. Further, we find that FAM65B is a downstream target of Pink1 and Pink1 phosphorylates FAM65B at serine 46. Phosphorylated FAM65B inhibits autophagy and cell death in the heart.
Survival: -
Supported No.:
 1
Description:

Our findings reveal a novel role for the circRNA in regulating autophagy and ACR-Pink1-FAM65B axis as a regulator of autophagy in the heart will be potential therapeutic targets in treatment of cardiovascular diseases.
Other information
Title:

The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway.

Journal: Cell Death Differ
Published: 2018/10/24
PubMed ID: 30349076