circRNA basic information
circBase ID: hsa_circ_0135889
Name: hsa_circ_AGO2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 219
DO name: colon cancer
Disease details: colon cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human embryonic kidney cells (HEK293T, CRL-1573), gastric cancer cell lines (AGS), cervical cancer cell lines (HeLa), colon cancer cell lines (HCT-116, LoVo), prostate cancer cell lines (PC-3), neuroblastoma (SH-SY5Y, SK-N-SH)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HuR
Associated microRNA: -
Biological function: promote growth, invasion, and metastasis of cancer cells
Molecular mechanism: facilitating HuR-repressed functions of AGO3-miRNA complexes
Survival: poor
Supported No.:
 1
Description:

These results indicate that oncogenic circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.
Other information
Title:

Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.

Journal: Cell Death Differ
Published: 2018/10/21
PubMed ID: 30341421