circRNA basic information
circBase ID: -
Name: hsa_circ_PRMT5
Synonym: circPRMT5
Host Gene: hsa-miR-30c
 
 
 
Disease basic information
DO ID:
 4006
DO name: bladder urothelial carcinoma
Disease details: urothelial carcinoma of the bladder
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: UCB cell lines (T24, TCC-SUP, 5637, UM-UC-3), nontumorous bladder cell line (SV-HUC-1)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: SNAIL1
Associated microRNA: hsa-miR-30c
Biological function: promotes Metastasis
Molecular mechanism: Sponging hsa-miR-30c to Induce Epithelial-Mesenchymal Transition
Survival: poor
Supported No.:
 1
Description:

CircPRMT5 exerts critical roles in promoting UCB cells EMT and/or aggressiveness and is a prognostic biomarker of the disease, suggesting that circPRMT5 may serve as an exploitable therapeutic target for patients with UCB.
Other information
Title:

PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial-Mesenchymal Transition.

Journal: Clin Cancer Res
Published: 2018/10/12
PubMed ID: 30305293