circRNA basic information
circBase ID: -
Name: mmu_circ_Rar1
Synonym: -
Host Gene: mmu-miR-671
 
 
 
Disease basic information
DO ID:
 3602
DO name: toxic encephalopathy
Disease details: lead-induced neuronal cell apoptosis
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: apoptosis-associated factors caspase8 and p38
Associated microRNA: mmu-miR-671
Biological function: promoted neuronal apoptosis
Molecular mechanism: induced the upregulation of apoptosis-associated factors caspase8 and p38; miRNA sponge
Survival: -
Supported No.:
 1
Description:

lncRpa and circRar1 induced the upregulation of apoptosis-associated factors caspase8 and p38 at the mRNA and protein levels via modulation of their common target microRNA miR-671.

Other information
Title:

A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis.

Journal: Arch Toxicol
Published: 2016/9/9
PubMed ID: 27604105