circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-124
 
 
 
Disease basic information
DO ID:
9351
DO name: diabetes mellitus
Disease details: diabetes
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-124
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
2
Description:

circHIPK3 are highly abundant in serum from diabetes patients who suffered from neuropathic pain and in dorsal root ganglion from STZ-induced diabetes rats. Upregulation of circHIPK3 was positively associated with grade neuropathic pain in patients with type 2 diabetes. Silencing circHIPK3 alleviated neuropathic pain in diabetic rats, which was involved in neuroinflammation. Further mechanistic investigation demonstrated that circHIPK3 interacted with miR-124 and negatively regulated its expression. MiR-124 inhibitor can reverse circHIPK3 knockdown-mediated alleviation of neuropathic pain and inhibition of neuroinflammation in diabetic rats.

Other information
Title:

Intrathecal circHIPK3 shRNA alleviates neuropathic pain in diabetic rats.

Journal: Biochem Biophys Res Commun
Published: 2018/10/6
PubMed ID: 30286957