circRNA basic information
circBase ID: -
Name: hsa_circ_ANRIL
Synonym: -
Host Gene: hsa-miR-4659a, hsa-miR-4659b, hsa-miR-3184-3p, hsa-miR-5571-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HEK-293
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4659a, hsa-miR-4659b, hsa-miR-3184-3p, hsa-miR-5571-5p
Biological function: conferring atheroprotection
Molecular mechanism: binds to pescadillo homologue 1 (PES1), miRNA sponge
Survival: -
Supported No.:
 4
Description:

CircANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis.
Other information
Title:

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.

Journal: Nat Commun
Published: 2016/8/20
PubMed ID: 27539542