circRNA basic information
circBase ID: -
Name: hsa_circ_SPG21
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

CircSEMA4B serves as a miR-431 sponge to compete with SFRP1 or GSK-3beta for miR-431 binding, thus inhibiting IL-5beta-induced degenerative process in NPCs through Wnt signaling.
Other information
Title:

CircSEMA4B targets miR-431 modulating IL-1beta-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway.

Journal: Biochim Biophys Acta Mol Basis Dis
Published: 2018/9/27
PubMed ID: 30251693