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PART A

Messenger RNA Expression Microarray of Diffuse Gliomas and Controls

Platform: Agilent

Total number of samples:

Batch 1, 225 (5 controls and 220 diffuse gliomas)

Batch 2, 85 (diffuse gliomas)

Publications:

1. W Yan, W Zhang, G You, J Zhang, L Han, Z Bao, Y Wang, Y Liu, C Jiang, C Kang, Y You, and T Jiang, Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group[J]. Neuro Oncol, 2012. 14(12): 1432-40. (Methods and analysis procedures were included in this paper)

2. Y Sun, W Zhang, D Chen, Y Lv, J Zheng, H Lilljebjorn, L Ran, Z Bao, C Soneson, H O Sjogren, L G Salford, J Ji, P J French, T Fioretos, T Jiang, and X Fan, A glioma classification scheme based on coexpression modules of EGFR and PDGFRA[J]. Proc Natl Acad Sci U S A, 2014. 111(9): 3538-43.

Data Batch:

1. Batch 1 download, Clinical information (last updated: 2012-01-01)

2. Batch 2 download, Clinical information (last updated: 2013-01-01)

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PART B

MicroRNA Expression Microarray of Diffuse Gliomas

Platform: Agilent

Total number of samples: 198 diffuse gliomas

Publications:

1. W Zhang, J Zhang, W Yan, G You, Z Bao, S Li, C Kang, C Jiang, Y You, Y Zhang, C C Chen, S W Song, and T Jiang, Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme[J]. Cancer, 2013. 119(4): 814-24. (Methods and analysis procedures were included in this paper)

2. W Yan, R Li, Y Liu, P Yang, Z Wang, C Zhang, Z Bao, W Zhang, Y You, and T Jiang, MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis[J]. Oncotarget, 2014. 5(24): 12908-15.

3. W Yan, Y Liu, P Yang, Z Wang, Y You, and T Jiang, MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype[J]. Oncotarget, 2015. 6(13): 11676-82.

Data Batch:

1. Data download, Clinical information (last updated: 2012-01-01)

 

PART C

DNA methylation Microarray of Diffuse Gliomas

Platform: Illunima Human Methylation 27K

Total number of samples: 151 diffuse gliomas

Publications:

1. W Zhang, W Yan, G You, Z Bao, Y Wang, Y Liu, Y You, and T Jiang, Genome-wide DNA methylation profiling identifies ALDH1A3 promoter methylation as a prognostic predictor in G-CIMP- primary glioblastoma[J]. Cancer Lett, 2013. 328(1): 120-5. (Methods and analysis procedures were included in this paper)

Data Batch:

1. Data download, Clinical information (last updated: 2012-01-01)

 

PART D

RNAsequencing of Diffuse Gliomas

Platform: Illunima Hiseq 2000

Total number of samples:

Batch 1: 272 diffuse gliomas

Batch 2: 53 diffuse gliomas

Publications:

1. Z S Bao, H M Chen, M Y Yang, C B Zhang, K Yu, W L Ye, B Q Hu, W Yan, W Zhang, J Akers, V Ramakrishnan, J Li, B Carter, Y W Liu, H M Hu, Z Wang, M Y Li, K Yao, X G Qiu, C S Kang, Y P You, X L Fan, W S Song, R Q Li, X D Su, C C Chen, and T Jiang, RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas[J]. Genome Res, 2014. 24(11): 1765-73. (Methods and analysis procedures were included in this paper)

Data Batch:

1. Batch 1 raw data in NCBI-SRA: SRP027383 (last updated: 2013-01-01)

2. Batch 2 raw data in NCBI-SRASRP091303 (last updated: 2016-10-14)

3. Gene expression download, Clinical information (last updated: 2017-04-09)