title	circrna_id	circ_rna_name	circrna_synonyms	disease_do_id	disease_do_name	disease_details	method	expression_pattern	description	support_count
Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.	-	hsa_circ_ANRIL	-	DOID:1936	atherosclerosis	atherosclerosis	RNA-seq	down-regulated	"ANRIL encodes a heterogeneous species of rare RNA transcripts. Moreover, we identified novel, circular ANRIL isoforms (cANRIL) whose expression correlated with INK4/ARF transcription and ASVD risk."	4
Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.	-	hsa_circ_ANRIL	-	DOID:1936	atherosclerosis	atherosclerosis	RNA-seq	down-regulated	"ANRIL encodes a heterogeneous species of rare RNA transcripts. Moreover, we identified novel, circular ANRIL isoforms (cANRIL) whose expression correlated with INK4/ARF transcription and ASVD risk."	4
"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."	hsa_circ_0024169	hsa_circ_CUL5	circ0817	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, RNA-seq"	down-regulated	We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation.	1
"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."	hsa_circ_0002138	hsa_circ_USP3	circ3204	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, RNA-seq"	down-regulated	We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation.	2
"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."	hsa_circ_0000523	hsa_circ_METTL3	circ6229	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, RNA-seq"	down-regulated	We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation.	4
"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."	-	hsa_circ_TNS4	circ7374	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, RNA-seq"	up-regulated	We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation.	1
"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."	-	-	circ7780	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, RNA-seq"	down-regulated	We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation.	1
Using circular RNA as a novel type of biomarker in the screening of gastric cancer.	hsa_circ_0000140	hsa_circ_KIAA0907	hsa_circ_002059	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	"Hsa_circ_0000140 lower expression levels were significantly correlated with distal metastasis, TNM stage, gender and age."	3
Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/beta-catenin pathway.	-	hsa_circ_ITCH	"cir-ITCH, circ-ITCH"	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	RT-qPCR	down-regulated	"ITCH hyper expression promotes ubiquitination and degradation of phosphorylated Dvl2, thereby inhibiting the Wnt/beta-catenin pathway. These results indicate that cir-ITCH may have an inhibitory effect on ESCC by regulating the Wnt pathway."	1
cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/beta-catenin pathway.	-	hsa_circ_ITCH	"cir-ITCH, circ-ITCH"	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	down-regulated	"Cir-ITCH expression was typically down-regulated in CRC compared to the peritumoral tissue. This result, as well as several follow-up experi- ments, showed that cir-ITCH could increase the level of ITCH, which is involved in the inhibi- tion of the Wnt/beta-catenin pathway."	1
Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis.	-	hsa_circ_KLDHC10	-	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, RNA-seq"	up-regulated	expression levels of circ-KLDHC10 were significantly increased in cancer serum than those in NS.	1
"The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells."	-	-	mmu_circ_0001878	DOID:9351	diabetes mellitus	diabetes	RT-qPCR	up-regulated	"We further identified a new target Myrip in the Cdr1as/miR-7 pathway that regulates insulin granule secretion, and also another target Pax6 that enhances insulin transcription."	1
Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma.	hsa_circ_0001649	hsa_circ_SHPRH	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	down-regulated	Hsa_circ_0001649 was significantly downregulated in hepatocellular carcinoma (HCC). Our findings indicate hsa_circ_0001649 might serve as a novel potential biomarker for HCC and may function in tumorigenesis and metastasis of HCC.	4
Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis.	-	hsa_circ_FOXO3	-	DOID:1612	breast cancer	breast cancer	RT-qPCR	down-regulated	"The breast tumor tissues expressed low levels of circ-Foxo3, Foxo3P and Foxo3 compared with normal tissues. We found that the ectopic expression of the Foxo3P, Foxo3 circular RNA and Foxo3 mRNA could all suppress tumor growth and cancer cell proliferation and survival."	3
Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:0060108	brain glioma	glioma	RT-qPCR	down-regulated	The axis miR-671-5p/CDR1-AS/CDR1/VSNL1 is functionally altered in GBM cells and is involved in the modification of their biopathological profile.	2
A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223.	-	-	mm9-circ-012559	DOID:6000	congestive heart failure	congestive heart failure	RT-qPCR	down-regulated	Heart-related circRNA inhibits cardiomyocytes hypertrophy through targeting miR-223 and apoptosis repressor with CARD domain.	1
Circular RNA expression alterations are involved in OGD/R-induced neuron injury.	-	-	mmu-circRNA-015947	DOID:936	brain disease	ischemia reperfusion injury	RT-qPCR	up-regulated	This research suggests that the overlapping expression of mmu-circRNA-015947 might be involved in the process of cerebral IRI and presents a novel molecular target for clinical therapy.	1
Circular RNA in blood corpuscles combined with plasma protein factor for early prediction of pre-eclampsia.	-	-	circ_101222	DOID:10591	pre-eclampsia	preeclampsia	"RT-qPCR, microarray"	up-regulated	Plasma protein endoglin in combination with circ_101222 strengthened the predictive power for pre-eclampsia.	1
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.	-	mmu_circ_FOXO3	-	DOID:1612	breast cancer	breast cancer	RT-qPCR	down-regulated	The circular RNA circ-Foxo3 was highly expressed in noncancer cells and were associated with cell cycle progression. Silencing endogenous circ-Foxo3 promoted cell proliferation.	1
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2.	-	mmu_circ_FOXO3	-	DOID:1909	melanoma	melanoma	RT-qPCR	down-regulated	The circular RNA circ-Foxo3 was highly expressed in noncancer cells and were associated with cell cycle progression. Silencing endogenous circ-Foxo3 promoted cell proliferation.	1
Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses.	-	hsa_circ_FOXO3	-	DOID:114	heart disease	cardiac senescence	RT-qPCR	up-regulated	We also found that silencing circ-Foxo3 inhibited senescence of mouse embryonic fibroblasts and that ectopic expression of circ-Foxo3 induced senescence.	1
Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses.	-	mmu_circ_FOXO3	-	DOID:114	heart disease	cardiac senescence	RT-qPCR	up-regulated	We also found that silencing circ-Foxo3 inhibited senescence of mouse embryonic fibroblasts and that ectopic expression of circ-Foxo3 induced senescence.	2
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:0060108	brain glioma	glioma	RNA-seq	down-regulated	"There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function."	2
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_ATRNL1	-	DOID:0060108	brain glioma	glioma	RNA-seq	down-regulated	"There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_AKT3	-	DOID:0060108	brain glioma	glioma	RNA-seq	down-regulated	"There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_SPTAN1	-	DOID:0060108	brain glioma	glioma	RNA-seq	down-regulated	"There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_ZNF483	-	DOID:0060108	brain glioma	glioma	RNA-seq	down-regulated	"There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_RIMS1	-	DOID:0060108	brain glioma	glioma	"RT-qPCR, RNA-seq"	down-regulated	"There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_FKBP8	-	DOID:0060108	brain glioma	glioma	"RT-qPCR, RNA-seq"	down-regulated	"There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function."	2
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_UNC13C	-	DOID:0060108	brain glioma	glioma	RNA-seq	down-regulated	"There are about 468 circRNAs, such as circ_CDR1, circ_ATRNL1, circ_AKT3, circ_SPTAN1, circ_ZNF483, circ_RIMS1, circ_FKBP8, circ_UNC13C, that are more highly expressed in normal tissue than in GBM with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that most of the highly expressed circRNAs are important factor in maintaining normal physiological function."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_COL1A2	-	DOID:0060108	brain glioma	glioma	RNA-seq	up-regulated	"There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_PTN	-	DOID:0060108	brain glioma	glioma	RNA-seq	up-regulated	"There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM."	3
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_VCAN	-	DOID:0060108	brain glioma	glioma	"RT-qPCR, RNA-seq"	up-regulated	"There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM."	3
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_SMO	-	DOID:0060108	brain glioma	glioma	RNA-seq	up-regulated	"There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_PLOD2	-	DOID:0060108	brain glioma	glioma	RNA-seq	up-regulated	"There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM."	1
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_GLIS3	-	DOID:0060108	brain glioma	glioma	RNA-seq	up-regulated	"There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM."	2
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_EPHB4	-	DOID:0060108	brain glioma	glioma	RNA-seq	up-regulated	"There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM."	3
Circular RNA profile in gliomas revealed by identification tool UROBORUS.	-	hsa_circ_CLIP2	-	DOID:0060108	brain glioma	glioma	RNA-seq	up-regulated	"There are eight circRNAs, such as circ_COL1A2, circ_PTN, circ_VCAN, circ_SMO, circ_PLOD2, circ_GLIS3, circ_EPHB4, circ_CLIP2, that are more highly expressed in GBM than in normal tissues with a q value < 0.05 (Wilcoxon rank-sum test and Benjamini-Hochberg correction), indicating that these eight circRNAs could be potential biomarkers for GBM."	3
Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances.	hsa_circ_0001451	hsa_circ_FBXW7	hsa_circ_001988	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, RNA-seq"	down-regulated	The expression of hsa_circ_001988 was signi cantly correlated with differentiation and perineural invasion.	3
Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 Sponge in Human Cartilage Degradation.	hsa_circ_0023404	hsa_circ_CER	circRNA_100876	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, microarray"	up-regulated	We demonstrated that circRNA-CER regulated MMP13 expression and participated in the process of chondrocyte ECM degradation.	1
The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:5844	myocardial infarction	myocardial Infarction	RT-qPCR	up-regulated	"Cdr1as also functioned as a powerful miR-7a sponge in myocardial cells, and showed regulation on the protective role of miR-7a in myocardial infarction (MI) injury, involving the function of miR-7a targets, PARP and SP1."	1
Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations.	-	-	f-circRNA	DOID:1240	leukemia	leukemia	"RT-qPCR, RNA-seq"	up-regulated	"F-circRNAs contribute to cellular transformation, promote cell viability and resistance upon therapy, and have tumor-promoting properties in in_ivo models. Our work expands the current knowledge regarding molecular mechanisms involved in cancer onset and progression, with potential diagnostic and therapeutic implications."	1
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.	hsa_circ_0000284	hsa_circ_HIPK3	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"A subsequent cell proliferation assay indicated that the downregulation of circHIPK3, but not HIPK3 mRNA, significantly suppressed cell growth in different cell types. Consistent with this result from the siRNA knockdown experiments, we observed that cell proliferation was significantly suppressed on the knockdown of circHIPK3 expression in HEK-293T cells via CRISPR/Cas9 technology."	6
Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer.	hsa_circ_0000677	hsa_circ_ABCC1	circRNA_001569	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	up-regulated	hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer.	2
Circular RNA expression in basal cell carcinoma.	hsa_circ_0075828	hsa_circ_LINC00340	hsa_circRNA_104083	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	3
Circular RNA expression in basal cell carcinoma.	hsa_circ_0075825	hsa_circ_LINC00340	hsa_circRNA_104081	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	3
Circular RNA expression in basal cell carcinoma.	hsa_circ_0008732	hsa_circ_BNC2	hsa_circRNA_104738	DOID:2513	basal cell carcinoma	basal cell carcinoma	"RT-qPCR, microarray"	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	2
Circular RNA expression in basal cell carcinoma.	hsa_circ_0075829	hsa_circ_LINC00340	hsa_circRNA_104084	DOID:2513	basal cell carcinoma	basal cell carcinoma	"RT-qPCR, microarray"	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	3
Circular RNA expression in basal cell carcinoma.	hsa_circ_0001370	hsa_circ_YEATS2	hsa_circRNA_001830	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	1
Circular RNA expression in basal cell carcinoma.	hsa_circ_0005795	hsa_circ_LPXN	hsa_circRNA_100823	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	2
Circular RNA expression in basal cell carcinoma.	hsa_circ_0004777	hsa_circ_SOX13	hsa_circRNA_100432	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	1
Circular RNA expression in basal cell carcinoma.	hsa_circ_0080189	hsa_circ_TNS3	hsa_circRNA_104370	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	1
Circular RNA expression in basal cell carcinoma.	hsa_circ_0086419	hsa_circ_BNC2	hsa_circRNA_104739	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	2
Circular RNA expression in basal cell carcinoma.	hsa_circ_0005912	hsa_circ_FIP1L1	hsa_circRNA_103643	DOID:2513	basal cell carcinoma	basal cell carcinoma	"RT-qPCR, microarray"	up-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	1
Circular RNA expression in basal cell carcinoma.	hsa_circ_0022383	hsa_circ_FADS2	hsa_circRNA_100833	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	down-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	2
Circular RNA expression in basal cell carcinoma.	hsa_circ_0022392	hsa_circ_FADS2	hsa_circRNA_100834	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	down-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	2
Circular RNA expression in basal cell carcinoma.	hsa_circ_0005085	hsa_circ_ASAP2	hsa_circRNA_102612	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	down-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	1
Circular RNA expression in basal cell carcinoma.	hsa_circ_0015449	hsa_circ_SOAT1	hsa_circRNA_100410	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	down-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	1
Circular RNA expression in basal cell carcinoma.	hsa_circ_0072387	hsa_circ_HMGCS1	hsa_circRNA_103829	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	down-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	1
Circular RNA expression in basal cell carcinoma.	hsa_circ_0046449	hsa_circ_TBCD	hsa_circRNA_102246	DOID:2513	basal cell carcinoma	basal cell carcinoma	microarray	down-regulated	We identified 23 upregulated and 48 downregulated circRNAs with 354 miRNA response elements capable of sequestering miRNA target sequences of the basal cell carcinoma (BCC) miRNome. The present study describes a variety of circRNAs that are potentially involved in the molecular pathogenesis of BCC.	1
Circular RNA: a novel biomarker for progressive laryngeal cancer.	-	-	hsa_circRNA_100855	DOID:2876	laryngeal squamous cell carcinoma	laryngeal squamous cell carcinoma	"RT-qPCR, microarray"	up-regulated	"The hsa_circRNA_100855 level was signicantly higher in laryngeal squamous cell cancer (LSCC) than in the corresponding adjacent non-neoplastic tissues. Patients with T3-4 stage, neck nodal metastasis or advanced clinical stage had higher hsa_circRNA_100855 expression."	1
Circular RNA: a novel biomarker for progressive laryngeal cancer.	-	-	hsa_circRNA_104912	DOID:2876	laryngeal squamous cell carcinoma	laryngeal squamous cell carcinoma	"RT-qPCR, microarray"	down-regulated	"The hsa_circRNA_104912 level was signicantly lower in laryngeal squamous cell cancer (LSCC) than in corresponding adjacent non-neoplastic tissues. Patients with T3-4 stage, neck nodal metastasis, poor differentiation or advanced clinical stage had a lower hsa_circRNA_104912 expression. Overall, our data suggest that circRNAs play an important role in the tumorigenesis of LSCC and may serve as novel and stable biomarkers for the diagnosis and progress of LSCC."	1
"Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development."	hsa_circ_0005075	hsa_circ_EIF4G3	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, microarray"	up-regulated	"Hsa_circ_0005075 expression shows significant association with some clinicopathological factors of hepatocellular carcinoma (HCC) patients, and may serve as a novel potential biomarker for HCC diagnosis."	4
Circular RNA expression in cutaneous squamous cell carcinoma.	hsa_circ_0022383	hsa_circ_FADS2	hsa_circRNA_100833	DOID:3151	skin squamous cell carcinoma	cutaneous squamous cell carcinoma	"RT-qPCR, microarray"	down-regulated	"Regarding the top down-regulated circRNAs, hsa_circ_0022392 and hsa_circ_0022383 are both spliced from Fatty Acid Desaturase 2 (FADS2), which is localized at the cancer genomic hotspot 11q13 locus and codes for an enzyme with ?_6 and ?_8-desaturase activity necessary for normal eicosanoid precursor synthesis previously shown in human breast 19 cancer cells."	3
Circular RNA expression in cutaneous squamous cell carcinoma.	hsa_circ_0022392	hsa_circ_FADS2	hsa_circRNA_100834	DOID:3151	skin squamous cell carcinoma	cutaneous squamous cell carcinoma	"RT-qPCR, microarray"	down-regulated	"Regarding the top down-regulated circRNAs, hsa_circ_0022392 and hsa_circ_0022383 are both spliced from Fatty Acid Desaturase 2 (FADS2), which is localized at the cancer genomic hotspot 11q13 locus and codes for an enzyme with ?_6 and ?_8-desaturase activity necessary for normal eicosanoid precursor synthesis previously shown in human breast 19 cancer cells."	3
Circular RNA expression in cutaneous squamous cell carcinoma.	hsa_circ_0070933	hsa_circ_LARP1B	hsa_circRNA_103736	DOID:3151	skin squamous cell carcinoma	cutaneous squamous cell carcinoma	"RT-qPCR, microarray"	up-regulated	"Both of the two most up-regulated circRNAs in this study, hsa_circ_0070933 and 18 hsa_circ_0070934, are spliced from La Ribonucleoprotein Domain Family, Member 1B (LARP1B)."	5
Circular RNA expression in cutaneous squamous cell carcinoma.	hsa_circ_0070934	hsa_circ_LARP1B	hsa_circRNA_103737	DOID:3151	skin squamous cell carcinoma	cutaneous squamous cell carcinoma	"RT-qPCR, microarray"	up-regulated	"Both of the two most up-regulated circRNAs in this study, hsa_circ_0070933 and 18 hsa_circ_0070934, are spliced from La Ribonucleoprotein Domain Family, Member 1B (LARP1B)."	5
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_CDR1as	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	up-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_004775	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	up-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_007687	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	up-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_013216	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	up-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_010567	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	up-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_015506	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	up-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_001135	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	down-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_002007	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	down-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_004768	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	down-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_008398	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	down-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_008640	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	down-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Microarray Expression Profile of Circular RNAs in Heart Tissue of Mice with Myocardial Infarction-Induced Heart Failure.	-	-	mmu_circRNA_014961	DOID:114	heart disease	heart failure	"RT-qPCR, microarray"	down-regulated	The distinct expression patterns of circulatory circRNAs during HF indicate that circRNAs may actively respond to stress and thus serve as biomarkers of HF diagnosis and treatment.	1
Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma.	-	hsa_circ_MYLK	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"LncRNA-H19 and circular MYLK as well as circular CTDP1 could regulate the expression of DNMT3B, HAS3, VEGFA and ITGB1 through competing miRNA response elements (MREs) of miRNA-29a-3p, which would result in growth and metastasis of cancer."	3
Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma.	-	hsa_circ_CTDP1	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"LncRNA-H19 and circular MYLK as well as circular CTDP1 could regulate the expression of DNMT3B, HAS3, VEGFA and ITGB1 through competing miRNA response elements (MREs) of miRNA-29a-3p, which would result in growth and metastasis of cancer."	1
The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	up-regulated	"Knockdown of Cdr1as suppressed the expression of miR-7 and also inhibited the CCNE1 and PIK3CD expression. Furthermore, knockdown of Cdr1as suppressed the HCC cell proliferation and invasion through targeting miR-7."	4
hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder.	hsa_circ_0001410	hsa_circ_DCUN1D4	hsa_circRNA_103636	DOID:1470	major depressive disorder	major depressive disorder	"RT-qPCR, microarray"	down-regulated	These results suggest that altered expression of hsa_circRNA_103636 in peripheral blood mononuclear cells (PBMCs) is a potential novel biomarker for the diagnosis and treatment of major depressive disorder (MDD).	1
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0089974	hsa_circ_NHS	circRNA_104983	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	up-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	1
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0000554	hsa_circ_LIN52	circRNA_001059	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	up-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	1
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0002019	hsa_circ_FOXRED1	circRNA_100984	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	up-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	1
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0014879	hsa_circ_DCAF8	circRNA_100367	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	up-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	1
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0004519	hsa_circ_RFWD3	circRNA_101877	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	down-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	1
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0058058	hsa_circ_ATIC	circRNA_102913	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	down-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	2
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0001336	hsa_circ_EEFSEC	circRNA_000695	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	down-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	1
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0000518	hsa_circ_RPPH1	circRNA_000167	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	down-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	1
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.	hsa_circ_0032832	hsa_circ_STON2	circRNA_101419	DOID:1107	esophageal carcinoma	radioresistant esophageal cancer cells	"RT-qPCR, microarray"	down-regulated	"To validate the microarray profiling expression data, realtime quantitative RT-PCR revealed 4 upregulated and 5 downregulated expressed circRNAs as shown in Fig. 2. Expression levels detected by the two methods were consistent with each other, demonstrating the high reliability of the microarray expression results. Our study revealed a comprehensive expression and functional profile of differentially expressed circRNAs in radioresistant esophageal cancer cells, indicating possible involvement of these dysregulated circRNAs in the development of radiation resistance."	1
Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0038374	hsa_circ_IQCK	-	DOID:4752	multiple system atrophy	multiple system atrophy	RT-qPCR	up-regulated	"Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP1, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts. "	1
Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0054211	hsa_circ_MAP4K3	-	DOID:4752	multiple system atrophy	multiple system atrophy	RT-qPCR	up-regulated	"Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP2, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts."	1
Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0032891	hsa_circ_EFCAB11	-	DOID:4752	multiple system atrophy	multiple system atrophy	RT-qPCR	up-regulated	"Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP3, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts."	1
Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0108308	hsa_circ_DTNA	-	DOID:4752	multiple system atrophy	multiple system atrophy	RT-qPCR	up-regulated	"Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP4, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts."	1
Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0005540	hsa_circ_MCTP1	-	DOID:4752	multiple system atrophy	multiple system atrophy	RT-qPCR	up-regulated	"Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP5, were identified and validated as specifically over-expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts."	1
Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0041103	hsa_circ_TCF25	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"Over-expression of circTCF25 could down-regulate miR-103a-3p and miR-107, increase CDK6 expression, and promote proliferation and migration in vitro and vivo."	1
Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0072088	hsa_circ_ZFR	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR."	3
Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0005273	hsa_circ_PTK2	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR."	4
Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0061265	hsa_circ_BC048201	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR."	2
Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0007158	hsa_circ_FAM169A	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	down-regulated	"Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR."	1
Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0082582	hsa_circ_TRIM24	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	down-regulated	"Total of 469 dysregulated circular transcripts are found in bladder cancer compared with normal tissues, among which 285 were up-regulated and 184 were down-regulated. Six circRNAs were identified to have significant differences by qRT-PCR."	1
RBM20 Regulates Circular RNA Production From the Titin Gene.	-	-	cTtns	DOID:12930	dilated cardiomyopathy	dilated cardiomyopathy	"RT-qPCR, RNA-seq"	down-regulated	"RBM20 is crucial for the formation of a subset of circRNAs that originate from the I-band of the titin gene. RBM20, by excluding specific exons from the pre-mRNA, provides the substrate to form this class of RBM20-dependent circRNAs."	1
RBM20 Regulates Circular RNA Production From the Titin Gene.	-	-	cTtns	DOID:12930	dilated cardiomyopathy	dilated cardiomyopathy	"RT-qPCR, RNA-seq"	down-regulated	We show in a patient with an RBM20 mutation and in Rbm20 knockout mice that RBM20 function is required for the production of circRNAs from the I-band region of titin. This suggests that loss of RBM20 may induce myocardial disease not only by abnormal splicing of linear transcripts but possibly also by loss of a specific class of conserved and regulated circRNAs.	1
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.	-	hsa_circ_ANRIL	-	DOID:1936	atherosclerosis	atherosclerosis	RT-qPCR	up-regulated	"CircANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis."	4
Landscape of RNAs in human lumbar disc degeneration.	hsa_circ_0040039	hsa_circ_SNTB2	-	DOID:90	degenerative disc disease	intervertebral disc degeneration	"RT-qPCR, microarray"	up-regulated	"To validate the circRNAs microarray result, two circRNAs were selected for qRT-PCR validation. The expression of has-circRNA-101852 (P < 0.05) was significantly increased in degenerative samples compared with control whereas the expression of has-circRNA-101645 (P < 0.05) was significantly decreased."	1
Landscape of RNAs in human lumbar disc degeneration.	hsa_circ_0036763	hsa_circ_SEMA4B	-	DOID:90	degenerative disc disease	intervertebral disc degeneration	"RT-qPCR, microarray"	down-regulated	"To validate the circRNAs microarray result, two circRNAs were selected for qRT-PCR validation. The expression of has-circRNA-101852 (P < 0.05) was significantly increased in degenerative samples compared with control whereas the expression of has-circRNA-101645 (P < 0.05) was significantly decreased."	2
"A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis."	-	mmu_circ_Rar1	-	DOID:3602	toxic encephalopathy	lead-induced neuronal cell apoptosis	RNA-seq	up-regulated	lncRpa and circRar1 induced the upregulation of apoptosis-associated factors caspase8 and p38 at the mRNA and protein levels via modulation of their common target microRNA miR-671. 	1
Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia.	-	-	hsa_circRNA_100782	DOID:10591	pre-eclampsia	preeclampsia	"RT-qPCR, microarray"	up-regulated	"The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls."	1
Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia.	-	-	hsa_circRNA_102682	DOID:10591	pre-eclampsia	preeclampsia	"RT-qPCR, microarray"	up-regulated	"The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls."	1
Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia.	-	-	hsa_circRNA_104820	DOID:10591	pre-eclampsia	preeclampsia	"RT-qPCR, microarray"	up-regulated	"The expression levels of hsa_circRNA_100782 (p < 0.05), hsa_circRNA_102682 (p < 0.05), and hsa_circRNA_104820 (p < 0.0001) were validated as significantly up-regulated in the experimental group compared with the controls."	1
Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction.	-	-	MICRA	DOID:5844	myocardial infarction	myocardial Infarction	RT-qPCR	down-regulated	"we identified a circRNA, MICRA, whose expression levels measured at reperfusion in peripheral blood samples of patients with acute MI predicted LV dysfunction after 3 to 4 months."	2
Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/beta-catenin signaling pathway.	-	hsa_circ_ZNF292	cZNF292	DOID:0060108	brain glioma	glioma	RT-qPCR	down-regulated	cZNF292 silencing suppresses tube formation by inhibiting glioma cell proliferation and cell cycle progression.	1
The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	down-regulated	"The expression levels of ciRS-7 were comparable between HCC and matched non-tumor tissues. However, the highly ciRS-7 expression in HCC tissues was significantly correlated with hepatic MVI, AFP level and younger age and thus partly related with the deterioration of HCC. Especially, ciRS-7 was one of the independent factors of hepatic MVI."	4
Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/beta-Catenin Pathway.	-	hsa_circ_ITCH	"cir-ITCH, circ-ITCH"	DOID:1324	lung cancer	lung cancer	RT-qPCR	down-regulated	"cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/beta-catenin signaling. cir-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression."	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_013935	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	up-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_002319	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	up-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_016983	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	up-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_009295	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	up-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_017649	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	up-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_011775	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	down-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_011174	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	down-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_006982	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	down-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_010484	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	down-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.	-	-	mm9_circ_011235	DOID:80547	non-alcoholic steatohepatitis	nonalcoholic steatohepatitis	"RT-qPCR, microarray"	down-regulated	CircRNA profile may serve as candidate for NASH diagnosis and circRNA-miRNA -mRNA pathway may provide novel mechanism for NASH.	1
The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression.	-	mmu_circ_FOXO3	-	DOID:114	heart disease	cardiac fibrosis	RT-qPCR	up-regulated	"In this study, mice injected with the chemotherapeutic agent Doxorubicin (Dox) for induction of cardiomyopathy were analyzed for RNA expression levels. Mice with reduced cardiac function had increased expression of circ-Foxo3."	2
Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation.	hsa_circ_0067934	hsa_circ_PRKCI	-	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	RT-qPCR	up-regulated	The in vitro silence of hsa_circ_0067934 by siRNA inhibited the proliferation and migration of esophageal squamous cell carcinoma (ESCC) cells and blocked cell cycle progression.	2
Circular RNAs and their associations with breast cancer subtypes.	-	-	MCF7_circ_000595	DOID:1612	breast cancer	breast cancer	RNA-seq	up-regulated	"This circRNA was found at chr14:102,466,325_102,500,789 and had 12 supporting junction-spanning reads. This circRNA was a spliced product of gene DYNC1H1 and spanned from exons 17 to 56 of the gene. Considering that the exon-intron structure remains intact, the size of this circRNA is about 7 kb and may play a role in post-transcriptional regulation. Notably, the circRNA contained microRNA response elements (MRE) for miR-150 and miR-661 with 29 and 23 unique binding sites respectively. These two microRNAs have been previously reported to have associations with cancer."	1
Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus.	hsa_circ_0054633	hsa_circ_PNPT1	-	DOID:9352	type 2 diabetes mellitus	type 2 diabetes mellitus	"RT-qPCR, microarray"	up-regulated	Hsa_circ_0054633 presented a certain diagnostic capability for pre-diabetes and T2DM.	3
Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity.	-	hsa_circ_FOXO3	-	DOID:1612	breast cancer	breast cancer	RT-qPCR	down-regulated	"silencing endogenous circ-Foxo3 enhanced cell viability, whereas ectopic expression of circ-Foxo3 triggered stress-induced apoptosis and inhibited the growth of tumor xenografts."	3
Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.	-	hsa_circ_FAT1	-	DOID:219	colon cancer	colon cancer	"RT-qPCR, RNA-seq"	down-regulated	CircFAT1 was significantly down-regulated in the mutant_RAS_ell line (HCT116).	1
Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.	-	hsa_circ_ARHGAP5	-	DOID:219	colon cancer	colon cancer	"RT-qPCR, RNA-seq"	down-regulated	two of three significantly regulated circRNAs between_RAS_utant and WT exosomes were down-regulated in_RAS_utant (circFAT1 and circARHGAP5).	1
Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung disease.	hsa_circ_0000615	hsa_circ_ZNF609	-	DOID:10487	Hirschsprung disease	hirschsprung disease	RT-qPCR	down-regulated	Cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.	1
Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.	-	hsa_circ_PVT1	-	DOID:1324	lung cancer	lung cancer	"RT-qPCR, RNA-seq"	up-regulated	"Our findings indicate that the SAC-RNA CircPVT1, elevated in dividing cells and reduced in senescent cells, sequesters let-7 to enable a proliferative phenotype."	3
Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.	-	hsa_circ_PVT1	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, RNA-seq"	up-regulated	"Our findings indicate that the SAC-RNA CircPVT1, elevated in dividing cells and reduced in senescent cells, sequesters let-7 to enable a proliferative phenotype."	4
Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer.	-	hsa_circ_PVT1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, RNA-seq"	up-regulated	CircPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC.	6
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	"RT-qPCR, microarray"	up-regulated	"To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data."	1
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray.	hsa_circ_0005397	hsa_circ_RHOT1	-	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	"RT-qPCR, microarray"	up-regulated	"To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data."	1
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray.	hsa_circ_0006913	hsa_circ_ARID1A	-	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	"RT-qPCR, microarray"	down-regulated	"To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data."	1
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray.	hsa_circ_0000257	hsa_circ_NOLC1	-	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	"RT-qPCR, microarray"	down-regulated	"To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data."	1
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray.	hsa_circ_0005785	hsa_circ_ANAPC7	-	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	"RT-qPCR, microarray"	down-regulated	"To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data."	1
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray.	hsa_circ_0041150	hsa_circ_RPH3AL	-	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	"RT-qPCR, microarray"	down-regulated	"To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data."	1
Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray.	hsa_circ_0008719	hsa_circ_AKT2	-	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	"RT-qPCR, microarray"	down-regulated	"To verify the microarray data, we randomly selected seven differentially expressed circRNAs, including two up-regulated circRNAs and five down-regulated circRNAs (including hsa_circ_0001946, hsa_circ_0005397, hsa_circ_0006913, hsa_circ_0000257, hsa_circ_0005785, hsa_circ_0041150, and hsa_circ_0008719). We validated their expression levels via qRT-PCR in 20 sets of PDAC tissues and adjacent normal tissues. We found that the expression patterns of seven circRNAs were consistent with the microarray data."	1
"Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer."	hsa_circ_0000069	hsa_circ_STIL	-	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	up-regulated	"By using specically designed siRNAs in colorectal cancer (CRC) cells, a functional analysis was performed which revealed that hsa_circ_0000069 knockdown could notably inhibit cell prolif- eration, migration, and invasion, and induce G0/G1 phase arrest of cell cycle in vitro."	4
Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease.	hsa_circ_0124644	hsa_circ_ROBO2	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	Hsa_circ_0124644 can be used as a diagnostic biomarker of CAD.	2
Parasite biology: Busting out from the inside.	hsa_circ_0082081	hsa_circ_CADPS2	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	"Hsa_circ_0082081 and hsa_circ_0124644 were moderately correlated with the CADS, hsa_circ_0113854 and hsa-circRNA5974-1 were weakly correlated with the CADS and hsa_circ_0098964 was not correlated with the CADS."	1
Viral infection: Fine tuning HCV replication.	hsa_circ_0113854	hsa_circ_ATG4C	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	"Hsa_circ_0082081 and hsa_circ_0124644 were moderately correlated with the CADS, hsa_circ_0113854 and hsa-circRNA5974-1 were weakly correlated with the CADS and hsa_circ_0098964 was not correlated with the CADS."	1
Bacterial physiology: Building a bacterial ribosome.	hsa_circ_0098964	hsa_circ_SRGAP1	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	"Hsa_circ_0082081 and hsa_circ_0124644 were moderately correlated with the CADS, hsa_circ_0113854 and hsa-circRNA5974-1 were weakly correlated with the CADS and hsa_circ_0098964 was not correlated with the CADS."	1
Bacterial physiology: Building a bacterial ribosome.	-	-	hsa-circRNA5974-1	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	"Hsa_circ_0082081 and hsa_circ_0124644 were moderately correlated with the CADS, hsa_circ_0113854 and hsa-circRNA5974-1 were weakly correlated with the CADS and hsa_circ_0098964 was not correlated with the CADS."	1
"Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis."	-	-	hsa_circRNA_100284	DOID:4159	skin cancer	skin cancer	microarray	up-regulated	"Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis. This establishes a previously unknown mechanism between arsenite-induced acceleration of the cell cycle and carcinogenesis."	1
"CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts."	-	-	circRNA_000203	DOID:114	heart disease	cardiac fibrosis	"RT-qPCR, microarray"	up-regulated	"Enforced-expression of circRNA_000203 could increase expressions of Col1a2, Col3a1 and ?Âą-SMA in mouse cardiac fibroblasts. over-expression of circRNA_000203 could eliminate the anti-fibrosis effect of miR-26b-5p in cardiac fibroblasts."	2
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.	hsa_circ_0031288	hsa_circ_PABPN1	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN1 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels."	2
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.	hsa_circ_0002343	hsa_circ_B3GALNT2	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN2 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels."	1
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.	hsa_circ_0069399	hsa_circ_ARAP2	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN3 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels."	1
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.	hsa_circ_0007386	hsa_circ_CRIM1	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN4 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels."	1
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.	hsa_circ_0008844	hsa_circ_MFSD2A	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN5 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels."	1
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.	hsa_circ_0001212	hsa_circ_GUSBP11	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN6 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels."	1
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.	hsa_circ_0001187	hsa_circ_DOPEY2	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN7 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels."	1
Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.	hsa_circ_0007928	hsa_circ_DCUN1D4	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"In summary, HuR binds numerous circRNAs in HeLa cells. The circRNA showing the most abundant association with HuR,_ircPABPN1, suppressed HuR binding to_ABPN1_RNA without influencing HuR levels or_ABPN1_RNA levels. Interestingly, by preventing HuR binding to_ABPN1_RNA,_ircPABPN1_uppressed PABPN8 translation and lowered cell proliferation. We propose that other circRNAs might affect selectively the expression of certain mRNAs at similar post-transcriptional levels."	1
Circular RNA 0000096 affects cell growth and migration in gastric cancer.	hsa_circ_0000096	hsa_circ_HIAT1	-	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	"Hsa_circ_0000096 may be used as a potential novel biomarker for gastric cancer. It affects gastric cancer cell growth and migration by regulating cyclin D1, CDK6, MMP-2 and MMP-9."	3
A landscape of circular RNA expression in the human heart.	-	hsa_circ_SLC8A1-1	CircSLC8A1-1	DOID:114	heart disease	heart disease	"RT-qPCR, RNA-seq"	up-regulated	"Flanking introns of the most abundantly expressed circRNA, circSLC8A1-1, are unusually long (250_618_nt) and are enriched with Alu elements."	1
A landscape of circular RNA expression in the human heart.	-	mmu_circ_SLC8A1-1	CircSLC8A1-1	DOID:114	heart disease	heart disease	"RT-qPCR, RNA-seq"	up-regulated	"Using single molecule RNA-FISH,  the cytoplasmic localization of circSlc8a1-1 was established in adult mouse cardiomyocytes."	1
Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals.	-	hsa_circ_HIAT1	-	DOID:4467	clear cell renal cell carcinoma	clear cell renal cell carcinoma	RT-qPCR	down-regulated	"The consequences of AR-suppressed circHIAT1 resulted in deregulating miR-195-5p/29a-3p/29c-3p expression, which increased CDC42 expression to enhance ccRCC cell migration and invasion. Increasing this newly identified signal via circHIAT1 suppressed ARenhanced ccRCC cell migration and invasion. Together, these results suggested that circHIAT1 functioned as a metastatic inhibitor to suppress AR-enhanced ccRCC cell migration and invasion."	1
"Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer."	-	hsa_circ_BANP	-	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, microarray"	up-regulated	Knockdown of circ-BANP with siRNA significantly attenuate the proliferation of CRC cells.	3
Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer.	hsa_circ_0000190	hsa_circ_CNIH4	-	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	Hsa_circ_0000190 may be a novel non-invasive biomarker for the diagnosis of gastric cancer.	3
Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance.	hsa_circ_0001649	hsa_circ_SHPRH	-	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	Our test suggested that hsa_circ_0001649 was significantly downregulated in GC and may become a novel potential biomarker in the diagnosis of GC.	2
Circular RNA ciRS-7-A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	up-regulated	"Functional assays identified overexpression of ciRS-7 in HCT116 and HT29 cells led to blocking of tumor suppressive effects of miR-7 and resulted in a more aggressive oncogenic phenotype, which was subsequently validated in cell lines and a xenograft animal model."	2
Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.	-	-	hsa_circRNA_400071	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. "	1
Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.	-	-	hsa_circRNA_000543	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. "	1
Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.	-	-	hsa_circRNA_001959	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. "	1
Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.	-	-	hsa_circRNA_000792	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. "	1
Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.	-	-	hsa_circRNA_400066	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. "	1
Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.	-	-	hsa_circRNA_001066	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"We randomly verified three circRNAs (hsa_circRNA_400071, hsa_circRNA_000792 and hsa_circRNA_000543) with upregulated expression and three circRNAs (hsa_circRNA_001959, hsa_circRNA_400066 and hsa_circRNA_001066) with downregulated expression. There were significant differences in all of the selected circRNAs (P<0.05) with the exception of hsa_circRNA_000543. Differentially expressed circRNAs had corresponding miRNA binding sites. These circRNAs regulated the expression of target genes through interactions with miRNAs and might become new molecular biomarkers for gastric cancer (GC) in the future. "	1
Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.	-	-	hsa_circRNA_101308	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery.	1
Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.	-	-	hsa_circRNA_104423	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery.	1
Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.	-	-	hsa_circRNA_104916	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery.	1
Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.	-	-	hsa_circRNA_100269	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	Our study suggested that this four-circRNA-based classifier yielded a predictive ability to the early recurrence of stage III gastric cancer after radical surgery.	2
Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.	-	-	hsa_circRNA_400033	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort.	1
Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.	-	-	hsa_circRNA_001653	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort.	1
Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.	-	-	hsa_circRNA_103781	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort.	1
Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.	-	-	hsa_circRNA_103999	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	We further screened eight indicators related to early recurrence. We subsequently divided the remaining cases into two cohorts. qRT-PCR results demonstrated a significantly different outcome between low and high expressed groups of four circRNAs in the training cohort.	1
"ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways."	hsa_circ_0001727	hsa_circ_ZKSCAN1	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RNA-seq	down-regulated	"ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration."	3
TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1beta/Derlin-1 pathway.	hsa_circ_0000594	hsa_circ_TTBK2	-	DOID:0060108	brain glioma	glioma	RT-qPCR	up-regulated	"Enhanced expression of circ-TTBK2 promoted cell proliferation, migration, and invasion, while inhibited apoptosis."	4
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0006460	hsa_circ_BRAF	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0005603	hsa_circ_MAP2K4	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0008345	hsa_circ_PTK2	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	2
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0004872	hsa_circ_MAPK1	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0006411	hsa_circ_PIK3R1	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0003586	hsa_circ_NF1	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	2
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0002968	hsa_circ_MAPK8	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0000199	hsa_circ_AKT3	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	2
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	-	-	chr4:103501692-103504114	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	hsa_circ_0001566	hsa_circ_MAPK9	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	down-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	-	-	chr18:107887-108499	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	up-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.	-	-	chr19:5761476-5761630	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, RNA-seq"	up-regulated	"The present study identified a profile of dysregulated circRNAs in GBM. Bioinformatics analysis showed that dysregulated circRNAs might be associated with tumorigenesis and development of GBM. In addition, circBRAF could severe as a biomarker for predicting pathological grade and prognosis in glioma patients."	1
Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis.	-	hsa_circ_CCDC66	-	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, RNA-seq"	up-regulated	"Gain-of-function and loss-of-function studies in CRC cell-lines demonstrated that circCCDC66 controlled multiple pathological processes, including cell proliferation, migration, invasion, and anchorage-independent growth."	4
The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis.	hsa_circ_0106803	hsa_circ_GSDMB	GSDMB ecircRNA	DOID:2377	multiple sclerosis	multiple sclerosis	RT-qPCR	up-regulated	"Both alternative splicing (AS) isoforms and the identified ecircRNA were significantly dysregulated in peripheral blood mononuclear cells of relapsing-remitting multiple sclerosis (MS) patients compared to controls, further supporting the notion that aberrant RNA metabolism is a characteristic feature of the disease."	1
CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a.	hsa_circ_0005105	hsa_circ_SEC24A	-	DOID:8398	osteoarthritis	osteoarthritis	RT-qPCR	up-regulated	Hsa_circ_0005105 can promote extracellular matrix (ECM) degradation by regulating the expression of miR-26a target NAMPT.	3
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0004277	hsa_circ_WDR37	-	DOID:1240	leukemia	leukemia	"RT-qPCR, microarray"	down-regulated	"A downregulated circRNA, hsa_circ_0004277, was characterized and functionally evaluated in a cohort of 115 human samples, thus offering a potential diagnostic marker and treatment target in acute myeloid leukemia (AML)."	1
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0035381	hsa_circ_PIGB	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	"RT-qPCR, microarray"	up-regulated	"Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression. qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile."	2
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0004136	hsa_circ_KCNQ5	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	"RT-qPCR, microarray"	up-regulated	"Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression. qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile."	2
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0058058	hsa_circ_ATIC	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	"RT-qPCR, microarray"	up-regulated	"Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression. qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile."	1
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0017446	hsa_circ_WDR37	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	"RT-qPCR, microarray"	down-regulated	"Five abundant circRNAs (hsa_circ_0035381, hsa_circ_0004136, hsa_circ_0058058, hsa_circ_0017446, hsa_circ_0004277) were chosen based on the significant difference and raw signal intensity of expression. qRT-PCR results were consistent with the microarray results, as three circRNAs were upregulated and two were downregulated in AML patients, thus demonstrating high reliability of this circRNA profile."	1
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0049657	hsa_circ_NFIX	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	microarray	up-regulated	"Two upregulated circRNAs (hsa_circ_0035381, hsa_circ_0049657) and three downregulated circRNAs (hsa_circ_0001187, hsa_circ_0008078, hsa_circ_0001947) were found within the whole profile. This result showed us a circRNA signature not only presents in AML, but also potentially contributes to AML risk-status evaluation."	2
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0001187	hsa_circ_DOPEY2	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	microarray	down-regulated	"Two upregulated circRNAs (hsa_circ_0035381, hsa_circ_0049657) and three downregulated circRNAs (hsa_circ_0001187, hsa_circ_0008078, hsa_circ_0001947) were found within the whole profile. This result showed us a circRNA signature not only presents in AML, but also potentially contributes to AML risk-status evaluation."	3
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0008078	hsa_circ_DOPEY2	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	microarray	down-regulated	"Two upregulated circRNAs (hsa_circ_0035381, hsa_circ_0049657) and three downregulated circRNAs (hsa_circ_0001187, hsa_circ_0008078, hsa_circ_0001947) were found within the whole profile. This result showed us a circRNA signature not only presents in AML, but also potentially contributes to AML risk-status evaluation."	3
Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0001947	hsa_circ_AFF2	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	microarray	down-regulated	"Two upregulated circRNAs (hsa_circ_0035381, hsa_circ_0049657) and three downregulated circRNAs (hsa_circ_0001187, hsa_circ_0008078, hsa_circ_0001947) were found within the whole profile. This result showed us a circRNA signature not only presents in AML, but also potentially contributes to AML risk-status evaluation."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0015278	hsa_circ_KLHL20	hsa_circRNA_100395	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	down-regulated	"CircRNA dysregulation may play a role in papillary thyroid carcinoma (PTC) pathogenesis, and several key circRNAs show promise as candidate biomarkers for PTC. The hsa_circRNA_100395/miR-141-3p/ miR-200a-3p axis may be involved in the pathogenesis of PTC."	2
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0021553	hsa_circ_MPPED2	hsa_circRNA_100777	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	down-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0079891	hsa_circ_ELMO1	hsa_circRNA_104348	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	down-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0067103	hsa_circ_ZNF148	hsa_circRNA_103454	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	down-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0004458	hsa_circ_PSD3	hsa_circRNA_104566	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	5
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0002111	hsa_circ_PSD3	hsa_circRNA_104565	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	5
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0008016	hsa_circ_FGFR1	hsa_circRNA_104595	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0004771	hsa_circ_NRIP1	hsa_circRNA_103110	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	2
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0091894	hsa_circ_FLNA	hsa_circRNA_105038	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0092315	hsa_circ_PWP2	hsa_circRNA_400064	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0078738	hsa_circ_WDR27	hsa_circRNA_104268	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	2
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0064557	hsa_circ_SATB1	hsa_circRNA_103307	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0000516	hsa_circ_RPPH1	hsa_circRNA_001379	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0004846	hsa_circ_SAMD4A	hsa_circRNA_101356	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0003505	hsa_circ_USP22	hsa_circRNA_102002	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0081342	hsa_circ_ARPC1B	hsa_circRNA_104433	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	"RT-qPCR, microarray"	up-regulated	"The 12 significantly upregulated circRNAs (Fig 5A, Table 2) as well as the four significantly downregulated circRNAs (Fig 5A, Table 3) were selected for qRT-PCR validation. The qRT-PCR results revealed that all 12 upregulated circRNAs and all four downregulated circRNAs were significantly differentiated between PTC tumors versus matching normal thyroid tissue."	1
The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-kappaB-dependent manner.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:10652	Alzheimer disease	Alzheimer disease	RT-qPCR	down-regulated	"ciRS-7 expression inhibits translation of NF-kappaB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation."	1
Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value.	hsa_circ_0023404	hsa_circ_RNF121	circRNA_100876	DOID:3908	lung non-small cell carcinoma	non-small cell lung cancer	RT-qPCR	up-regulated	CircRNA 100876 is closely related to the carcinogenesis of NSCLC and it might be served as a potential prognostic biomarker and therapeutic target for NSCLC.	2
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.	-	hsa_circ_ZNF609	-	DOID:11723	duchenne muscular dystrophy	duchenne muscular dystrophy	"RT-qPCR, RNA-seq"	up-regulated	"Circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, providing an example of a protein-coding circRNA in eukaryotes."	1
Identification of differentially expressed circular RNAs in human colorectal cancer.	-	hsa_circ_ZFR	hsa_circRNA_103809	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, microarray"	down-regulated	The expression levels of hsa_circRNA_103809 and hsa_circRNA_104700 were significantly downregulated in 170 CRC tissues and they were associated with tumor progression.	2
Identification of differentially expressed circular RNAs in human colorectal cancer.	-	hsa_circ_PTK2	hsa_circRNA_104700	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, microarray"	down-regulated	The expression levels of hsa_circRNA_103809 and hsa_circRNA_104700 were significantly downregulated in 170 CRC tissues and they were associated with tumor progression.	4
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family.	hsa_circ_0013339	hsa_circ_SLC30A7	circRNA_100290	DOID:50866	oral squamous cell carcinoma	oral squamous cell carcinoma	"RT-qPCR, microarray"	up-regulated	CircRNA_100290 was upregulated and co-expressed with CDK6 in oral squamous cell carcinomas (OSCC) tissue. Knockdown of circRNA_100290 decreased expression of CDK6 and inhibited proliferation of OSCC cell lines in vitro and in vivo.	1
Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma.	hsa_circ_0005986	hsa_circ_PRDM2	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	down-regulated	Hsa_circ_0005986 downregulation liberated miR-129-5p and decreased the expression level of Notch1mRNA. hsa_circ_0005986 downregulation accelerated cell proliferation by promoting the G0/G1 to S phase transition.	2
"A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-beta1."	-	-	circRNA_010567	DOID:114	heart disease	diabetic myocardial fibrosis	"RT-qPCR, microarray"	up-regulated	CircRNA_010567/miR-141/TGF-beta1 axis plays an important regulatory role in the diabetic mice myocardial fibrosis model.	1
Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.	-	gga_circ_RAB6A	chr1:194735582-194744050	DOID:934	viral infectious disease	avian leukosis virus subgroup	"RT-qPCR, RNA-seq"	up-regulated	Two randomly selected circRNAs that were upregulated in ALV-J-resistant chickens (chr1:194735582-194744050- and chr23:5549365-5549645-) and two randomly circRNAs that were downregulated in ALVJ-resistant chickens (chr8:1033880-1047222- and chr5:58225735-58230830-) were selected to validate the expression levels of the significantly differentially expressed circRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). The qRT-PCR data for the four circRNAs was consistent with the trends observed using circRNA sequencing.	1
Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.	-	gga_circ_HMGCL	chr23:5549365-5549645	DOID:934	viral infectious disease	avian leukosis virus subgroup	"RT-qPCR, RNA-seq"	up-regulated	Two randomly selected circRNAs that were upregulated in ALV-J-resistant chickens (chr1:194735582-194744050- and chr23:5549365-5549645-) and two randomly circRNAs that were downregulated in ALVJ-resistant chickens (chr8:1033880-1047222- and chr5:58225735-58230830-) were selected to validate the expression levels of the significantly differentially expressed circRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). The qRT-PCR data for the four circRNAs was consistent with the trends observed using circRNA sequencing.	1
Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.	-	-	chr8:1033880-1047222	DOID:934	viral infectious disease	avian leukosis virus subgroup	"RT-qPCR, RNA-seq"	down-regulated	Two randomly selected circRNAs that were upregulated in ALV-J-resistant chickens (chr1:194735582-194744050- and chr23:5549365-5549645-) and two randomly circRNAs that were downregulated in ALVJ-resistant chickens (chr8:1033880-1047222- and chr5:58225735-58230830-) were selected to validate the expression levels of the significantly differentially expressed circRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). The qRT-PCR data for the four circRNAs was consistent with the trends observed using circRNA sequencing.	1
Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.	-	-	chr5:58225735-58230830	DOID:934	viral infectious disease	avian leukosis virus subgroup	"RT-qPCR, RNA-seq"	down-regulated	Two randomly selected circRNAs that were upregulated in ALV-J-resistant chickens (chr1:194735582-194744050- and chr23:5549365-5549645-) and two randomly circRNAs that were downregulated in ALVJ-resistant chickens (chr8:1033880-1047222- and chr5:58225735-58230830-) were selected to validate the expression levels of the significantly differentially expressed circRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). The qRT-PCR data for the four circRNAs was consistent with the trends observed using circRNA sequencing.	1
Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis.	-	-	rno_circ_0006928	DOID:936	brain disease	neuropathic pain	"RT-qPCR, RNA-seq"	up-regulated	"Our data showed that the most significantly involved pathways in SNI pathogenesis were ribosome, PI3K-Akt signaling pathway, focal adhesion, ECM-receptor interaction, amoebiasis and protein digestion and absorption. In addition, the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA network of NP was constructed. This is the first study to comprehensively identify regulated ncRNAs of the spinal cord and to demonstrate the involvement of different ncRNA expression patterns in the spinal cord of NP pathogenesis by sequence analysis. "	1
Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis.	-	-	rno circ 0004058	DOID:936	brain disease	neuropathic pain	"RT-qPCR, RNA-seq"	up-regulated	"Our data showed that the most significantly involved pathways in SNI pathogenesis were ribosome, PI4K-Akt signaling pathway, focal adhesion, ECM-receptor interaction, amoebiasis and protein digestion and absorption. In addition, the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA network of NP was constructed. This is the first study to comprehensively identify regulated ncRNAs of the spinal cord and to demonstrate the involvement of different ncRNA expression patterns in the spinal cord of NP pathogenesis by sequence analysis."	1
Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis.	-	-	rno circ 0005854	DOID:936	brain disease	neuropathic pain	"RT-qPCR, RNA-seq"	down-regulated	"Our data showed that the most significantly involved pathways in SNI pathogenesis were ribosome, PI5K-Akt signaling pathway, focal adhesion, ECM-receptor interaction, amoebiasis and protein digestion and absorption. In addition, the lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA network of NP was constructed. This is the first study to comprehensively identify regulated ncRNAs of the spinal cord and to demonstrate the involvement of different ncRNA expression patterns in the spinal cord of NP pathogenesis by sequence analysis."	1
"Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells."	hsa_circ_0016347	hsa_circ_KCNH1	-	DOID:3347	osteosarcoma	osteosarcoma	RT-qPCR	up-regulated	We demonstrated that circ-0016347 acted as a positive regulator in osteosarcoma cells proliferation and invasion.	2
Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	up-regulated	"CDR1as had a higher expression in CRC tissues compared to adjacent, normal mucosa and was positively associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS). Downregulation of CDR1as suppressed CRC cell proliferation and invasion and increased microRNA-7 (miR-7) expression. Intriguingly, ectopic expression of miR-7 in CRC cells consistently inhibited proliferation and invasion, and the miR-7 inhibitor was able to rescue the function of CDR1as knockdown. "	2
Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances.	hsa_circ_0001895	hsa_circ_PRRC2B	hsa_circ_000760	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	Hsa_circ_0001895 may play crucial roles during gastric cancerogenesis and is a potential biomarker for clinical prognosis prediction.	2
Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0004771	hsa_circ_NRIP1	hsa_circ_103110	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements."	2
Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0001824	hsa_circ_ASAP1	hsa_circ_104689	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements."	1
Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0001875	hsa_circ_FAM120A	hsa_circ_104821	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements."	1
Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0006054	hsa_circ_KIAA0355	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	down-regulated	"The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements."	1
Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0004619	hsa_circ_FAF1	hsa_circ_100219	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	down-regulated	"The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements."	2
Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	-	-	hsa_circ_406697	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	down-regulated	"The validation study demonstrated that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 levels were elevated in breast cancer tissues, whereas hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated. These circRNAs targeted complementary miRNA response elements."	1
Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance.	hsa_circ_0003570	hsa_circ_FAM53B	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, microarray"	down-regulated	Hsa_circ_0003570 was closely correlated with the clinicopathological characteristics of patients with HCC and the background of cirrhosis was related to the decreased hsa_circ_0003570 in HCC patients.	3
Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression.	-	mmu_circ_Smyd4	mm9_circ_016597	DOID:1287	cardiovascular system disease	cardiovascular disease	RT-qPCR	down-regulated	"A circRNA (mitochondrial fission and apoptosis-related circRNA, termed as MFACR) regulates mitochondrial fission and apoptosis in the heart by directly targeting and downregulating miR-652-3p; this in turn blocks mitochondrial fission and cardiomyocyte cell death by suppressing MTP18 translation. Our results reveal a crucial role for circRNA in regulating mitochondrial dynamics and apoptosis in the heart; as such, circRNAs may serve as a potential therapeutic avenue for cardiovascular diseases."	1
Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0058106	hsa_circ_FN1	-	DOID:8533	hypopharynx cancer	hypopharyngeal cancer	"RT-qPCR, microarray"	up-regulated	"The expression levels of hsa_circ_0058106, hsa_circ_0058107, and hsa_circ_0024108 were significantly higher in tumor tissues than in corresponding normal tissues. These data were consistent with the results of the microarray data, indicating the reliability of these results."	2
Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0058107	hsa_circ_FN1	-	DOID:8533	hypopharynx cancer	hypopharyngeal cancer	"RT-qPCR, microarray"	up-regulated	"The expression levels of hsa_circ_0058106, hsa_circ_0058107, and hsa_circ_0024108 were significantly higher in tumor tissues than in corresponding normal tissues. These data were consistent with the results of the microarray data, indicating the reliability of these results."	2
Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0024108	hsa_circ_MMP1	-	DOID:8533	hypopharynx cancer	hypopharyngeal cancer	"RT-qPCR, microarray"	up-regulated	"The expression levels of hsa_circ_0058106, hsa_circ_0058107, and hsa_circ_0024108 were significantly higher in tumor tissues than in corresponding normal tissues. These data were consistent with the results of the microarray data, indicating the reliability of these results."	1
Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0036722	hsa_circ_RHCG	-	DOID:8533	hypopharynx cancer	hypopharyngeal cancer	"RT-qPCR, microarray"	down-regulated	"Hsa_circ_0036722, hsa_circ_0002260, and hsa_circ_0001189 expression levels were significantly decreased in tumor tissues compared with normal controls. These data were consistent with the results of the microarray data, indicating the reliability of these results."	1
Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0002260	hsa_circ_PAPD4	-	DOID:8533	hypopharynx cancer	hypopharyngeal cancer	"RT-qPCR, microarray"	down-regulated	"Hsa_circ_0036722, hsa_circ_0002260, and hsa_circ_0001189 expression levels were significantly decreased in tumor tissues compared with normal controls. These data were consistent with the results of the microarray data, indicating the reliability of these results."	1
Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0001189	hsa_circ_MORC3	-	DOID:8533	hypopharynx cancer	hypopharyngeal cancer	"RT-qPCR, microarray"	down-regulated	"Hsa_circ_0036722, hsa_circ_0002260, and hsa_circ_0001189 expression levels were significantly decreased in tumor tissues compared with normal controls. These data were consistent with the results of the microarray data, indicating the reliability of these results."	2
Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.	hsa_circ_0007874	hsa_circ_MTO1	hsa_circ_104135	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	down-regulated	"CircMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR-9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment. The decrease of circMTO1 in HCC tissues may serve as a prognosis predictor for poor survival of patients."	3
Profiling and bioinformatics analyses reveal differential circular RNA expression in hypertensive patients.	hsa_circ_0005870	hsa_circ_SETD2	-	DOID:10763	hypertension	hypertension	"RT-qPCR, microarray"	down-regulated	Gene oncology and KEGG pathway analysis enriched from specific mRNAs indicated the involvement of hsa-circ-0005870 in hypertension.	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0014717	hsa_circ_CCT3	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	Hsa_circ_0014717 stably exists in human gastric juice and significantly decreased in chronic atrophic gastritis group.	2
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0035445	hsa_circ_ALDH1A2	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0003789	hsa_circ_TSN	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0063809	hsa_circ_CELSR1	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0074362	hsa_circ_ARHGAP26	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	3
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0006282	hsa_circ_TCEB1	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	3
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0011107	hsa_circ_RPA2	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0084606	hsa_circ_ASPH	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0005556	hsa_circ_NBAS	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	3
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0050547	hsa_circ_UBA2	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0006470	hsa_circ_MFN2	-	DOID:10534	stomach cancer	gastric cancer	microarray	up-regulated	"The top 10 upregulated (hsa_circ_0035445, hsa_circ_0003789, hsa_circ_0063809, hsa_circ_0074362, hsa_circ_0006282, hsa_circ_0011107, hsa_circ_0084606, hsa_circ_0005556, hsa_circ_0050547, and hsa_circ_0006470) circRNAs in gastric cancer tissues are listed in Table 1."	5
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0007099	hsa_circ_ABHD2	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	2
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0001897	hsa_circ_POMT1	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	2
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0007707	hsa_circ_LCOR	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	2
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0008832	hsa_circ_FBXO7	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0001546	hsa_circ_FAM114A2	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	2
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0002089	hsa_circ_ARHGEF12	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0004680	hsa_circ_CCT3	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	2
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0000154	hsa_circ_DCAF6	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	2
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0004458	hsa_circ_PSD3	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	1
Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0008394	hsa_circ_TIMMDC1	-	DOID:10534	stomach cancer	gastric cancer	microarray	down-regulated	"The top 10 downregulated (hsa_circ_0007099, hsa_circ_0001897, hsa_circ_0007707, hsa_circ_0008832, hsa_circ_0001546, hsa_circ_0002089, hsa_circ_0004680, hsa_circ_0000154, hsa_circ_0004458, and hsa_circ_0008394) circRNAs in gastric cancer tissues are listed in Table 1."	1
Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	up-regulated	"Overexpression of ciRS-7 blocked the miR-7-induced tumor suppression in MGC-803 and HGC-27 cells and led to a more aggressive oncogenic phenotype, via antagonizing miR-7-mediated PTEN/PI3K/AKT pathway."	2
Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance.	hsa_circ_0003159	hsa_circ_CACNA2D1	-	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	"Hsa_circ_0003159 expression levels were significantly negatively associated with gender, distal metastasis, and tumor-node-metastasis stage. Hsa_circ_0003159 may be a potential cancer marker of patients with gastric cancer."	3
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.	-	hsa_circ_SUSD1	circRNA_104871	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"Increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis."	2
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.	-	hsa_circ_FAM168B	circRNA_003524	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"Increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis."	2
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.	-	hsa_circ_GLG1	circRNA_101873	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"Increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis."	1
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.	-	hsa_circ_FAM168B	circRNA_103047	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"Increased expression of circRNAs circRNA_104871, circRNA_003524, circRNA_101873 and circRNA_103047 in PBMC from RA patients may serve as potential biomarkers for RA patient diagnosis."	2
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.	-	hsa_circ_XBP1	circRNA_092516	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"Consistent with the microarray data, the average expression levels of circRNA_092516, circRNA_003524, circRNA_103047, circRNA_104871, and circRNA_101873 in the PBMCs of patients with RA were significantly higher than those of the healthy controls."	1
A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation.	hsa_circ_0004214	hsa_circ_AMOTL1	-	DOID:1612	breast cancer	breast cancer	RT-qPCR	up-regulated	Single-cell inoculations using circ-Amotl1-transfected tumor cells showed a 30-fold increase in proliferative capacity relative to control. this potent tumorigenicity was triggered through interactions between circ-Amotl1 and c-myc.	2
A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation.	hsa_circ_0004214	hsa_circ_AMOTL1	-	DOID:0060108	brain glioma	glioma	RT-qPCR	up-regulated	Expression of circ-Amotl1 was analyzed in a variety of cell lines by real-time PCR. Nine cancer cell lines expressed higher levels of circ-Amotl1 relative to two non-cancer cell lines HaCaTand MCF-10A.	2
A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation.	hsa_circ_0004214	hsa_circ_AMOTL1	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	Expression of circ-Amotl1 was analyzed in a variety of cell lines by real-time PCR. Nine cancer cell lines expressed higher levels of circ-Amotl1 relative to two non-cancer cell lines HaCaTand MCF-10A.	3
A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation.	hsa_circ_0004214	hsa_circ_AMOTL1	-	DOID:1324	lung cancer	lung cancer	RT-qPCR	up-regulated	Expression of circ-Amotl1 was analyzed in a variety of cell lines by real-time PCR. Nine cancer cell lines expressed higher levels of circ-Amotl1 relative to two non-cancer cell lines HaCaTand MCF-10A.	1
Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.	-	-	hsa_circRNA_000598	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, microarray"	up-regulated	Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA.	1
Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.	-	-	hsa_circRNA_103387	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, microarray"	up-regulated	Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA.	1
Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.	-	-	hsa_circRNA_101975	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, microarray"	up-regulated	Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA.	1
Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.	-	-	circRNA_100226	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, microarray"	up-regulated	Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA.	1
Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma.	-	hsa_circ_ITCH	"cir-ITCH, circ-ITCH"	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	down-regulated	"Circ-ITCH may have an inhibitory effect on HCC, and could serve as susceptibility and prognostic biomarkers for HCC patients."	5
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0058246	hsa_circ_VIL1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"In particular, we found that the expression of hsa_circ_0058246 was elevated in tumor specimens of patients with poor clinical outcomes."	1
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0091742	hsa_circ_BGN	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible."	2
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0089548	hsa_circ_NOTCH1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible."	3
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0003707	hsa_circ_CD44	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible."	2
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0085553	hsa_circ_PVT1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible."	6
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0006022	hsa_circ_LYN	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible."	1
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0031979	hsa_circ_CDKN3	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible."	1
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0069131	hsa_circ_AFAP1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"To verify microarray expression data, expression of a number of circRNAs (hsa_circ_0058246, hsa_circ_0091742, hsa_circ_0089548, hsa_circ_0003707, hsa_circ_0085553, hsa_circ_0006022, hsa_circ_0031979, and hsa_circ_0069131) was detected via real-time PCR in advanced gastric cancer and corresponding adjacent tissues from patients provided by Fudan University Shanghai Cancer Center (Figure 2). Both methods consistently and successfully revealed differential expression of circRNAs in tumors of advanced gastric cancer patients relative to the corresponding adjacent tissues, indicating that the biochip findings are highly accurate and reproducible."	1
Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes.	-	-	hsa_circRNA_103827	DOID:1100	ovarian disease	ovarian aging	microarray	up-regulated	"Age-related up-regulation of circRNA_103827 and circRNA_104816 might be potential indicators of compromised follicular micro-environment which could be used to predict IVF prognosis, and improve female infertility management."	1
Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes.	-	-	hsa_circRNA_104816	DOID:1100	ovarian disease	ovarian aging	microarray	up-regulated	"Age-related up-regulation of circRNA_103827 and circRNA_104816 might be potential indicators of compromised follicular micro-environment which could be used to predict IVF prognosis, and improve female infertility management."	1
Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis.	hsa_circ_0005402	hsa_circ_ANXA2	hsa_circRNA_101539	DOID:2377	multiple sclerosis	multiple sclerosis	"RT-qPCR, microarray"	down-regulated	"We carried out expression profiling of 13617 circular RNA in peripheral blood leucocytes from multiple sclerosis patients and healthy controls finding 406 differentially expressed and demonstrate after validation that, circ_0005402 and circ_0035560 are underexpressed in multiple sclerosis patients and could be used as biomarkers of the disease."	2
Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis.	hsa_circ_0035560	hsa_circ_ANXA2	hsa_circRNA_101541	DOID:2377	multiple sclerosis	multiple sclerosis	"RT-qPCR, microarray"	down-regulated	"We carried out expression profiling of 13617 circular RNA in peripheral blood leucocytes from multiple sclerosis patients and healthy controls finding 406 differentially expressed and demonstrate after validation that, circ_0005402 and circ_0035560 are underexpressed in multiple sclerosis patients and could be used as biomarkers of the disease."	2
Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing.	-	hsa_circ_ANRIL	-	DOID:1909	melanoma	melanoma	RT-qPCR	dysregulated	we hypothesise that ANRIL has wholly distinct dual sets of functions in melanoma. This reveals the dynamic nature of the locus and constitutes a basis for investigating the functions of ANRIL in melanoma.	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0007031	hsa_circ_TUBGCP3	-	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, microarray"	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	4
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0000504	hsa_circ_TUBGCP3	-	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, microarray"	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	4
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0007006	hsa_circ_DYM	-	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, microarray"	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0000237	hsa_circ_HNRNPF	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0074930	hsa_circ_SLIT3	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0084353	hsa_circ_PRKDC	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	4
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0022080	hsa_circ_NUP160	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0008494	hsa_circ_ARID1A	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0005949	hsa_circ_ZNF608	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0074806	hsa_circ_CLINT1	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0048232	hsa_circ_DAZAP1	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	down-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0006174	hsa_circ_RAD23B	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	down-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	5
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0008509	hsa_circ_NAV3	-	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, microarray"	down-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0084021	hsa_circ_PLEKHA2	-	DOID:9256	colorectal cancer	colorectal cancer	"RT-qPCR, microarray"	down-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	1
Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0087862	hsa_circ_RAD23B	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	down-regulated	"To validate the microarray data, four upregulated and four downregulated circRNAs were selected as representatives for further validation by qRT-PCR using primers mentioned in Table 1. According to the data in Figure 3, five of the eight tested circRNAs yielded results quite similar to those of microarray; these well-validated circRNAs included three upregulated circRNAs, hsa_circ_0007031, hsa_circ_0000504, and hsa_circ_0007006."	4
Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances.	hsa_circ_0006633	hsa_circ_FGGY	-	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	Hsa_circ_0006633 may play an important role in gastric carcinogenesis and is also a potential biomarker for screening gastric cancer.	1
CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630.	-	hsa_circ_LPHN2	circRNA_100269	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	Overexpressing the circRNA_100269 plasmid inhibited cell proliferation. circRNA_100269 and miR-630 comprise a novel pathway that regulates proliferation of GC cells.	1
Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.	-	hsa_circ_SLC8A1	-	DOID:1287	cardiovascular system disease	cardiovascular disease	RNA-seq	up-regulated	"We validated the same circRNA dynamics for circRNAs from ATXN10, CHD7, DNAJC6 and SLC8A1 in biopsy material from human dilated cardiomyopathy (DCM) and control patients. Finally, we could show that rodent homologs of circMYOD, circSLC8A1, circATXN7 and circPHF21A interact with either the ribosome or Argonaute2 protein complexes."	1
Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.	-	hsa_circ_CHD7	-	DOID:1287	cardiovascular system disease	cardiovascular disease	RNA-seq	up-regulated	"We validated the same circRNA dynamics for circRNAs from ATXN10, CHD7, DNAJC6 and SLC8A1 in biopsy material from human dilated cardiomyopathy (DCM) and control patients. Finally, we could show that rodent homologs of circMYOD, circSLC8A1, circATXN7 and circPHF21A interact with either the ribosome or Argonaute3 protein complexes."	1
Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.	-	hsa_circ_ATXN10	-	DOID:1287	cardiovascular system disease	cardiovascular disease	RNA-seq	up-regulated	"We validated the same circRNA dynamics for circRNAs from ATXN10, CHD7, DNAJC6 and SLC8A1 in biopsy material from human dilated cardiomyopathy (DCM) and control patients. Finally, we could show that rodent homologs of circMYOD, circSLC8A1, circATXN7 and circPHF21A interact with either the ribosome or Argonaute4 protein complexes."	1
Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.	-	hsa_circ_DNAJ6C	-	DOID:1287	cardiovascular system disease	cardiovascular disease	RNA-seq	down-regulated	"We validated the same circRNA dynamics for circRNAs from ATXN10, CHD7, DNAJC6 and SLC8A1 in biopsy material from human dilated cardiomyopathy (DCM) and control patients. Finally, we could show that rodent homologs of circMYOD, circSLC8A1, circATXN7 and circPHF21A interact with either the ribosome or Argonaute5 protein complexes."	1
Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes.	-	-	hsa_circ_101396	DOID:936	brain disease	leukoaraiosis	"RT-qPCR, microarray"	up-regulated	The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research.	1
Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes.	-	-	hsa_circ_102533	DOID:936	brain disease	leukoaraiosis	"RT-qPCR, microarray"	up-regulated	The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research.	1
Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes.	-	-	hsa_circ_103783	DOID:936	brain disease	leukoaraiosis	"RT-qPCR, microarray"	up-regulated	The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research.	1
Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes.	-	-	hsa_circ_102470	DOID:936	brain disease	leukoaraiosis	"RT-qPCR, microarray"	down-regulated	The results of the present study indicated that the DE genes from differently expressed circRNAs may have an important role in the pathogenesis of LA and may be a novel targfet for further research.	1
Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension.	hsa_circ_0002062	hsa_circ_PTK2	-	DOID:6432	pulmonary hypertension	chronic thromboembolic pulmonary hypertension	microarray	down-regulated	"Combining these findings with the results of our present study showing that hsa_circ_0002062 regulated hsa-miR-942-5p, we suggested that circRNAs function in CTEPH via hsa_circ_0002062-hsa-miR-942-5p-CDK6-pathways involved in cancer."	1
Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension.	hsa_circ_0022342	hsa_circ_SYT7	-	DOID:6432	pulmonary hypertension	chronic thromboembolic pulmonary hypertension	microarray	down-regulated	"Combined with the results of our present study showing that hsa_circ_002234 regulated hsa-miR-940, we suggested that circRNAs play potential roles in CTEPH via the hsa_circ_0022342-hsa-miR-940-CRKL-ErbB signaling pathway."	1
Effect of Circular ANRIL on the Inflammatory Response of Vascular Endothelial Cells in a Rat Model of Coronary Atherosclerosis.	-	rno_circ_ANRIL	cANRIL	DOID:1936	atherosclerosis	atherosclerosis	RT-qPCR	up-regulated	Our study provides evidence that reduced cANRIL expression could prevent coronary AS by reducing vascular EC apoptosis and inflammatory factor expression.	1
hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma.	hsa_circ_0013958	hsa_circ_ACP6	-	DOID:1324	lung cancer	lung cancer	"RT-qPCR, microarray"	up-regulated	Hsa_circ_0013958 promoted cell proliferation and invasion and inhibited cell apoptosis in lung adenocarcinoma (LAC).	1
Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway.	hsa_circ_0002768	hsa_circ_MYLK	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"CircRNA-MYLK might function as competing endogenous RNA (ceRNA) for miR-29a, which could contribute to EMT and the development of bladder carcinoma through activating VEGFA/VEGFR2 and downstream Ras/ERK signaling pathway."	3
MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839.	-	-	circRNA_000839	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	up-regulated	"Our mechanistic data indicate that RhoA is a direct target of miR-200b, binding of which affects the expression of invasion and migration in hepatocellular carcinoma cell lines. And correlation analysis showed that miR-200b was inversely correlated with RhoA and circ_000839, while RhoA was positively correlated with circ_000839."	1
"Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p."	hsa_circ_0056288	hsa_circ_GLI2	-	DOID:3347	osteosarcoma	osteosarcoma	RT-qPCR	up-regulated	"Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p."	1
"Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1."	hsa_circ_0020397	hsa_circ_DOCK1	-	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	up-regulated	"Hsa_circ_0020397 can regulate colorectal cancer (CRC) cell viability, apoptosis, and invasion by promoting the expression of miR-138 target genes."	4
Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma.	-	hsa_circ_SNX27	hsa_circRNA_100338	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, microarray"	up-regulated	The crucial antagonistic roles of circRNA_100338 and miR-141-3p in the regulation of invasive potential in liver cancer cells.	3
Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma.	-	hsa_circ_NUP153	hsa_circRNA_104075	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, microarray"	up-regulated	"Despite the great genomic variations among the different patients, we were still able to identify two circRNAs (hsa_circRNA_104075 and hsa_circRNA_100338) that were significantly up-regulated in HCC samples compared with paired pericancerous tissue samples. These results further validated our findings and implied that these circRNAs may play important roles in HCC carcinogenesis."	1
Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis.	-	-	hsa_circRNA_002082	DOID:9452	fatty liver disease	hepatic steatosis	"RT-qPCR, microarray"	down-regulated	"In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014724 showed an opposite expression pattern."	1
Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis.	-	-	hsa_circRNA_000367	DOID:9452	fatty liver disease	hepatic steatosis	"RT-qPCR, microarray"	down-regulated	"In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014725 showed an opposite expression pattern."	1
Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis.	-	-	hsa_circRNA_004183	DOID:9452	fatty liver disease	hepatic steatosis	"RT-qPCR, microarray"	down-regulated	"In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014726 showed an opposite expression pattern."	1
Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis.	-	-	hsa_circRNA_007850	DOID:9452	fatty liver disease	hepatic steatosis	"RT-qPCR, microarray"	up-regulated	"In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014727 showed an opposite expression pattern."	1
Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis.	-	-	hsa_circRNA_004121	DOID:9452	fatty liver disease	hepatic steatosis	"RT-qPCR, microarray"	up-regulated	"In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014728 showed an opposite expression pattern."	1
Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis.	-	-	hsa_circRNA_014724	DOID:9452	fatty liver disease	hepatic steatosis	"RT-qPCR, microarray"	up-regulated	"In well consistence to the results of microarray hybridization, expression levels of hsa_circRNA_002082, hsa_circRNA_000367, and hsa_circRNA_004183 were downregulated in the model group rather than the normal one ,while hsa_circRNA_007850, hsa_circRNA_004121, and hsa_circRNA_014729 showed an opposite expression pattern."	1
Construction and analysis of circular RNA molecular regulatory networks in liver cancer.	hsa_circ_0072088	hsa_circ_ZFR	-	DOID:3571	liver cancer	liver cancer	"RT-qPCR, microarray"	up-regulated	"Representation of the data using an ROC plot showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively."	1
Construction and analysis of circular RNA molecular regulatory networks in liver cancer.	hsa_circ_0003028	hsa_circ_FUT8	-	DOID:3571	liver cancer	liver cancer	"RT-qPCR, microarray"	up-regulated	"Representation of the data using an ROC plot showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively."	1
Construction and analysis of circular RNA molecular regulatory networks in liver cancer.	hsa_circ_0007915	hsa_circ_IPO11	-	DOID:3571	liver cancer	liver cancer	"RT-qPCR, microarray"	up-regulated	"Representation of the data using an ROC plot showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively."	2
Expression profile of circular RNAs in human gastric cancer tissues.	hsa_circ_0000026	hsa_circ_EIF4G3	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues.	4
Expression profile of circular RNAs in human gastric cancer tissues.	hsa_circ_0005927	hsa_circ_VDAC3	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues.	2
Expression profile of circular RNAs in human gastric cancer tissues.	hsa_circ_0092341	hsa_circ_C6orf132	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues.	1
Expression profile of circular RNAs in human gastric cancer tissues.	hsa_circ_0000144	hsa_circ_SLAMF6	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues.	3
Expression profile of circular RNAs in human gastric cancer tissues.	hsa_circ_0061274	hsa_circ_NRIP1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues.	6
Expression profile of circular RNAs in human gastric cancer tissues.	hsa_circ_0032821	hsa_circ_CEP128	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues.	3
Expression profile of circular RNAs in human gastric cancer tissues.	hsa_circ_0005529	hsa_circ_VPS33B	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	A total of 3 upregulated circRNAs and 5 downregulated circRNAs were validated that show differential expression between gastric cancer tissues and adjacent normal tissues.	3
[Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1].	hsa_circ_0000284	hsa_circ_HIPK3	-	DOID:1324	lung cancer	lung cancer	RT-qPCR	up-regulated	CircHIPK3 could promote cell proliferation by a circHIPK3/miR-379 pathway in NCI-H1299 and NCI-H2170 cells and might be a potential tumor biomarker for NSCLC.	4
HIF1alpha-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment.	-	hsa_circ_DENND4C	-	DOID:1612	breast cancer	breast cancer	RT-qPCR	up-regulated	Knocking-down circDENND4C inhibited proliferation of breast cancer cells in a hypoxic environment.	2
Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271.	hsa_circ_0008717	hsa_circ_ABCB10	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"Results identified a new functional circ-ABCB10 in breast cancer tumorigenesis, and reveal the important regulatory role of circ-ABCB10 through sponging miR-1271, providing a novel insight for breast cancer pathogenesis."	2
Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells.	-	-	circ-104916	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	"Overexpression of circ-104916 effectively inhibited the proliferation, migration and invasion abilities of GC cells in vitro."	1
Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn.	-	-	rno_circRNA_013779	DOID:936	brain disease	neuropathic pain	"RT-qPCR, microarray"	up-regulated	CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.	1
Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn.	-	-	rno_circRNA_008646	DOID:936	brain disease	neuropathic pain	"RT-qPCR, microarray"	up-regulated	CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.	1
Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn.	-	-	rno_circRNA_35215	DOID:936	brain disease	neuropathic pain	"RT-qPCR, microarray"	up-regulated	CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.	1
Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn.	-	-	rno_circRNA_008973	DOID:936	brain disease	neuropathic pain	"RT-qPCR, microarray"	up-regulated	CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.	1
Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn.	-	-	rno_circRNA_011111	DOID:936	brain disease	neuropathic pain	"RT-qPCR, microarray"	down-regulated	CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.	1
Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn.	-	-	rno_circRNA_007419	DOID:936	brain disease	neuropathic pain	"RT-qPCR, microarray"	down-regulated	CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.	1
Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn.	-	-	rno_circRNA_007512	DOID:936	brain disease	neuropathic pain	"RT-qPCR, microarray"	down-regulated	CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.	1
Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn.	-	-	rno_circRNA_010913	DOID:936	brain disease	neuropathic pain	"RT-qPCR, microarray"	down-regulated	CCI resulted in a comprehensive expression profile of circRNAs in the spinal dorsal horn in rats. CircRNAs in the dorsal horn could be helpful to reveal molecular mechanisms of neuropathic pain.	1
Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer.	hsa_circ_0001445	hsa_circ_SMARCA5	-	DOID:10283	prostate cancer	prostate cancer	RT-qPCR	up-regulated	Functional experiments showed circ-SMARCA5 acted as an oncogene in prostate cancer by promoting cell cycle and inhibiting cell apoptosis.	2
Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0071410	hsa_circ_PALLD	-	DOID:409	liver disease	liver fibrosis	"RT-qPCR, microarray"	up-regulated	"Inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced hepatic stellate cell (HSC) activation."	1
Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0072765	hsa_circ_CCNB1	-	DOID:409	liver disease	liver fibrosis	"RT-qPCR, microarray"	up-regulated	"Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated."	2
Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0054345	hsa_circ_LRPPRC	-	DOID:409	liver disease	liver fibrosis	"RT-qPCR, microarray"	up-regulated	"Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated."	1
Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0070963	hsa_circ_SCLT1	-	DOID:409	liver disease	liver fibrosis	"RT-qPCR, microarray"	down-regulated	"Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated."	2
Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0061893	hsa_circ_PDXK	-	DOID:409	liver disease	liver fibrosis	"RT-qPCR, microarray"	down-regulated	"Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated."	1
Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0013255	hsa_circ_DPYD	-	DOID:409	liver disease	liver fibrosis	"RT-qPCR, microarray"	down-regulated	"Hsa_circ_0072765, hsa_circ_0071410, hsa_circ_0054345 were significantly up-regulated in irradiated hepatic stellate cell (HSC) compared with normal HSC, while hsa_circ_0070963, hsa_circ_0061893, hsa_circ_0013255 were significantly down-regulated."	1
Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	-	-	hsa-circRNA11783-2	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	down-regulated	The crude odds ratios and adjusted odds ratios of hsa-circRNA11783-2 showed significant differences in both the coronary artery disease group and type 2 diabetes mellitus group.	1
Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	-	-	hsa-circRNA11783-2	DOID:9352	type 2 diabetes mellitus	type 2 diabetes mellitus	"RT-qPCR, microarray"	down-regulated	The crude odds ratios and adjusted odds ratios of hsa-circRNA11783-2 showed significant differences in both the coronary artery disease group and type 2 diabetes mellitus group.	1
Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	-	-	hsa-circRNA11806-28	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	down-regulated	"The levels of hsa-circRNA11806-28, hsa-circRNA6510-1 and hsa-circRNA11783-2 were significantly lower in both the T2DM group and CAD group compared with the control group."	1
Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	-	-	hsa-circRNA11806-28	DOID:9352	type 2 diabetes mellitus	type 2 diabetes mellitus	"RT-qPCR, microarray"	down-regulated	"The levels of hsa-circRNA11806-28, hsa-circRNA6510-1 and hsa-circRNA11783-2 were significantly lower in both the T2DM group and CAD group compared with the control group."	1
Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	-	-	hsa-circRNA6510-1	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	down-regulated	"The levels of hsa-circRNA11806-28, hsa-circRNA6510-1 and hsa-circRNA11783-2 were significantly lower in both the T2DM group and CAD group compared with the control group."	1
Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	-	-	hsa-circRNA6510-1	DOID:9352	type 2 diabetes mellitus	type 2 diabetes mellitus	"RT-qPCR, microarray"	down-regulated	"The levels of hsa-circRNA11806-28, hsa-circRNA6510-1 and hsa-circRNA11783-2 were significantly lower in both the T2DM group and CAD group compared with the control group."	1
Circular RNAs in rat models of cardiovascular and renal diseases.	-	-	rno_circRNA_006016	DOID:10763	hypertension	hypertension	RT-qPCR	down-regulated	our study is the primary report of profiling circRNAs in renal tissue and illustrates that circRNAs could be candidate genetic factors controlling blood pressure.	1
Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 Levels.	-	-	circR-284	DOID:6713	cerebrovascular disease	carotid disease and ischemic stroke	RT-qPCR	up-regulated	Our data demonstrate that the serum ratio of circulating circR-284 to miR-221 is elevated in patients presenting with an acute carotid-related ischemic event and has the potential to serve as a diagnostic biomarker for carotid-related cerebrovascular ischemia.	1
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_003251	DOID:9351	diabetes mellitus	diabetes	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T2DM and could represent novel molecular targets for clinical diagnosis and therapy."	2
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_015115	DOID:9351	diabetes mellitus	diabetes	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T3DM and could represent novel molecular targets for clinical diagnosis and therapy."	2
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_100918	DOID:9351	diabetes mellitus	diabetes	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T4DM and could represent novel molecular targets for clinical diagnosis and therapy."	2
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_005019	DOID:9351	diabetes mellitus	diabetes	"RT-qPCR, microarray"	down-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T5DM and could represent novel molecular targets for clinical diagnosis and therapy."	2
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_003251	DOID:9351	diabetes mellitus	diabetes	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T6DM and could represent novel molecular targets for clinical diagnosis and therapy."	2
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_015115	DOID:9351	diabetes mellitus	diabetes	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T7DM and could represent novel molecular targets for clinical diagnosis and therapy."	2
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_100918	DOID:9351	diabetes mellitus	diabetes	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T8DM and could represent novel molecular targets for clinical diagnosis and therapy."	2
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_005019	DOID:9351	diabetes mellitus	diabetes	"RT-qPCR, microarray"	down-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T9DM and could represent novel molecular targets for clinical diagnosis and therapy."	2
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_003251	DOID:1596	depressive disorder	depression	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T10DM and could represent novel molecular targets for clinical diagnosis and therapy."	1
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_015115	DOID:1596	depressive disorder	depression	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T11DM and could represent novel molecular targets for clinical diagnosis and therapy."	1
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_100918	DOID:1596	depressive disorder	depression	"RT-qPCR, microarray"	up-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T12DM and could represent novel molecular targets for clinical diagnosis and therapy."	1
Relationships of circular RNA with diabetes and depression.	-	-	hsa_circRNA_005019	DOID:1596	depressive disorder	depression	"RT-qPCR, microarray"	down-regulated	"KEGG pathway analysis predicted that upregulation of hsa-circRNA_003251, hsa-circRNA_015115, hsa-circRNA_100918, and hsa_circRNA_001520 may participate in the thyroid hormone, Wnt, ErbB, and mitogen-activated protein kinase signalling pathways. We speculate that differentially expressed hsa-circRNAs could help us to clarify the pathogenesis of depression in patients with T13DM and could represent novel molecular targets for clinical diagnosis and therapy."	1
Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG.	-	hsa_circ_HIPK2	-	DOID:231	motor neuron disease	neuroinflammatory disorders	RT-qPCR	up-regulated	"the circular RNA HIPK2 (circHIPK2) functions as an endogenous microRNA-124 (MIR124-2HG) sponge to sequester MIR124-2HG and inhibit its activity, resulting in increased sigma non-opioid intracellular receptor 1 (SIGMAR1/OPRS1) expression."	1
CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.	hsa_circ_0000284	hsa_circ_HIPK3	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, RNA-seq"	down-regulated	"Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer cells in vitro and suppresses bladder cancer growth and metastasis in vivo."	4
"Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R."	hsa_circ_0045714	hsa_circ_UNK	-	DOID:8398	osteoarthritis	osteoarthritis	RT-qPCR	down-regulated	hsa_circ_0045714 can regulate extracellular matrix synthesis as well as proliferation and apoptosis of chondrocytes by promoting the expression of miR-193b target gene IGF1R. The findings will provide new proofs for studies on the applications of circRNA in OA and other orthopedic diseases.	4
Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0006528	hsa_circ_PRELID2	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	Hsa_circ_0006528 expression is significantly associated with ADM-resistant breast cancers and demonstrate the potential function of hsa_circ_0006528 in overcoming chemotherapy resistance in breast cancer.	4
Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0002113	hsa_circ_IFNGR2	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified."	1
Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0002874	hsa_circ_GLIS3	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified."	1
Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0001667	hsa_circ_HEATR2	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified."	4
Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0085495	hsa_circ_TMEM65	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified."	1
Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0086241	hsa_circ_RFX3	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified."	1
Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0092276	hsa_circ_NISCH	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified."	1
Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0003838	hsa_circ_TTBK2	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	down-regulated	"To confirm the results of the microarray profiling, we explored the expression levels of the 18 differentially expressed circRNAs in the MCF-7/ADM and MCF-7 cell lines using qRT-PCR. A total of seven upregulated (hsa_circ_0002113, hsa_circ_0002874, hsa_circ_0006528, hsa_circ_0001667, hsa_circ_0085495, hsa_circ_0086241 and hsa_circ_0092276) and one downregulated (hsa_circ_0003838) circRNAs were verified."	1
Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray.	-	-	hsa_circRNA_063981	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.	1
Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray.	-	-	hsa_circRNA_404457	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.	1
Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray.	-	-	hsa_circRNA_100750	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.	1
Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray.	-	-	hsa_circRNA_406918	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.	1
Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray.	-	-	hsa_circRNA_104387	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.	1
Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray.	-	-	hsa_circRNA_103410	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.	1
Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray.	-	-	hsa_circRNA_100192	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.	1
Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction.	-	hsa_circ_ZNF609	-	DOID:178	vascular disease	vascular endothelial dysfunction	RT-qPCR	up-regulated	"cZNF609 was significantly up-regulated upon high glucose and hypoxia stress in vivo and in vitro. cZNF609 silencing decreased retinal vessel loss and suppressed pathological angiogenesis in vivo. cZNF609 silencing increased endothelial cell migration and tube formation, and protected endothelial cell against oxidative stress and hypoxia stress in vitro."	1
Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0076304	hsa_circ_PGC	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in gastric cancer (GC). "	2
Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0035431	hsa_circ_CGNL1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in gastric cancer (GC). "	1
Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0076305	hsa_circ_PGC	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"Among differentially expressed circRNAs, hsa_circ_0076304, hsa_circ_0035431, and hsa_circ_0076305 had the highest magnitude of change. These results provided a preliminary landscape of circRNAs expression profile in gastric cancer (GC). "	2
The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis.	hsa_circ_0005836	hsa_circ_TRAPPC6B	-	DOID:399	tuberculosis	active tuberculosis	"RT-qPCR, RNA-seq"	down-regulated	"We found that the expression of hsa_circ_0005836 was down-regulated by 2.586 folds in the active pulmonary tuberculosis (APTB) patients compared to the health control group (P < 0.0001), which was consistent with the RNA-seq results."	2
The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis.	hsa_circ_0009128	hsa_circ_TXNDC11	-	DOID:399	tuberculosis	active tuberculosis	"RT-qPCR, RNA-seq"	down-regulated	The hsa_circ_0009128 was decreased in active pulmonary tuberculosis (APTB) patients on a larger cohort being different from that of smaller cohort.	1
Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus.	hsa_circ_0000284	hsa_circ_HIPK3	-	DOID:178	vascular disease	retinal vascular dysfunction	"RT-qPCR, RNA-seq"	up-regulated	"The circular RNA circHIPK3 plays a role in diabetic retinopathy by blocking miR-30a function, leading to increased endothelial proliferation and vascular dysfunction. These data suggest that circular RNA is a potential target to control diabetic proliferative retinopathy."	1
The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.	-	-	mmu_circRNA_19423	DOID:11394	adult respiratory distress syndrome	acute respiratory distress syndrome	"RT-qPCR, microarray"	up-regulated	"Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005564) exhibited significant validation."	1
The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.	-	-	rno_circRNA_010489	DOID:11394	adult respiratory distress syndrome	acute respiratory distress syndrome	"RT-qPCR, microarray"	up-regulated	"Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005565) exhibited significant validation."	1
The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.	-	-	rno_circRNA_011426	DOID:11394	adult respiratory distress syndrome	acute respiratory distress syndrome	"RT-qPCR, microarray"	up-regulated	"Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005566) exhibited significant validation."	1
The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.	-	-	mmu_circRNA_30664	DOID:11394	adult respiratory distress syndrome	acute respiratory distress syndrome	"RT-qPCR, microarray"	up-regulated	"Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005567) exhibited significant validation."	1
The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.	-	-	rno_circRNA_005564	DOID:11394	adult respiratory distress syndrome	acute respiratory distress syndrome	"RT-qPCR, microarray"	down-regulated	"Among them, only 4 up-regulated circRNAs (mmu_circRNA_19423, rno_circRNA_010489, rno_circRNA_011426, mmu_circRNA_30664) and 1 down-regulated circRNA (rno_circRNA_005568) exhibited significant validation."	1
Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, microarray"	down-regulated	CDR1as may exert its function by regulating EGFR expression via targeting miR-7 in HCC cells.	4
Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.	-	hsa_circ_LARP4	circ_101057	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	CircLARP4 was mainly localized in the cytoplasm and inhibited biological behaviors of GC cells by sponging miR-424. The expression of circLARP4 was downregulated in GC tissues and represented an independent prognostic factor for overall survival of GC patients.	1
Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis.	-	hsa_circ_FBXW7	-	DOID:0060108	brain glioma	glioma	"RT-qPCR, RNA-seq"	down-regulated	"Upregulation of FBXW7-185aa in cancer cells inhibited proliferation and cell cycle acceleration, while knockdown of FBXW7-185aa promoted malignant phenotypes in vitro and in vivo."	1
Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143.	hsa_circ_0001982	hsa_circ_RNF111	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, RNA-seq"	up-regulated	Loss-of-function and rescue experiments revealed that hsa_circ_0001982 knockdown suppressed breast cancer cell proliferation and invasion and induced apoptosis by targeting miR-143.	2
Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma.	hsa_circ_0004018	hsa_circ_SMYD4	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, microarray"	down-regulated	"Hsa_circ_0004018 was correlated with serum alpha-fetoprotein (AFP) level, tumor diameters, differentiation, Barcelona Clinic Liver Cancer stage and Tumor-node-metastasis stage."	3
Clinical values of circular RNA 0000181 in the screening of gastric cancer.	hsa_circ_0000181	hsa_circ_TATDN3	-	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	"Hsa_circ_0000181 expression in gastric cancer tissues was significantly correlated with tumor diameter, lymphatic metastasis, distal metastasis, and carbohydrate antigen 19-9."	1
Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis.	hsa_circ_0003575	hsa_circ_CHMP5	-	DOID:1936	atherosclerosis	atherosclerosis	RT-qPCR	up-regulated	"CircRNA microarray analysis reveals the expression profiles of HUVECs and verifies the role of hsa_circ_0003575 on HUVECs, providing a therapeutic strategy for vascular endothelial cell injury of atherosclerosis."	3
Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis.	hsa_circ_0003573	hsa_circ_C11orf41	-	DOID:1936	atherosclerosis	atherosclerosis	RT-qPCR	up-regulated	"Results showed that hsa_circ_0003573 and hsa_circ_0003204 were significantly up-regulated, while hsa_circ_0004264 and hsa_circ_0000345 were significantly down-regulated."	1
Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis.	hsa_circ_0003204	hsa_circ_USP36	-	DOID:1936	atherosclerosis	atherosclerosis	RT-qPCR	up-regulated	"Results showed that hsa_circ_0003573 and hsa_circ_0003204 were significantly up-regulated, while hsa_circ_0004264 and hsa_circ_0000345 were significantly down-regulated."	7
Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis.	hsa_circ_0004264	hsa_circ_NMD3	-	DOID:1936	atherosclerosis	atherosclerosis	RT-qPCR	down-regulated	"Results showed that hsa_circ_0003573 and hsa_circ_0003204 were significantly up-regulated, while hsa_circ_0004264 and hsa_circ_0000345 were significantly down-regulated."	2
Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis.	hsa_circ_0000345	hsa_circ_RSF1	-	DOID:1936	atherosclerosis	atherosclerosis	RT-qPCR	down-regulated	"Results showed that hsa_circ_0003573 and hsa_circ_0003204 were significantly up-regulated, while hsa_circ_0004264 and hsa_circ_0000345 were significantly down-regulated."	3
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0089378	hsa_circ_VAV2	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	1
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0083357	hsa_circ_CTSB	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	1
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0082824	hsa_circ_CUL1	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	1
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0068942	hsa_circ_ADD1	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	1
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0057576	hsa_circ_HECW2	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	2
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0054537	hsa_circ_PSME4	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	1
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0051172	hsa_circ_AXL	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	1
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0032970	hsa_circ_TC2N	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	1
Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0006323	hsa_circ_DPYD	-	DOID:3393	coronary artery disease	coronary artery disease	"RT-qPCR, microarray"	up-regulated	We have shown that 9 circRNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease (CAD) patients.	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_103801	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	up-regulated	"Functional analysis found that hsa_circRNA_103801 was involved in pathways in cancer, such as the HIF-1, VEGF and angiogenesis pathway, the Rap1 signaling pathway and the PI3K-Akt signaling pathway, while hsa_circRNA_104980 was related to some pathways such as the tight junction pathway."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_102049	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	up-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_103309	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	up-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_101113	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	up-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_102485	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	up-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_100241	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	up-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_104980	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	down-regulated	"Functional analysis found that hsa_circRNA_103801 was involved in pathways in cancer, such as the HIF-1, VEGF and angiogenesis pathway, the Rap1 signaling pathway and the PI3K-Akt signaling pathway, while hsa_circRNA_104980 was related to some pathways such as the tight junction pathway."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_104692	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	down-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_104892	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	down-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_102678	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	down-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_103110	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	down-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.	-	-	hsa_circRNA_100258	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	down-regulated	"There was a great consistency bewteen the real-time qPCR results and microarray analysis data. All the selected circRNAs were confirmed, which demonstrated the high reliability of the microarray expression data."	1
Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer.	hsa_circ_0043256	hsa_circ_ACACA	-	DOID:3908	lung non-small cell carcinoma	non-small cell lung cancer	"RT-qPCR, microarray"	up-regulated	"Hsa_circ_0043256 could inhibit cell proliferation and induce apoptosis, while hsa_circ_0043256 knock-down could promote cell proliferation and restrain apoptosis induced by Cinnamaldehyde (CA)."	3
Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia.	hsa_circ_0075001	hsa_circ_NPM1	-	DOID:9119	acute myeloid leukemia	acute myeloid leukemia	"RT-qPCR, RNA-seq"	up-regulated	"Hsa_circ_0075001 expression correlates positively with total NPM1 expression, but is independent of the NPM1 mutational status. High versus low hsa_circ_0075001 expression defines patient subgroups characterized by distinct gene expression patterns, such as lower expression of components of the Toll-like receptor signaling pathway in high hsa_circ_0075001 expression cases."	1
Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer.	hsa_circ_0000745	hsa_circ_SPECC1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, RNA-seq"	down-regulated	"The expression level of hsa_circ_0000745 in GC tissues correlated with tumor differentiation, while the expression level in plasma correlated with tumor-nodemetastasis stage."	2
Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer.	hsa_circ_0085616	hsa_circ_ASAP1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, RNA-seq"	up-regulated	Hsa_circ_0085616 was reported to be up-regulated in colorectal tissues compared to that in normal tissues.	1
Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer.	hsa_circ_0006127	hsa_circ_SRCAP	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, RNA-seq"	down-regulated	Hsa_circ_0006127 (chr16:30740286-30740893) were found to be down-regulated in GC tissues compared to paired adjacent non-tumor tissues.	1
Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.	-	hsa_circ_UBAP2	-	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	up-regulated	Increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both in vitro and in vivo. Our results suggest the roles of circUBAP2 in osteosarcoma development and implicate its potential in prognosis prediction and cancer therapy.	5
"Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer."	hsa_circ_0047905	hsa_circ_SERPINB5	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"Functional assays suggested that inhibition of these three circular RNAs (hsa_circ_0047905, hsa_circ_0138960 and hsa-circRNA7690-15) suppresses GC cell proliferation and invasion in vitro."	2
"Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer."	hsa_circ_0138960	hsa_circ_GDA	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"Functional assays suggested that inhibition of these three circular RNAs (hsa_circ_0047905, hsa_circ_0138960 and hsa-circRNA7690-15) suppresses GC cell proliferation and invasion in vitro."	2
"Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer."	-	hsa_circ_GDA	circRNA7690-15	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	up-regulated	"Functional assays suggested that inhibition of these three circular RNAs (hsa_circ_0047905, hsa_circ_0138960 and hsa-circRNA7690-15) suppresses GC cell proliferation and invasion in vitro."	2
"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0004712	hsa_circ_PDE7B	hsa_circRNA_104194	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA."	2
"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0083964	hsa_circ_ASH2L	hsa_circRNA_104593	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA."	3
"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0064996	hsa_circ_SNRK	hsa_circRNA_103334	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA."	1
"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0032683	hsa_circ_NEK9	hsa_circRNA_101407	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	up-regulated	"RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA."	1
"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0052012	hsa_circ_POLD1	hsa_circRNA_102594	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	"RT-qPCR, microarray"	down-regulated	"RT-qPCR validation demonstrated that the expression levels of hsa_circRNA_104194, hsa_circRNA_104593, hsa_circRNA_103334, hsa_circRNA_101407 and hsa_circRNA_102594 were consistent with the results from the microarray analysis. The current study presented differentially expressed circRNAs and their corresponding microRNA binding sites in RA. circRNAs may exhibit a role in the regulation of expression of symbol genes that influence the occurrence and development of RA."	1
Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.	hsa_circ_0008305	hsa_circ_PTK2	-	DOID:90	degenerative disc disease	intervertebral disc degeneration	RT-qPCR	up-regulated	"hsa_circ_0008305 upregulation and hsa_circ_0041946 downregulation were validated in IDD using reverse transcription_quantitative polymerase chain reaction. In conclusion, the findings of the present study may shed light on the potential roles of circRNAs in IDD and the possibility for their use in the diagnosis and clinical treatment of IDD in the future."	1
Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.	hsa_circ_0041946	hsa_circ_TP53	-	DOID:90	degenerative disc disease	intervertebral disc degeneration	RT-qPCR	down-regulated	"hsa_circ_0008305 upregulation and hsa_circ_0041946 downregulation were validated in IDD using reverse transcription_quantitative polymerase chain reaction. In conclusion, the findings of the present study may shed light on the potential roles of circRNAs in IDD and the possibility for their use in the diagnosis and clinical treatment of IDD in the future."	1
Altered expression of circular RNAs in Moyamoya disease.	-	-	hsa_circRNA_100914	DOID:13099	Moyamoya disease	moyamoya	"RT-qPCR, microarray"	down-regulated	"To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data."	1
Altered expression of circular RNAs in Moyamoya disease.	-	-	hsa_circRNA_103343	DOID:13099	Moyamoya disease	moyamoya	"RT-qPCR, microarray"	down-regulated	"To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data."	1
Altered expression of circular RNAs in Moyamoya disease.	-	-	hsa_circRNA_050898	DOID:13099	Moyamoya disease	moyamoya	"RT-qPCR, microarray"	down-regulated	"To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data."	1
Altered expression of circular RNAs in Moyamoya disease.	-	-	hsa_circRNA_101720	DOID:13099	Moyamoya disease	moyamoya	"RT-qPCR, microarray"	up-regulated	"To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data."	1
Altered expression of circular RNAs in Moyamoya disease.	-	-	hsa_circRNA_067209	DOID:13099	Moyamoya disease	moyamoya	"RT-qPCR, microarray"	up-regulated	"To validate the results of the microarray analysis, the expression levels of five circRNAs (hsa_circRNA_100914, hsa_circRNA_103343, hsa_circRNA_050898, hsa_circRNA_101720, and hsa_circRNA_067209) were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray (Fig. 2), confirming the reliability of the data."	1
circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis.	-	-	has-circRNA_0046367	DOID:9452	fatty liver disease	hepatic steatosis	RT-qPCR	down-regulated	"These findings indicate a circRNA_0046367/miR-34a/PPARalpha regulatory system underlying hepatic steatosis. Normalized expression of circRNA_0046367 may ameliorate the lipoxidative stress on the basis of steatosis attenuation. circRNA_0046367, therefore, is suggested to be potential approach to the therapy of lipid peroxidative damage."	1
circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a.	hsa_circ_0005239	hsa_circ_GFRA1	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	CircGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in triple negative breast cancer (TNBC). circGFRA1 may be a diagnostic biomarker and potential target for TNBC therapy.	3
Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.	-	-	hsa_circRNA_105055	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"It was demonstrated that hsa_circRNA_105055, hsa_circRNA_086376 and hsa_circRNA_102761 could commonly bind with miR-7 regulating target genes PRKCB, EPHA3, BRCA1 and ABCC1. The findings of the present study may provide a novel perspective on circRNA and lay a foundation for future research of potential roles of circRNA in (colorectal cancer) CRC with lung metastasis."	1
Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.	-	-	hsa_circRNA_086376	DOID:9256	colorectal cancer	colorectal cancer	microarray	down-regulated	"It was demonstrated that hsa_circRNA_105055, hsa_circRNA_086376 and hsa_circRNA_102761 could commonly bind with miR-7 regulating target genes PRKCB, EPHA3, BRCA1 and ABCC1. The findings of the present study may provide a novel perspective on circRNA and lay a foundation for future research of potential roles of circRNA in (colorectal cancer) CRC with lung metastasis."	1
Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.	-	-	hsa_circRNA_102761	DOID:9256	colorectal cancer	colorectal cancer	microarray	down-regulated	"It was demonstrated that hsa_circRNA_105055, hsa_circRNA_086376 and hsa_circRNA_102761 could commonly bind with miR-7 regulating target genes PRKCB, EPHA3, BRCA1 and ABCC1. The findings of the present study may provide a novel perspective on circRNA and lay a foundation for future research of potential roles of circRNA in (colorectal cancer) CRC with lung metastasis."	1
Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124.	-	hsa_circ_WDR77	-	DOID:1287	cardiovascular system disease	cardiovascular disease	microarray	up-regulated	CircRNAs expression profiles in high glucose induced VSMCs and identifies the role of circWDR77-miR-124-FGF2 regulatory pathway in VSMCs proliferation and migration.	1
Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection.	hsa_circ_0001785	hsa_circ_ELP3	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"Our study reveals that multiple circRNAs are closely correlated with breast cancer tumorigenesis, and thoroughly investigates the diagnostic value of hsa_circ_0001785, suggesting the promising biomarker for breast cancer detection."	3
Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection.	hsa_circ_0108942	hsa_circ_ANKRD12	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"Among these circRNAs, 3 candidate circRNAs were validated to be significantly dysregulated using RT-PCR, including hsa_circ_0001785, hsa_circ_0108942 and hsa_circ_0068033."	3
Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection.	hsa_circ_0068033	hsa_circ_NAALADL2	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	down-regulated	"Among these circRNAs, 3 candidate circRNAs were validated to be significantly dysregulated using RT-PCR, including hsa_circ_0001785, hsa_circ_0108942 and hsa_circ_0068034."	2
Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection.	hsa_circ_0043497	hsa_circ_MED24	-	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	up-regulated	"hsa_circ_0030045, hsa_circ_0001417 and hsa_circ_0043497 are significantly up-regulated in Mtb-infected group."	1
Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection.	hsa_circ_0030045	hsa_circ_SLC25A15	-	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	up-regulated	"hsa_circ_0030045, hsa_circ_0001417 and hsa_circ_0043497 are significantly up-regulated in Mtb-infected group."	1
Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection.	hsa_circ_0001417	hsa_circ_ANKRD17	-	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	up-regulated	"hsa_circ_0030045, hsa_circ_0001417 and hsa_circ_0043497 are significantly up-regulated in Mtb-infected group."	1
Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection.	hsa_circ_0030569	hsa_circ_ABCC4	-	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	down-regulated	hsa_circ_0030569 and hsa_circ_0001204 are significantly down-regulated in Mtb-infected group.	1
Identification of differentially expressed circular RNAs in human monocyte derived macrophages response to Mycobacterium tuberculosis infection.	hsa_circ_0001204	hsa_circ_DGCR8	-	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	down-regulated	hsa_circ_0030569 and hsa_circ_0001204 are significantly down-regulated in Mtb-infected group.	3
Circular RNA profile of infantile hemangioma by microarray analysis.	hsa_circ_0023984	hsa_circ_NOX4	-	DOID:255	hemangioma	infantile hemangioma	"RT-qPCR, microarray"	up-regulated	This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH.	1
Circular RNA profile of infantile hemangioma by microarray analysis.	hsa_circ_0003570	hsa_circ_FAM53B	-	DOID:255	hemangioma	infantile hemangioma	"RT-qPCR, microarray"	up-regulated	This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH.	1
Circular RNA profile of infantile hemangioma by microarray analysis.	hsa_circ_0079385	hsa_circ_ZDHHC4	-	DOID:255	hemangioma	infantile hemangioma	"RT-qPCR, microarray"	down-regulated	This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH.	1
Circular RNA profile of infantile hemangioma by microarray analysis.	hsa_circ_0003258	hsa_circ_ZNF652	-	DOID:255	hemangioma	infantile hemangioma	"RT-qPCR, microarray"	up-regulated	This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH.	1
Circular RNA profile of infantile hemangioma by microarray analysis.	hsa_circ_0051239	hsa_circ_ATP5SL	-	DOID:255	hemangioma	infantile hemangioma	"RT-qPCR, microarray"	up-regulated	This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH.	1
Circular RNA profile of infantile hemangioma by microarray analysis.	hsa_circ_0043138	hsa_circ_TAF15	-	DOID:255	hemangioma	infantile hemangioma	"RT-qPCR, microarray"	up-regulated	This is the first study to reveal the profiling of circRNAs in IH and pave the way for further characterization of the role of circRNAs in the pathogenesis of IH.	1
Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection.	hsa_circ_0001017	hsa_circ_XPO1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"We found that hsa_circ_0001017 and hsa_circ_0061276 both decreased in gastric cancer tissues and patients plasma. Moreover, their levels were tightly associated with main clinicopathological features of patients with gastric cancer. As a result, hsa_circ_0001017 and hsa_circ_0061276 may be valuable blood-based biomarkers, either alone or in combination, to screen gastric cancer and estimate prognosis."	1
Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection.	hsa_circ_0061276	hsa_circ_NRIP1	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"We found that hsa_circ_0001017 and hsa_circ_0061276 both decreased in gastric cancer tissues and patients plasma. Moreover, their levels were tightly associated with main clinicopathological features of patients with gastric cancer. As a result, hsa_circ_0001017 and hsa_circ_0061276 may be valuable blood-based biomarkers, either alone or in combination, to screen gastric cancer and estimate prognosis."	6
"Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma."	hsa_circ_0000520	hsa_circ_RPPH1	-	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	We first identified that hsa_circ_0000520 was significantly down-regulated in gastric cancer. Our study indicated hsa_circ_0000520 might serve as a novel biomarker for gastric cancer and is involved in gastric carcinoma development.	2
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.	-	hsa_circ_DLGAP4	-	DOID:2316	brain ischemia	acute ischemic injury	RT-qPCR	down-regulated	Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.	2
Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma.	hsa_circ_0009910	-	circ_0009910	DOID:3347	osteosarcoma	osteosarcoma	RT-qPCR	up-regulated	"we suggested that circ_0009910 acted as a sponge of miR-449a and upregulated miR-449a functional target IL6R, thereby contributed to carcinogenesis of OS."	1
The expression profile and clinical significance of circRNA0003906 in colorectal cancer.	hsa_circ_0003906	hsa_circ_None	circRNA0003906	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	down-regulated	CircRNA0003906 may be potentially involved in the colorectal cancerogenesis and serve as a potential biomarker for the diagnosis and treatment of CRC.	1
Circular RNA hsa_circ_0003221 (circPTK2) promotes the proliferation and migration of bladder cancer cells.	hsa_circ_0003221	hsa_circ_PTK2	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, RNA-seq"	up-regulated	"In vitro silence of circPTK2 by small interfering RNA inhibited the proliferation and migration of bladder cancer cells. On the contrary, circPTK2 overexpression promoted proliferation and migration."	4
Altered Circular RNA Expression in Patients with Repeated Implantation Failure.	-	-	hsa_circRNA_070616	DOID:1677	low implantation of placenta	repeated implantation failure	"RT-qPCR, microarray"	up-regulated	"The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR."	1
Altered Circular RNA Expression in Patients with Repeated Implantation Failure.	-	-	hsa_circRNA_103716	DOID:1677	low implantation of placenta	repeated implantation failure	"RT-qPCR, microarray"	up-regulated	"The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR."	1
Altered Circular RNA Expression in Patients with Repeated Implantation Failure.	-	-	hsa_circRNA_104001	DOID:1677	low implantation of placenta	repeated implantation failure	"RT-qPCR, microarray"	up-regulated	"The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR."	1
Altered Circular RNA Expression in Patients with Repeated Implantation Failure.	-	-	hsa_circRNA_104854	DOID:1677	low implantation of placenta	repeated implantation failure	"RT-qPCR, microarray"	up-regulated	"The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR."	1
Altered Circular RNA Expression in Patients with Repeated Implantation Failure.	-	-	hsa_circRNA_004183	DOID:1677	low implantation of placenta	repeated implantation failure	"RT-qPCR, microarray"	down-regulated	"The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR."	1
Altered Circular RNA Expression in Patients with Repeated Implantation Failure.	-	-	hsa_circRNA_044353	DOID:1677	low implantation of placenta	repeated implantation failure	"RT-qPCR, microarray"	down-regulated	"The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR."	1
Altered Circular RNA Expression in Patients with Repeated Implantation Failure.	-	-	hsa_circRNA_404686	DOID:1677	low implantation of placenta	repeated implantation failure	"RT-qPCR, microarray"	down-regulated	"The up-regulated expression of hsa_circRNA_070616, hsa_circRNA_103716, hsa_circRNA_104001, hsa_circRNA_104854 and the down-regulated expression of hsa_circRNA_004183, hsa_circRNA_044353, hsa_circRNA_404686 were further validated by qRT-PCR."	1
Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.	hsa_circ_0004372	hsa_circ_PAN3	-	DOID:0080685	aortic dissection	thoracic aortic dissection	"RT-qPCR, microarray"	up-regulated	"The luciferase reporter was constructed to determine whether hsa_circRNA_101238 can directly target the hsa-miR-320a. The luciferase signal of hsa-miR-320a was suppressed by the wild-type hsa_circRNA_101238, whereas the luciferase signal of hsa-miR-320a was not affected by the mutant hsa_circRNA_101238. Quantitative real-time PCR and Western blot manifested the low expression of hsa-miR-320a and high of MMP9 in human TAD tissues, respectively."	1
Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.	hsa_circ_0084615	hsa_circ_ASPH	-	DOID:0080685	aortic dissection	thoracic aortic dissection	"RT-qPCR, microarray"	up-regulated	"The upregulated hsa_circRNA_104634 and hsa_circRNA_104349 interacted with hsa-miR-145-3p and hsa-miR-26a-3p, respectively that have been demonstrated to increase SMC phenotype or apoptosis."	1
Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.	hsa_circ_0002271	hsa_circ_C2orf43	-	DOID:0080685	aortic dissection	thoracic aortic dissection	"RT-qPCR, microarray"	up-regulated	Upregulated significantly in human TAD as compared to NA.	1
Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.	hsa_circ_0055377	hsa_circ_CTNNA2	-	DOID:0080685	aortic dissection	thoracic aortic dissection	"RT-qPCR, microarray"	up-regulated	Upregulated significantly in human TAD as compared to NA.	1
Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.	hsa_circ_0079929	hsa_circ_CDK13	-	DOID:0080685	aortic dissection	thoracic aortic dissection	"RT-qPCR, microarray"	up-regulated	"The upregulated hsa_circRNA_104634 and hsa_circRNA_104349 interacted with hsa-miR-145-3p and hsa-miR-26a-3p, respectively that have been demonstrated to increase SMC phenotype or apoptosis."	1
Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.	hsa_circ_0007386	hsa_circ_CRIM1	-	DOID:0080685	aortic dissection	thoracic aortic dissection	"RT-qPCR, microarray"	down-regulated	"The downregulated hsa_circRNA_102683 and hsa_circRNA_104033 inhibited hsa-miR-29b-1-5p and hsa-miR-195-3p, respectively, which has been shown to target the aortic wall apoptosis and ECM degradation or stimulation of the collagen remodeling."	1
Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.	hsa_circ_0005525	hsa_circ_ATP8B1	-	DOID:0080685	aortic dissection	thoracic aortic dissection	"RT-qPCR, microarray"	down-regulated	Downregulated significantly in human TAD as compared to NA.	1
Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection.	hsa_circ_0067175	hsa_circ_ABTB1	-	DOID:0080685	aortic dissection	thoracic aortic dissection	"RT-qPCR, microarray"	down-regulated	Downregulated significantly in human TAD as compared to NA.	1
Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma.	hsa_circ_0085154	hsa_circ_PABPC1	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	microarray	down-regulated	"we found CircARSP91 (hsa_circ_0085154), one of the circRNAs downregulated by AR in an ADAR1-dependent manner, could inhibit HCC tumor growth both in vitro and in vivo. "	2
Identification of circular RNA signature in bladder cancer.	hsa_circ_0091017	hsa_circ_TAF1	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, RNA-seq"	down-regulated	"The expression level changes of hsa_circ_0091017 and hsa_circ_0002024 in the 32 paired samples were in accord with NGS data. In conclusion, we identified a set of circRNAs that are potentially implicated in the tumorigenesis of BCa (bladder cancer) and could serve as novel diagnostic markers for BCa."	2
Identification of circular RNA signature in bladder cancer.	hsa_circ_0092024	hsa_circ_FLNA	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, RNA-seq"	down-regulated	"The expression level changes of hsa_circ_0091017 and hsa_circ_0002024 in the 32 paired samples were in accord with NGS data. In conclusion, we identified a set of circRNAs that are potentially implicated in the tumorigenesis of BCa (bladder cancer) and could serve as novel diagnostic markers for BCa."	2
Screening circular RNA expression patterns following focal cerebral ischemia in mice.	-	-	mmu_circRNA_40001	DOID:6713	cerebrovascular disease	ischemic brain after stroke	"RT-qPCR, microarray"	up-regulated	"we constructed an interaction network of circRNA-miRNA-target genes, including 13 miRNAs and their corresponding genes, indicating that changes in circRNA are associated with genes related with brain injury and recovery. In conclusion, circRNAs are complicated in the pathological development of brain injury after stroke, suggesting novel diagnostic and therapeutic targets for stroke therapy."	1
Screening circular RNA expression patterns following focal cerebral ischemia in mice.	-	-	mmu_circRNA_013120	DOID:6713	cerebrovascular disease	ischemic brain after stroke	"RT-qPCR, microarray"	up-regulated	"we constructed an interaction network of circRNA-miRNA-target genes, including 14 miRNAs and their corresponding genes, indicating that changes in circRNA are associated with genes related with brain injury and recovery. In conclusion, circRNAs are complicated in the pathological development of brain injury after stroke, suggesting novel diagnostic and therapeutic targets for stroke therapy."	1
Screening circular RNA expression patterns following focal cerebral ischemia in mice.	-	-	mmu_circRNA_40806	DOID:6713	cerebrovascular disease	ischemic brain after stroke	"RT-qPCR, microarray"	down-regulated	"we constructed an interaction network of circRNA-miRNA-target genes, including 15 miRNAs and their corresponding genes, indicating that changes in circRNA are associated with genes related with brain injury and recovery. In conclusion, circRNAs are complicated in the pathological development of brain injury after stroke, suggesting novel diagnostic and therapeutic targets for stroke therapy."	1
Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis.	hsa_circ_0018289	hsa_circ_SYT15	-	DOID:4362	cervical cancer	cervical cancer	microarray	up-regulated	"Hsa_circ_0018289 plays important role in cervical cancer proliferation, migration and invasion, suggesting the miRNA sponge of hsa_circ_0018289 and its oncogenic role on cervical cancer tumorigenesis."	3
The circular RNA MICRA for risk stratification after myocardial infarction.	-	-	MICRA	DOID:5844	myocardial infarction	myocardial Infarction	RT-qPCR	down-regulated	we show that MICRA provides an incremental value to risk stratify patients after MI. Further prospective studies are warranted to confirm this predictive value and the clinical usefulness of this finding.	2
Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.	-	-	hsa_circ_402458	DOID:12236	primary biliary cholangitis	primary biliary cirrhosis	RT-qPCR	up-regulated	"Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082319 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR."	1
Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.	-	-	hsa_circ_087631	DOID:12236	primary biliary cholangitis	primary biliary cirrhosis	RT-qPCR	up-regulated	"Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082320 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR."	1
Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.	-	-	hsa_circ_406329	DOID:12236	primary biliary cholangitis	primary biliary cirrhosis	RT-qPCR	up-regulated	"Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082321 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR."	1
Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.	-	-	hsa_circ_407176	DOID:12236	primary biliary cholangitis	primary biliary cirrhosis	RT-qPCR	down-regulated	"Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082322 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR."	1
Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.	-	-	hsa_circ_082319	DOID:12236	primary biliary cholangitis	primary biliary cirrhosis	RT-qPCR	down-regulated	"Our results indicated that there were 18 up-regulated and 4 down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. Among the differentially expressed circRNAs, hsa_circ_402458 (P=0.0033), hsa_circ_087631 and hsa_circ_406329 (P=0.0185) were up-regulated, and hsa_circ_407176 (P=0.0066) and hsa_circ_082323 were down-regulated in the PBC group versus the healthy group as demonstrated by qRT-PCR."	1
Crosstalk in competing endogenous RNA network reveals the complex molecular mechanism underlying lung cancer.	-	-	circRNA4046	DOID:1324	lung cancer	lung cancer	RNA-seq	down-regulated	"Three circRNAs (circRNA4046, circRNA4882, and circRNA4406) were included in the TF regulatory network as miRNA targets."	1
Crosstalk in competing endogenous RNA network reveals the complex molecular mechanism underlying lung cancer.	-	-	circRNA4406	DOID:1324	lung cancer	lung cancer	RNA-seq	down-regulated	"Three circRNAs (circRNA4046, circRNA4882, and circRNA4406) were included in the TF regulatory network as miRNA targets."	1
Crosstalk in competing endogenous RNA network reveals the complex molecular mechanism underlying lung cancer.	-	-	circRNA4882	DOID:1324	lung cancer	lung cancer	RNA-seq	down-regulated	"Three circRNAs (circRNA4046, circRNA4882, and circRNA4406) were included in the TF regulatory network as miRNA targets."	1
Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b.	hsa_circ_0001724	hsa_circ_CDK6	hsa_circ_000984	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	up-regulated	"Further analysis revealed that hsa_circ_000984 knockdown could inhibit cell proliferation, migration, invasion in vitro and tumor formation in vivo in colorectal cancer (CRC) cell lines. Mechanically, we found that hsa_circ_000984 may act as a competing endogenous RNA (ceRNA) by competitively binding miR-106b and effectively upregulate the expression of CDK6, thereby inducing a series of malignant phenotypes of tumor cells."	1
Genome-Wide Search for Competing Endogenous RNAs Responsible for the Effects Induced by Ebola Virus Replication and Transcription Using a trVLP System.	-	-	circRNA-chr19	DOID:4325	Ebola hemorrhagic fever	ebola virus disease	RNA-seq	up-regulated	CircRNA-chr19 targeting miR-30b-3p regulated CLDN18 expression by functioning as a ceRNA.	1
CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes.	-	hsa_circ_LRP6	-	DOID:162	cancer	cancer	RNA-seq	up-regulated	"Thus, for HaCaT cells chronically exposed to arsenite, circLRP6 via miR-455 regulation of ZEB1 is involved in the EMT during malignant transformation. The results establish a previously unknown mechanism for arsenite-induced carcinogenesis."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA120	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 32 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA167	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 33 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA2918	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 34 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA3341	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 35 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA3594	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 36 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA3703	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 37 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA3706	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 38 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA3707	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 39 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA378	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 40 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA4628	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 41 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA5669	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 42 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA666	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 43 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7534	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 44 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7535	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 45 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7536	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 46 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7537	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 47 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7673	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 48 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7674	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 49 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7675	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 50 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7676	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 51 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA7679	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 52 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA8505	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 53 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA8506	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 54 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA8507	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 55 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA904	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 56 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA9227	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 57 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA9652	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 58 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA9656	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 59 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA9658	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 60 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA9671	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 61 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA9771	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 62 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.	-	-	circRNA9777	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"We identified 813 significantly up-regulated and 445 down-regulated circRNA candidates, of which 63 were subsequently validated by quantitative real-time reverse transcription polymerase chain reaction analysis. The differentially expressed circRNAs were found to be associated with pathways involved in metabolism, cell apoptosis, proliferation and migration, which are commonly altered in cancer cells."	1
Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.	-	hsa_circ_VRK1	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, RNA-seq"	down-regulated	"the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK1 might be a promising target for BCSCs."	2
Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.	-	hsa_circ_BRIP	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, RNA-seq"	down-regulated	"the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK2 might be a promising target for BCSCs."	1
Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.	-	hsa_circ_OLA	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, RNA-seq"	down-regulated	"the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK3 might be a promising target for BCSCs."	1
Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.	-	hsa_circ_ETFA	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, RNA-seq"	down-regulated	"the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK4 might be a promising target for BCSCs."	1
Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.	-	hsa_circ_MED13	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, RNA-seq"	down-regulated	"the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK5 might be a promising target for BCSCs."	1
Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.	-	hsa_circ_BCL11B	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, RNA-seq"	down-regulated	"the present work provides the first reported evidence of the circRNA profile and circRNA/miRNA interplay in BCSCs. In addition, these findings lay foundation to explore the functions of circRNAs in CSCs and indicate that circVRK6 might be a promising target for BCSCs."	1
Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer.	hsa_circ_0000064	hsa_circ_B4GALT2	-	DOID:1324	lung cancer	lung cancer	RT-qPCR	up-regulated	"Western blot analysis showed that the protein levels of caspase-3, caspase-9, bax, p21, CDK6 and cyclin D1 significantly restrained by si-hsa_circ_0000064, while the expression of bcl-2 notably increased in A549 and H1229 cells. Further, si-hsa_circ_0000064 also abated migration and invasion activities of A549 and H1229 cells, which may be associated with reduced expressions of MMP-2 and MMP-9. In general, our data suggest that hsa_circ_0000064 represents a novel potential biomarker and therapeutic target of lung cancer."	1
Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge.	hsa_circ_0001564	hsa_circ_CANX	-	DOID:3347	osteosarcoma	osteosarcoma	microarray	up-regulated	"Our study discovers that hsa_circ_0001564 acts as miR-29c-3p sponge to mediate the tumorigenicity, which could act as a potential biomarker for the osteosarcoma and provide a novel insight for competing endogenous RNAs (ceRNAs) mechanism in osteosarcoma."	1
Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values.	hsa_circ_0074362	hsa_circ_ARHGAP26	-	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	down-regulated	Hsa_circ_0074362 probably plays a role in the initiation of gastric cancer and may be a potential biomarker of gastric cancer.	3
CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients.	-	-	hsa_circRNA_404833	DOID:1324	lung cancer	lung cancer	"RT-qPCR, RNA-seq, microarray"	up-regulated	"This work illustrates that clusters of circRNAs are aberrantly expressed in early-stage lung adenocarcinoma, which might offer potential targets for the early diagnosis of this disease and new genetic insights into lung cancer."	1
CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients.	-	-	hsa_circRNA_006411	DOID:1324	lung cancer	lung cancer	"RT-qPCR, RNA-seq, microarray"	down-regulated	"This work illustrates that clusters of circRNAs are aberrantly expressed in early-stage lung adenocarcinoma, which might offer potential targets for the early diagnosis of this disease and new genetic insights into lung cancer."	1
CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients.	-	-	hsa_circRNA_401977	DOID:1324	lung cancer	lung cancer	"RT-qPCR, RNA-seq, microarray"	down-regulated	"This work illustrates that clusters of circRNAs are aberrantly expressed in early-stage lung adenocarcinoma, which might offer potential targets for the early diagnosis of this disease and new genetic insights into lung cancer."	1
Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.	-	-	mmu-circRNA-30365	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, RNA-seq"	down-regulated	"Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis."	1
Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.	-	-	mmu-circRNA-33736	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, RNA-seq"	down-regulated	"Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis."	1
Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.	-	-	mmu-circRNA-2483	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, RNA-seq"	down-regulated	"Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis."	1
Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.	-	-	mmu-circRNA-36866	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, RNA-seq"	up-regulated	"Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis."	1
Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.	-	-	mmu-circRNA-33186	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, RNA-seq"	up-regulated	"Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis."	1
Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.	-	-	mmu-circRNA-2443	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, RNA-seq"	up-regulated	"Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis."	1
Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.	-	-	mmu-circRNA-7063	DOID:8398	osteoarthritis	osteoarthritis	"RT-qPCR, RNA-seq"	up-regulated	"Although the exact mechanisms and biological functions of these circRNAs in the development of OA need further exploration, our findings do suggest that the differentially expressed circRNAs were involved in the pathogenesis of OA. Thus, our study brings us closer to understanding the pathogenic mechanisms and finding new molecular targets for the clinical treatment of osteoarthritis."	1
Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0000681	hsa_circ_PRKCB	-	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	"RT-qPCR, RNA-seq, microarray"	up-regulated	"we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management."	1
Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0008797	hsa_circ_GSK3B	-	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	"RT-qPCR, RNA-seq, microarray"	up-regulated	"we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management."	1
Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0002113	hsa_circ_IFNGR2	-	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	"RT-qPCR, RNA-seq, microarray"	up-regulated	"we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management."	1
Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0002362	hsa_circ_ASAP2	-	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	"RT-qPCR, RNA-seq, microarray"	up-regulated	"we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management."	1
Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0000414	hsa_circ_IRAK3	-	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	"RT-qPCR, RNA-seq, microarray"	up-regulated	"we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management."	1
Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0063179	hsa_circ_CSF2RB	-	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	"RT-qPCR, RNA-seq, microarray"	up-regulated	"we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management."	1
Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0002908	hsa_circ_PTK2	-	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	"RT-qPCR, RNA-seq, microarray"	up-regulated	"we suggested that PBMC circRNAs are potentially reliable marker molecules to diagnose active TB, which may have translational implications in TB management."	1
"CD90 promotes cell migration, viability and sphere_forming ability of hepatocellular carcinoma cells."	hsa_circ_0067531	hsa_circ_PIK3CB	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, microarray"	down-regulated	hsa_circ_0067531 may affect the biological functions of CD90+ HCC cells and may be a promising candidate to aid in the diagnosis and therapy of HCC.	1
CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway.	-	-	circRNA_100782	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	RT-qPCR	up-regulated	these results suggest that circRNA_100782 regulates BxPC3 cell proliferation by acting as miR-124 sponge through the IL6-STAT3 pathway.	1
Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer.	-	hsa_circ_BCRC4	circ_RNA BCRC4	DOID:11054	urinary bladder cancer	bladder cancer	RT-qPCR	down-regulated	"our findings suggest that BCRC4 functions as a tumor suppressor in BC, and mediates anticancer function, at least in part, by up-regulating the expression of miR-101. Targeting this newly identified circRNA may help us develop a novel strategy for treating human BC."	1
[Effect of Circular RNA UBAP2 Silencing on Proliferation and Invasion of Human Lung Cancer A549 Cells and Its Mechanism].	-	hsa_circ_UBAP2	-	DOID:1324	lung cancer	lung cancer	RT-qPCR	up-regulated	"We also found that after circUBAP2 silencing, cell invasion of A549 cells was significantly inhibited. Western blot and Real-time PCR results showed that expression of CDK6, cyclin D1, c-IAP1, Bcl-2, Survivin, FAK, Rac1 and MMP2 were down-regulated, and the expression of p27 and Bax were up-regulated. Moreover, the activities of JNK and ERK1/2 were inhibited because of circUBAP2 silencing, the target genes were miR-339-5p, miR-96-3p and miR-135b-3p."	1
CircDOCK1 suppresses cell apoptosis via inhibition of miR_196a_5p by targeting BIRC3 in OSCC.	-	hsa_circ_DOCK1	-	DOID:50866	oral squamous cell carcinoma	oral squamous cell carcinoma	"RT-qPCR, RNA-seq"	up-regulated	"Our results demonstrated that circDOCK1 regulated BIRC3 expression by functioning as a competing endogenous RNA(ceRNA) and participated in the process of OSCC apoptosis. Thus, we propose that circDOCK1 could represent a novel potential biomarker and therapeutic target of OSCC."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0005015	hsa_circ_HAS2	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0000615	hsa_circ_ZNF609	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	2
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0019069	hsa_circ_SLC16A12	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0066922	hsa_circ_HGD	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0081108	hsa_circ_COL1A2	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	4
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0081162	hsa_circ_COL1A2	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	4
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0087206	hsa_circ_ALDH1A1	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0087215	hsa_circ_ANXA1	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	up-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0041796	hsa_circ_C17orf81	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	down-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	2
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0072410	hsa_circ_NNT	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	down-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	2
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0026388	hsa_circ_KRT75	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	down-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0057093	hsa_circ_PDK1	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	down-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0030055	hsa_circ_MTRF1	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	down-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0026372	hsa_circ_KRT81	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	down-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy.	hsa_circ_0068489	hsa_circ_MASP1	-	DOID:8947	diabetic retinopathy	diabetic retinopathy	"RT-qPCR, microarray"	down-regulated	"CircRNAs are involved in DR pathogenesis, and thus serve as potential biomarkers of DR diagnosis."	1
circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination.	-	hsa_circ_HECTD1	-	DOID:10325	silicosis	silicosis	"RT-qPCR, microarray"	down-regulated	"Our study elucidated a link between SiO2-induced macrophage activation and the circHECTD1/HECTD1 pathway, thereby providing new insight into the potential use of HECTD1 in the development of novel therapeutic strategies for treating silicosis."	1
Circular RNA hsa_circ_0021001 in peripheral blood: a potential novel biomarker in the screening of intracranial aneurysm.	hsa_circ_0021001	hsa_circ_ARFIP2	-	DOID:10941	intracranial aneurysm	intracranial aneurysm	RT-qPCR	down-regulated	"We found for the first time that hsa_circ_0021001 decreased significantly in the peripheral blood of IA patients, which suggested that hsa_circ_0021001 might be used as a potential novel marker for the diagnosis of IA."	1
"Circular RNA Atp9b, a competing endogenous RNA, regulates the progression of osteoarthritis by targeting miR-138-5p."	-	mmu_circ_Atp9b	-	DOID:8398	osteoarthritis	osteoarthritis	RT-qPCR	up-regulated	"Taken together, these results suggest that circRNA_Atp9b regulates OA progression by modulating ECM catabolism and inflammation in chondrocytes via sponging miR-138-5p. Our findings provide novel insight into the regulatory mechanism of circRNA_Atp9b in OA and may contribute to establishing potential therapeutic strategies."	1
Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer.	-	hsa_circ_LDLRAD3	-	DOID:1793	pancreatic cancer	pancreatic cancer	RT-qPCR	up-regulated	"Circ-LDLRAD3 was up-regulated in pancreatic cancer cell lines (P < 0.01), pancreatic cancer tissues (P < 0.01), and plasma samples from patients with pancreatic cancer (P < 0.01). High expression of circ-LDLRAD3 was significantly associated with venous invasion, lymphatic invasion, and metastasis. The area under the ROC curve of circ-LDLRAD3 alone or combination with CA19-9 was 0.67 and 0.87, respectively, with a sensitivity and specificity of 0.5738 (alone) and 0.7049 (alone), and 0.8033 (combination) and 0.9355 (combination), respectively."	2
Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer.	hsa_circ_0000567	hsa_circ_SETD3	-	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	down-regulated	Hsa_circ_0000567 may be a novel suppressor and a potential diagnosis biomarker in CRC.	2
Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer.	hsa_circ_0109046	hsa_circ_ZNF700	-	DOID:1380	endometrial cancer	endometrial cancer	"RT-qPCR, RNA-seq"	up-regulated	We identified 275 differentially expressed circRNAs and the expression level of two circRNAs was confirmed using real-time quantitative PCR.	2
Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer.	hsa_circ_0002577	hsa_circ_WDR26	-	DOID:1380	endometrial cancer	endometrial cancer	"RT-qPCR, RNA-seq"	up-regulated	We identified 275 differentially expressed circRNAs and the expression level of two circRNAs was confirmed using real-time quantitative PCR.	4
Circular RNA expression in ovarian endometriosis.	hsa_circ_0062557	hsa_circ_CHCHD10	-	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"The circRNA 0062557 and circRNA 0026143 were overexpressed in EC, consistent with the data from microarray; however, there is no statistical significance. The data confirmed that circRNA 0023115 and circRNA 0000673 were significantly lower expressed, with 5.7-and 1.7 fold change downregulated in EC compared with EU (p < 0.05)."	1
Circular RNA expression in ovarian endometriosis.	hsa_circ_0026143	hsa_circ_TROAP	-	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"The circRNA 0062557 and circRNA 0026143 were overexpressed in EC, consistent with the data from microarray; however, there is no statistical significance. The data confirmed that circRNA 0023115 and circRNA 0000673 were significantly lower expressed, with 5.7-and 1.7 fold change downregulated in EC compared with EU (p < 0.05)."	1
Circular RNA expression in ovarian endometriosis.	hsa_circ_0023115	hsa_circ_GSTP1	-	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	down-regulated	"The circRNA 0062557 and circRNA 0026143 were overexpressed in EC, consistent with the data from microarray; however, there is no statistical significance. The data confirmed that circRNA 0023115 and circRNA 0000673 were significantly lower expressed, with 5.7-and 1.7 fold change downregulated in EC compared with EU (p < 0.05)."	1
Circular RNA expression in ovarian endometriosis.	hsa_circ_0000673	hsa_circ_RSL1D1	-	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	down-regulated	"The circRNA 0062557 and circRNA 0026143 were overexpressed in EC, consistent with the data from microarray; however, there is no statistical significance. The data confirmed that circRNA 0023115 and circRNA 0000673 were significantly lower expressed, with 5.7-and 1.7 fold change downregulated in EC compared with EU (p < 0.05)."	1
"A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma."	hsa_circ_0046701	hsa_circ_YES1	-	DOID:0060108	brain glioma	glioma	RT-qPCR	up-regulated	The results demonstrated that the hsa_circ_0046701/miR-142-3p/ITGB8 axis might play critical regulatory roles in the pathogenesis and development of glioma.	1
"Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells."	hsa_circ_0001649	hsa_circ_SHPRH	-	DOID:4947	cholangiocarcinoma	cholangiocarcinoma	RT-qPCR	down-regulated	"Furthermore, tumor xenograft study confirmed the in_itro results. Collectively, our findings suggest that hsa_circ_0001649 might be a rational CCA-related therapeutic target."	1
Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein.	-	hsa_circ_VMA21	-	DOID:90	degenerative disc disease	intervertebral disc degeneration	RT-qPCR	down-regulated	CircVMA21 could alleviate inflammatory cytokines-induced NP cell apoptosis and imbalance between anabolism and catabolism of extracellular matrix through miR-200c-XIAP pathway. It provides a potentially effective therapeutic strategy for IVDD.	1
A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.	-	hsa_circ_SHPRH	circ-SHPRH	DOID:0060108	brain glioma	glioma	RT-qPCR	down-regulated	"Our findings provide a novel perspective regarding circRNA function in physiological and pathological processes. Specifically, SHPRH-146aa generated from overlapping genetic codes of circ-SHPRH is a tumor suppressor in human glioblastoma."	2
Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats.	-	-	rno_circRNA_006508	DOID:81292	traumatic brain injury	traumatic brain injury	microarray	up-regulated	"The circRNAs rno_circRNA_006508 and rno_circRNA_010705 were observed to be upregulated, and rno_circRNA_001167 and rno_circRNA_001168 were observed to be downregulated significantly after TBI."	1
Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats.	-	-	rno_circRNA_010705	DOID:81292	traumatic brain injury	traumatic brain injury	microarray	up-regulated	"The circRNAs rno_circRNA_006508 and rno_circRNA_010705 were observed to be upregulated, and rno_circRNA_001167 and rno_circRNA_001168 were observed to be downregulated significantly after TBI."	1
Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats.	-	-	rno_circRNA_001167	DOID:81292	traumatic brain injury	traumatic brain injury	microarray	down-regulated	"The circRNAs rno_circRNA_006508 and rno_circRNA_010705 were observed to be upregulated, and rno_circRNA_001167 and rno_circRNA_001168 were observed to be downregulated significantly after TBI."	1
Circular RNA Expression Profiles Alter Significantly after Traumatic Brain Injury in Rats.	-	-	rno_circRNA_001168	DOID:81292	traumatic brain injury	traumatic brain injury	microarray	down-regulated	"The circRNAs rno_circRNA_006508 and rno_circRNA_010705 were observed to be upregulated, and rno_circRNA_001167 and rno_circRNA_001168 were observed to be downregulated significantly after TBI."	1
Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0092374	hsa_circ_GADD45A	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	up-regulated	we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future.	1
Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0003146	hsa_circ_EHD2	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	up-regulated	we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future.	1
Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0034398	hsa_circ_C15orf41	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	up-regulated	we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future.	1
Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0001866	hsa_circ_UBQLN1	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	up-regulated	we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future.	1
Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0008615	hsa_circ_PPP1R13L	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	up-regulated	we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future.	1
Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0046599	hsa_circ_B3GNTL1	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	down-regulated	we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future.	1
Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0021549	hsa_circ_MPPED2	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	down-regulated	we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future.	1
Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0040705	hsa_circ_USP10	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	down-regulated	we firstly illustrate the comprehensive expression profiles of circRNAs in SLE patients plasma and lay the foundations to develop circRNAs as novel non-invasive biomarkers for SLE disease in the future.	1
Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN.	-	hsa_circ_ZFR	-	DOID:10534	stomach cancer	gastric cancer	"RT-qPCR, microarray"	down-regulated	"Circ-ZFR restrained GC cell proliferation, induced cell cycle arrest and promoted apoptosis by sponging miR-130a/miR-107 and regulating PTEN."	1
"Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson Disease."	-	cel_circ_zip-2	circzip-2	DOID:14330	Parkinson disease	Parkinson disease	RT-qPCR	down-regulated	Further interaction studies revealed that circzip-2 possibly sponges microRNA molecule miR-60 towards asserting an important role in various processes associated with PD.	1
Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells.	hsa_circ_0007534	hsa_circ_DDX42	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	Hsa_circ_0007534 plays a crucial role in the initiation and progression of CRC and may be a potential therapeutic target of CRC.	3
Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation.	hsa_circ_0012673	hsa_circ_DHCR24	-	DOID:1324	lung cancer	lung cancer	microarray	up-regulated	"Furthermore, hsa_circ_0012673 was primarily localized in the cytoplasm and promoted cell proliferation of LAC cells by sponging miR-22, which targeted erb-b2 receptor tyrosine kinase 3 (ErbB3) in LAC. Hsa_circ_0012673 promotes LAC proliferation by suppressing miR-22, which targets ErbB3."	2
Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.	-	-	circRNA_14623	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	RNA-seq	up-regulated	"hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB."	1
Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.	-	-	circRNA_09585	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	RNA-seq	up-regulated	"hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB."	1
Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.	-	-	circRNA_05538	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	RNA-seq	down-regulated	"hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB."	1
Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.	-	-	circRNA_09993	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	RNA-seq	down-regulated	"hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB."	1
Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.	-	-	circRNA_13478	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	RNA-seq	down-regulated	"hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB."	1
Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.	-	-	circRNA_00074	DOID:2957	pulmonary tuberculosis	pulmonary tuberculosis	RNA-seq	up-regulated	"hsa_ circRNA_14623, hsa_circ_09585, hsa_circ_005538, hsa_circ_09993, hsa_circ_00074 and hsa_circ_13478 were confirmed as significantly dysregulated in PTB."	1
Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis.	hsa_circ_0007385	hsa_circ_MEMO1	-	DOID:3908	lung non-small cell carcinoma	non-small cell lung cancer	"RT-qPCR, microarray"	up-regulated	"In summary, results suggest hsa_circ_0007385 plays a role in NSCLC tumorigenesis, providing a potential therapeutic target for NSCLC."	5
Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma.	hsa_circ_0001445	hsa_circ_SMARCA5	cSMARCA5	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, RNA-seq"	down-regulated	"Herein, we studied the role of cSMARCA5, a circular RNA, in hepatocellular carcinoma. Our in vitro and in vivo data showed that cSMARCA5 inhibits the growth and migration of hepatocellular carcinoma cells, making it a potential therapeutic target."	3
Circular RNA circ-NT5C2 acts as an oncogene in osteosarcoma proliferation and metastasis through targeting miR-448.	-	hsa_circ_NT5C2	-	DOID:3347	osteosarcoma	osteosarcoma	"RT-qPCR, microarray"	up-regulated	"our study investigates the circRNAs expression profiles and determines the function of circ-NT5C2 in osteosarcoma tumorigenesis, which might serve as a novel therapeutic target of osteosarcoma patients."	2
"Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression."	-	hsa_circ_ITCH	"cir-ITCH, circ-ITCH"	DOID:11054	urinary bladder cancer	bladder cancer	RT-qPCR	down-regulated	"Circ-ITCH acts as a tumor suppressor by a novel circ-ITCH/miR-17, miR-224/p21, PTEN axis, which may provide a potential biomarker and therapeutic target for the management of BCa."	1
circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling.	-	-	circRNA_0046366	DOID:9452	fatty liver disease	hepatocellular steatosis	RT-qPCR	down-regulated	Dysregulation of circRNA_0046366/miR-34a/PPARalpha signaling may be a novel epigenetic mechanism underlying hepatocellular steatosis. circRNA_0046366 serves as a potential target for the treatment of hepatic steatosis.	1
Circular RNAs as novel regulators of beta-cell functions in normal and disease conditions.	hsa_circ_0000284	hsa_circ_HIPK3	-	DOID:9351	diabetes mellitus	diabetes	microarray	down-regulated	Our findings point to circular RNAs as novel regulators of beta-cell activities and suggest an involvement of this novel class of non-coding RNAs in beta-cell dysfunction under diabetic conditions.	2
Circular RNAs as novel regulators of beta-cell functions in normal and disease conditions.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:9351	diabetes mellitus	diabetes	microarray	down-regulated	Our findings point to circular RNAs as novel regulators of beta-cell activities and suggest an involvement of this novel class of non-coding RNAs in beta-cell dysfunction under diabetic conditions.	1
Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation.	-	hsa_circ_ZC3H4	-	DOID:10325	silicosis	silicosis	RT-qPCR	up-regulated	"Our study elucidates a link between SiO2-induced macrophage activationand the circZC3H4 RNA/ZC3H4 pathway, thereby providing novel insight into the potentialuse of ZC3H4 to develop novel therapeutic strategies for silicosis."	2
Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma.	-	-	circ_0015756	DOID:687	hepatoblastoma	hepatoblastoma	microarray	up-regulated	"CircRNAs are involved in the pathogenesis of hepatoblastoma. circ_0015756 is a promising target for the prognosis, diagnosis, and treatment of hepatoblastoma."	1
CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB.	hsa_circ_0001445	hsa_circ_SMARCA5	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	RT-qPCR	down-regulated	"Collectively, our data show circSMARCA5 as a promising druggable tumor suppressor in GBM and suggest that it may exert its function by tethering the RBP SRSF1."	3
circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma.	hsa_circ_0000284	hsa_circ_HIPK3	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	up-regulated	CircHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma.	6
Hsa_circ_0001649: A circular RNA and potential novel biomarker for colorectal cancer.	hsa_circ_0001649	hsa_circ_SHPRH	-	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	down-regulated	"In conclusion, this study showed that the expression level of hsa_circ_0001649 was down-regulated in CRC and could use it as a new biomarker for specific and sensitive inspection of CRC."	1
A novel prognostic biomarker for cholangiocarcinoma: circRNA Cdr1as.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:4947	cholangiocarcinoma	cholangiocarcinoma	RT-qPCR	up-regulated	Our finding suggested that circRNA Cdr1as may serve as a potential vicious molecular biomarker to predict the aggressive tumor progression and worse prognosis for CCA patients.	2
Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis.	-	-	circRNA-000911	DOID:1612	breast cancer	breast cancer	microarray	down-regulated	"On the whole, our findings indicate that circRNA-000911 plays an anti-oncogenic role in breast cancer and may thus serve as a promising therapeutic target for patients with breast cancer. Therefore, the overexpression of circRNA-000911 may provide a future direction which may aid in the development of a novel treatment strategy for breast cancer."	1
Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	-	-	circ0000082	DOID:1909	melanoma	melanoma	"RT-qPCR, microarray"	up-regulated	"The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma."	1
Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	-	-	circ0016418	DOID:1909	melanoma	melanoma	"RT-qPCR, microarray"	up-regulated	"The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma."	1
Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	-	-	circ0023988	DOID:1909	melanoma	melanoma	"RT-qPCR, microarray"	down-regulated	"The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma."	1
Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	-	-	circ0008157	DOID:1909	melanoma	melanoma	"RT-qPCR, microarray"	down-regulated	"The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma."	1
Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	-	-	circ0030388	DOID:1909	melanoma	melanoma	"RT-qPCR, microarray"	down-regulated	"The present study revealed several differentially expressed circRNAs, indicating that the newly identified circRNAs may provide new therapeutic targets for melanoma."	1
Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer.	hsa_circ_0014130	hsa_circ_PIP5K1A	-	DOID:3908	lung non-small cell carcinoma	non-small cell lung cancer	"RT-qPCR, microarray"	up-regulated	"In summary, our findings indicated that hsa_circ_0014130 could be used as a potential NSCLC biomarker and might be closely related to the carcinogenesis of NSCLC."	4
Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model.	-	-	mmu_circRNA_017963	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	down-regulated	"The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1."	1
Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model.	-	-	mmu_circRNA_003540	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	up-regulated	"The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1."	1
Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model.	-	-	mmu_circRNA_013699	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	down-regulated	"The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1."	1
Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model.	-	-	mmu_circRNA_012180	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	up-regulated	"The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1."	2
Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model.	-	-	mmu_circRNA_006173	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	down-regulated	"The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1."	1
Comprehensive analysis of differentially expressed profiles of Alzheimer disease associated circular RNAs in an Alzheimer disease mouse model.	-	-	mmu_circRNA_006229	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	up-regulated	"The results of qPCR assay showed that five (mmu_circRNA_017963, mmu_circRNA_003540, mmu_circRNA_013699, mmu_circRNA_012180 and mmu_circRNA_006173) out of the six circRNAs significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1."	1
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.	-	-	hsa_circRNA_001937	DOID:399	tuberculosis	active tuberculosis	"RT-qPCR, microarray"	up-regulated	"This study identified a set of deregulated circRNAs in active TB PBMCs, our data also suggest that hsa_circRNA_001937 can be used as a potential diagnostic biomarker of TB."	2
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.	-	-	hsa_circRNA_009024	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	up-regulated	"Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. "	1
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.	-	-	hsa_circRNA_001937	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	up-regulated	"Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. "	2
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.	-	-	hsa_circRNA_005086	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	up-regulated	"Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. "	1
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.	-	-	hsa_circRNA_102101	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	down-regulated	"Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. "	1
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.	-	-	hsa_circRNA_104964	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	down-regulated	"Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. "	1
Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.	-	-	hsa_circRNA_104296	DOID:399	tuberculosis	tuberculosis	"RT-qPCR, microarray"	down-regulated	"Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. "	1
Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression.	hsa_circ_0000977	hsa_circ_NOL10	-	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression.	2
CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/beta-catenin axis.	hsa_circ_0067934	-	circ_0067934	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	up-regulated	the circ_0067934/miR-1324/FZD5/beta-catenin signaling axis might serve as a promising therapeutic target for HCC intervention.	2
Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis.	hsa_circ_0087537	hsa_circ_FAM120A	-	DOID:8398	osteoarthritis	facet joint osteoarthritis	"RT-qPCR, microarray"	up-regulated	Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR.	1
Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis.	hsa_circ_0072668	hsa_circ_ADAMTS6	-	DOID:8398	osteoarthritis	facet joint osteoarthritis	"RT-qPCR, microarray"	up-regulated	Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR.	2
Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis.	hsa_circ_0071896	hsa_circ_TRIO	-	DOID:8398	osteoarthritis	facet joint osteoarthritis	"RT-qPCR, microarray"	up-regulated	Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR.	2
Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis.	hsa_circ_0063781	hsa_circ_PPARA	-	DOID:8398	osteoarthritis	facet joint osteoarthritis	"RT-qPCR, microarray"	up-regulated	Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR.	1
Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis.	hsa_circ_0053743	hsa_circ_BIRC6	-	DOID:8398	osteoarthritis	facet joint osteoarthritis	"RT-qPCR, microarray"	up-regulated	Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR.	1
Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis.	hsa_circ_0029067	hsa_circ_CLIP1	-	DOID:8398	osteoarthritis	facet joint osteoarthritis	"RT-qPCR, microarray"	down-regulated	Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR.	1
Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis.	hsa_circ_0005127	hsa_circ_REXO2	-	DOID:8398	osteoarthritis	facet joint osteoarthritis	"RT-qPCR, microarray"	down-regulated	Seven circRNAs were arbitrarily selected to confirm their differential expression levels by qRT-PCR.	1
Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk.	-	hsa_circ_GRB10	-	DOID:90	degenerative disc disease	intervertebral disc degeneration	"RT-qPCR, microarray"	down-regulated	"the present study revealed that circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD."	3
Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis.	hsa_circ_0004712	-	circ_0004712	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"This study provides evidence that circRNAs are differentially expressed between eutopic and normal endometrium, which suggests that circRNAs are candidate factors in the activation of endometriosis. circ_0002198 and circ_0004712 may be potential novel biomarkers for the diagnosis of ovarian endometriosis."	2
Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis.	hsa_circ_0002198	-	circ_0002198	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"This study provides evidence that circRNAs are differentially expressed between eutopic and normal endometrium, which suggests that circRNAs are candidate factors in the activation of endometriosis. circ_0002198 and circ_0004712 may be potential novel biomarkers for the diagnosis of ovarian endometriosis."	3
The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0004712	-	circ_0004712	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets."	2
The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0002198	-	circ_0002198	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets."	3
The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0002503	-	circ_0002503	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets."	1
The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0000284	-	circ_0000284	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	down-regulated	"This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets."	1
The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0003570	-	circ_0003570	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	down-regulated	"This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets."	1
The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0008951	-	circ_0008951	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets."	1
The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0017248	-	circ_0017248	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	up-regulated	"This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets."	1
The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0034762	-	circ_0034762	DOID:11432	endometriosis of ovary	ovarian endometriosis	"RT-qPCR, microarray"	down-regulated	"This is the first study of circRNA expression patterns in ovarian endometriosis, which suggests that circRNAs are candidate factors in the activation of ovarian endometriosis and are promising diagnostic biomarkers and treatment targets."	1
ERbeta-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma.	-	hsa_circ_ATP2B1	-	DOID:4467	clear cell renal cell carcinoma	clear cell renal cell carcinoma	RT-qPCR	down-regulated	"These results identify an ERbeta/circATP2B1/miR-204-3p/FN1 signaling axis in RCC, suggesting ERbeta and circular RNA ATP2B1 as prognostic biomarkers for this disease."	1
circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.	-	hsa_circ_HLA-C	-	DOID:0080162	lupus nephritis	lupus nephritis	"RT-qPCR, microarray"	up-regulated	CircHLA-C may play an important role in the pathogenesis of lupus nephritis by sponging miR-150.	1
circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways.	-	hsa_circ_SHKBP1	circ-SHKBP1	DOID:0060108	brain glioma	glioma	RT-qPCR	up-regulated	"the present study demonstrated that circ-SHKBP1 regulated the angiogenesis of GECs through miR-544a/FOXP1 and miR-379/FOXP2 pathways, and these findings might provide a potential target and effective strategy for combined therapy of gliomas."	2
Profiles of circular RNAs in human placenta and their potential roles related to preeclampsia.	hsa_circ_0007121	hsa_circ_None	-	DOID:10591	pre-eclampsia	preeclampsia	RT-qPCR	down-regulated	"Collectively, this study demonstrates the existence of dysregulated circRNAs in the placenta of preeclampsia patients and annotates their potential roles in the pathogenesis of the disease. Encouragingly, hsa_circ_0007121 was found to be a potential noninvasive biomarker for the prediction of preeclampsia."	2
Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506.	-	-	circRNA-000284	DOID:4362	cervical cancer	cervical cancer	microarray	up-regulated	"Finally, the tumor promoting effect of circRNA-000284 was abolished by co-expression of miR-506 mimics or Snail-2 silencing vector. In conclusion, circRNA-000284 promotes cell proliferation and invasion in cervical cancer, and may serve as a promising therapeutic target for cervical cancer patients."	1
Identification of differentially expressed circular RNAs during TGF-ss1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells.	-	-	chr5:90817794-90827570	DOID:1287	cardiovascular system disease	cardiovascular disease	"RT-qPCR, RNA-seq"	up-regulated	"Chr5:90817794|90827570, chr8:71336875|71337745, and chr6:22033342|22038870 were significantly up-regulated in TGF-beta1-treated rat CAEC. "	1
Identification of differentially expressed circular RNAs during TGF-ss1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells.	-	-	chr8:71336875-71337745	DOID:1287	cardiovascular system disease	cardiovascular disease	"RT-qPCR, RNA-seq"	up-regulated	"Chr5:90817794|90827570, chr8:71336875|71337745, and chr6:22033342|22038870 were significantly up-regulated in TGF-beta1-treated rat CAEC. "	1
Identification of differentially expressed circular RNAs during TGF-ss1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells.	-	-	chr6:22033342-22038870	DOID:1287	cardiovascular system disease	cardiovascular disease	"RT-qPCR, RNA-seq"	up-regulated	"Chr5:90817794|90827570, chr8:71336875|71337745, and chr6:22033342|22038870 were significantly up-regulated in TGF-beta1-treated rat CAEC. "	1
Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus.	-	-	circRNA.1030	DOID:9351	diabetes mellitus	gestational diabetes mellitus	"RT-qPCR, RNA-seq"	up-regulated	CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM.	1
Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus.	-	-	circRNA.5333	DOID:9351	diabetes mellitus	gestational diabetes mellitus	"RT-qPCR, RNA-seq"	up-regulated	CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM.	1
Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus.	-	-	circRNA.33299	DOID:9351	diabetes mellitus	gestational diabetes mellitus	"RT-qPCR, RNA-seq"	up-regulated	CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM.	1
Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus.	-	-	circRNA.20159	DOID:9351	diabetes mellitus	gestational diabetes mellitus	"RT-qPCR, RNA-seq"	down-regulated	CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM.	1
Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus.	-	-	circRNA.37134	DOID:9351	diabetes mellitus	gestational diabetes mellitus	"RT-qPCR, RNA-seq"	down-regulated	CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM.	1
Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus.	-	-	circRNA.22054	DOID:9351	diabetes mellitus	gestational diabetes mellitus	"RT-qPCR, RNA-seq"	down-regulated	CircRNAs are aberrantly expressed in the placental villi of GDM patients and play potential roles in the development of GDM.	1
A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911.	hsa_circ_0037911	hsa_circ_GSPT1	-	DOID:10825	essential hypertension	essential hypertension	RT-qPCR	up-regulated	Our findings suggested that higher expression hsa_circ_0037911 may be key circRNAs for EH development by changing the concentration of Scr and could be a stable biomarker for early diagnosis of EH.	2
circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.	-	mmu_circ_HECTD1	-	DOID:850	lung disease	pulmonary silicosis	RT-qPCR	up-regulated	Our findings reveal a potentially new function for the circHECTD1/HECTD1 pathway and suggest a possible mechanism of fibrosis in patients with pulmonary silicosis.	1
CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7.	hsa_circ_0000284	hsa_circ_HIPK3	-	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	up-regulated	"Taken together, our data indicate that circHIPK3 may have considerable potential as a prognostic biomarker in CRC, and support the notion that therapeutic targeting of the c-Myb/circHIPK3/miR-7 axis may be a promising treatment approach for CRC patients."	2
Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis.	-	hsa_circ_MAN2B2	-	DOID:1324	lung cancer	lung cancer	"RT-qPCR, microarray"	up-regulated	"Taken together, our study demonstrated that circMAN2B2 acts as an oncogenic role in lung cancer through promoting FOXK1 expression by sponging miR-1275."	1
Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.	hsa_circ_0000172	hsa_circ_CSRP1	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs."	1
Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.	hsa_circ_0002495	hsa_circ_RORA	-	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs."	1
Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.	-	-	Chr22: 28943661	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs."	1
Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.	-	-	Chr5: 158368701	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	up-regulated	"In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs."	1
Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.	-	-	Chr9: 74522734	DOID:11054	urinary bladder cancer	bladder cancer	"RT-qPCR, microarray"	down-regulated	"In summary, by investigating the differentially expressed circRNAs for clinical tumor samples, we have revealed a complex regulatory network for bladder cancer. The signaling pathways involved in the proliferation, metastasis, and transformation of the cancer are predicted to be subject to regulations of these differential circRNAs."	1
"Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1."	-	hsa_circ_PVT1	-	DOID:3347	osteosarcoma	osteosarcoma	RT-qPCR	up-regulated	These findings may provide a new insight into the role of circPVT1 as a biomarker for the diagnosis and treatment target of OS.	5
Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression.	hsa_circ_0014717	hsa_circ_CCT3	-	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	down-regulated	"Taken together, hsa_circ_0014717 acts as a potential tumor suppressor that inhibits CRC growth, partly at least, through upregulating p16 expression. Furthermore, our present study may provide a promising therapeutic target for CRC patients."	2
Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.	hsa_circ_0084927	hsa_circ_ESRP1	-	DOID:6543	acne	acne	"RT-qPCR, RNA-seq"	down-regulated	"Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018168) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis."	1
Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.	hsa_circ_0001073	hsa_circ_ACVR2A	-	DOID:6543	acne	acne	"RT-qPCR, RNA-seq"	down-regulated	"Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018169) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis."	1
Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.	hsa_circ_0005941	hsa_circ_FTO	-	DOID:6543	acne	acne	"RT-qPCR, RNA-seq"	down-regulated	"Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018170) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis."	1
Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.	hsa_circ_0086376	hsa_circ_NFIB	-	DOID:6543	acne	acne	"RT-qPCR, RNA-seq"	down-regulated	"Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018171) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis."	1
Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.	hsa_circ_0018168	hsa_circ_PARD3	-	DOID:6543	acne	acne	"RT-qPCR, RNA-seq"	down-regulated	"Five candidate circRNAs (circRNA_0084927, circRNA_0001073, circRNA_0005941, circRNA_0086376 and circRNA_0018172) were validated to have significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis."	1
Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis.	hsa_circ_0001859	hsa_circ_TCONS_l2_00028722	-	DOID:7148	rheumatoid arthritis	rheumatoid arthritis	RNA-seq	up-regulated	Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis.	1
Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities.	hsa_circ_0089810	hsa_circ_None	-	DOID:799	varicose veins	primary great saphenous vein varicosities	"RT-qPCR, RNA-seq"	down-regulated	"This study demonstrated that circRNAs were differentially expressed in PGSVVs, and highlights the crucial roles of circRNAs in the pathogenesis of PGSVVs and indicates that hsa_circ_0006427, hsa_circ_0089810 and hsa_circ_0005267 might be potential diagnostic and clinical biological markers."	1
Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities.	hsa_circ_0006427	hsa_circ_BCAR3	-	DOID:799	varicose veins	primary great saphenous vein varicosities	"RT-qPCR, RNA-seq"	down-regulated	"This study demonstrated that circRNAs were differentially expressed in PGSVVs, and highlights the crucial roles of circRNAs in the pathogenesis of PGSVVs and indicates that hsa_circ_0006427, hsa_circ_0089810 and hsa_circ_0005267 might be potential diagnostic and clinical biological markers."	1
Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities.	hsa_circ_0005267	hsa_circ_C14orf118	-	DOID:799	varicose veins	primary great saphenous vein varicosities	"RT-qPCR, RNA-seq"	down-regulated	"This study demonstrated that circRNAs were differentially expressed in PGSVVs, and highlights the crucial roles of circRNAs in the pathogenesis of PGSVVs and indicates that hsa_circ_0006427, hsa_circ_0089810 and hsa_circ_0005267 might be potential diagnostic and clinical biological markers."	1
The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma.	-	hsa_circ_PRKCI	-	DOID:1324	lung cancer	lung cancer	RT-qPCR	up-regulated	CircPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7 Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model.	3
Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.	hsa_circ_0011946	hsa_circ_SCMH1	-	DOID:1612	breast cancer	breast cancer	RNA-seq	up-regulated	"Together, these results indicate that hsa_circ_0011946 and RFC3 comprise a novel pathway involved in the progression of breast cancer."	1
Increased expression of circRNA_102231 in lung cancer and its clinical significance.	-	-	circRNA_102231	DOID:1324	lung cancer	lung cancer	"RT-qPCR, RNA-seq"	up-regulated	our study demonstrated that circRNA_102231 could act as a potential biomarker and therapeutic target for lung cancer patients.	1
Hsa_circ_0007534/miR-761/ZIC5 regulatory loop modulates the proliferation and migration of glioma cells.	hsa_circ_0007534	hsa_circ_DDX42	-	DOID:0060108	brain glioma	glioma	RT-qPCR	up-regulated	Our results suggested that hsa_circ_0007534/miR-761/ZIC5 regulatory loop might be a promising therapeutic target for glioma treatment.	2
Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients.	hsa_circ_0049224	hsa_circ_DNMT1	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	RT-qPCR	down-regulated	"Hsa_circ_0049224 and has_circ_0049220 are probable factors involved in the pathogenesis of SLE, and they have potential clinical value in SLE."	2
Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients.	hsa_circ_0049220	hsa_circ_DNMT1	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	RT-qPCR	down-regulated	"Hsa_circ_0049224 and has_circ_0049220 are probable factors involved in the pathogenesis of SLE, and they have potential clinical value in SLE."	2
Circular RNA circC3P1 suppresses hepatocellular carcinoma growth and metastasis through miR-4641/PCK1 pathway.	-	hsa_circ_C3P1	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	"RT-qPCR, RNA-seq"	down-regulated	our findings illustrated that circC3P1 acts as a tumor suppressor via enhancing PCK1 expression by sponging miR-4641 in HCC.	1
The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.	-	-	hsa_circ_100571	DOID:686	liver carcinoma	primary hepatic carcinoma	"RT-qPCR, microarray"	down-regulated	Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102347 is most likely to have association with primary hepatic carcinoma.	1
The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.	-	-	hsa_circ_400031	DOID:686	liver carcinoma	primary hepatic carcinoma	"RT-qPCR, microarray"	down-regulated	Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102348 is most likely to have association with primary hepatic carcinoma.	1
The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.	-	-	hsa_circ_102032	DOID:686	liver carcinoma	primary hepatic carcinoma	"RT-qPCR, microarray"	up-regulated	Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102349 is most likely to have association with primary hepatic carcinoma.	1
The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.	-	-	hsa_circ_103096	DOID:686	liver carcinoma	primary hepatic carcinoma	"RT-qPCR, microarray"	up-regulated	Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102350 is most likely to have association with primary hepatic carcinoma.	1
The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.	-	-	hsa_circ_102347	DOID:686	liver carcinoma	primary hepatic carcinoma	"RT-qPCR, microarray"	up-regulated	Five types of circular ribonucleic acid-related micro-ribonucleic acids had varying degrees of upregulation and downregulation between perioperative transplantation of primary hepatic carcinoma patients and normal controls; the hsa_circ_102351 is most likely to have association with primary hepatic carcinoma.	1
Identification of the tumor_suppressive function of circular RNA FOXO3 in non_small cell lung cancer through sponging miR_155.	-	hsa_circ_FOXO3	circRNA_FOXO3	DOID:3908	lung non-small cell carcinoma	non-small cell lung cancer	RT-qPCR	down-regulated	"These results suggest that circRNA_FOXO3 is a tumor_suppressor in NSCLC and may serve as a promising therapeutic target. Therefore, restoration of circRNA_FOXO3 expression could be a future approach to develop a novel treatment strategy."	2
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_000167	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	down-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_100433	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_101717	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_102049	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_102051	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_102619	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_103076	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_103390	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_104084	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Microarray expression profile analysis of circular RNAs in pancreatic cancer.	-	-	hsa_circRNA_104270	DOID:1793	pancreatic cancer	pancreatic cancer	"RT-qPCR, microarray"	up-regulated	The present study revealed that circRNAs expression was visibly diverse in pancreatic cancer compared with paracancerous tissue and provides more reliable biomarkers and new insights into the mechanisms of pancreatic cancer.	1
Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET.	hsa_circ_0000673	hsa_circ_RSL1D1	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	up-regulated	our findings demonstrated that hsa_circ_0000673 promoted HCC malignant behaviors via regulating miR-767-3p/SET pathway.	1
Down-regulation of hsa_circ_0001649 in hepatocellular carcinoma predicts a poor prognosis.	hsa_circ_0001649	hsa_circ_SHPRH	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RNA-seq	down-regulated	"Hsa_circ_0001649 could act as a novel prognostic biomarker for HCC patients. In addition, hsa_circ_ 0001649 might be a potential therapeutic target for HCC."	4
Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:3748	esophagus squamous cell carcinoma	esophageal squamous cell carcinoma	RT-qPCR	up-regulated	our study provided novel evidence that ciRS-7 accelerates ESCC progression by acting as a miR-876-5p sponge to enhance MAGE-A family expression.	4
Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.	-	-	hsa_circRNA_103827	DOID:3907	lung squamous cell carcinoma	lung squamous cell carcinoma	"RT-qPCR, microarray"	up-regulated	"Among these, hsa_circRNA_103827 and hsa_circRNA_000122 might be served as potential prognostic biomarkers and therapeutic target for LSCC."	1
Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.	-	-	hsa_circRNA_000122	DOID:3907	lung squamous cell carcinoma	lung squamous cell carcinoma	"RT-qPCR, microarray"	down-regulated	"Among these, hsa_circRNA_103827 and hsa_circRNA_000122 might be served as potential prognostic biomarkers and therapeutic target for LSCC."	1
Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia.	hsa_circ_0036877	hsa_circ_FURIN	-	DOID:10591	pre-eclampsia	preeclampsia	"RT-qPCR, microarray"	up-regulated	"Our study is the first systematic profiling of ceRNAs in placentas of PE patients and revealed the global ceRNA network integration in PE. Moreover, hsa_circ_0036877 can function as a ceRNA and serve as a potential novel blood biomarker for early PE."	2
Circular RNA circ-4099 is induced by TNF-alpha and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration.	-	-	circ-4099	DOID:90	degenerative disc disease	intervertebral disc degeneration	"RT-qPCR, microarray"	up-regulated	Circular RNA circ-4099 is induced by TNF-alpha and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration.	1
"Circular RNA circCDK13 suppresses cell proliferation, migration and invasion by modulating the JAK/STAT and PI3K/AKT pathways in liver cancer."	-	hsa_circ_CDK13	-	DOID:3571	liver cancer	liver cancer	RT-qPCR	down-regulated	"On the whole, the findings of this study indicate that circCDK13 is a novel circular RNA that suppresses liver cancer progression, and that these suppressive effects are possibly mediated via the JAK/STAT and PI3K/AKT signaling pathways."	1
Screening potential biomarkers for colorectal cancer based on circular RNA chips.	hsa_circ_0126897	hsa_circ_CBC1	-	DOID:9256	colorectal cancer	colorectal cancer	microarray	up-regulated	"hsa_circ_0126897_CBC1 may be a potential biomarker for CRC, and the cell cycle was closely associated with the occurrence and development of CRC."	1
"Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation."	-	-	circRNA_100284	DOID:684	hepatocellular carcinoma	malignant transformation of human hepatic cells	RT-qPCR	up-regulated	The findings support the concept that exosomal circRNAs are involved in cell-cell communication during carcinogenesis induced by arsenite.	1
Circular RNA circNASP modulates the malignant behaviors in osteosarcoma via miR-1253/FOXF1 pathway.	-	hsa_circ_NASP	-	DOID:3347	osteosarcoma	osteosarcoma	RT-qPCR	up-regulated	"Taken together, our findings demonstrated that circNASP contributes to malignant behaviors of OS cells by miR-1253/FOXF1 pathway, which suggested circNASP/miR-1253/FOXF1axis might be a potential therapeutic target."	1
"Circular RNA hsa-circ-0012129 Promotes Cell Proliferation and Invasion in 30 Cases of Human Glioma and Human Glioma Cell Lines U373, A172, and SHG44, by Targeting MicroRNA-661 (miR-661)."	hsa_circ_0012129	hsa_circ_B4GALT2	-	DOID:0060108	brain glioma	glioma	RT-qPCR	up-regulated	"The findings of this study indicated that, in human glioma cells, the circRNA, hsa-circ-0012129 might act as a natural miR-661 sponge, and that miR-661 could have suppressive effects on the expression of circ-0012129."	2
"Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis."	hsa_circ_0008344	hsa_circ_UBAP2	-	DOID:3073	brain glioblastoma multiforme	glioblastoma	"RT-qPCR, microarray"	up-regulated	Hsa_circ_0008344 is upregulated in glioblastoma and may contribute to the progression of this malignancy.	1
Hsa_circ_0079530 promotes cell proliferation and invasion in non-small cell lung cancer.	hsa_circ_0079530	hsa_circ_TWIST1	-	DOID:3908	lung non-small cell carcinoma	non-small cell lung cancer	RT-qPCR	up-regulated	These results indicated that hsa_circ_0075930 upregulation may be a critical oncogene and potential new biomarker in NSCLC.	3
Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia.	-	hsa_circ_PVT1	-	DOID:9952	acute lymphoblastic leukemia	acute lymphoblastic leukemia	RT-qPCR	up-regulated	CircPVT1 is upregulated in ALL. Silencing circPVT1 results in cell growth arrest and apoptosis of the cells. Our results also suggested a therapeutic potential of targeting circPVT1 in ALL.	2
CircRNA-Cdr1as Exerts Anti-Oncogenic Functions in Bladder Cancer by Sponging MicroRNA-135a.	hsa_circ_0001946	hsa_circ_CDR1	"ciRS-7, CDR1as"	DOID:11054	urinary bladder cancer	bladder cancer	RT-qPCR	down-regulated	Cdr1as is down-regulated and sponges multiple miRNAs in bladder cancer. It exerts anti-oncogenic functions by sponging microRNA-135a.	2
Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302.	-	-	hsa_circRNA_103809	DOID:1324	lung cancer	lung cancer	RT-qPCR	up-regulated	"In conclusion, our findings illustrated a novel hsa_circRNA_103809/miR-4302/ZNF121/MYC regulatory signaling pathway in lung cancer progression."	1
circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498.	-	hsa_circ_FADS2	hsa_circRNA_100833	DOID:1324	lung cancer	lung cancer	"RT-qPCR, microarray"	up-regulated	"Taken together, our findings indicated that circFADS2 was an effective tumor promoter in lung cancer progression, and its functions were performed by regulating the expression of miR-498. These data suggested that circFADS2 could act as a target for lung cancer treatment."	1
Differential Expression Profiles of Circular RNAs During Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells.	-	-	mmu_circRNA_013422	DOID:12347	osteogenesis imperfecta	osteogenesis	microarray	up-regulated	the circRNA-miRNA-mRNA pathways may provide information on novel mechanisms and targets for clinical investigations on bone formation and regeneration.	1
Differential Expression Profiles of Circular RNAs During Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells.	-	-	mmu_circRNA_22566	DOID:12347	osteogenesis imperfecta	osteogenesis	microarray	up-regulated	the circRNA-miRNA-mRNA pathways may provide information on novel mechanisms and targets for clinical investigations on bone formation and regeneration.	1
Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus.	hsa_circ_0045272	hsa_circ_ERN1	-	DOID:9074	systemic lupus erythematosus	systemic lupus erythematosus	"RT-qPCR, microarray"	down-regulated	Our study demonstrated dysregulated circRNAs in SLE and revealed the function of hsa_circ_0045272 in negatively regulating apoptosis and interleukin-2 secretion and its potential mechanism.	1
Circular RNA circMYO9B facilitates breast cancer cell proliferation and invasiveness via upregulating FOXP4 expression by sponging miR-4316.	-	hsa_circ_MYO9B	-	DOID:1612	breast cancer	breast cancer	RT-qPCR	up-regulated	"In conclusion, our findings demonstrated a key role of circMYO9B/miR-4316/FOXP4 axis in regulating BC progression."	1
CircRNF13 regulates the invasion and metastasis in lung adenocarcinoma by targeting miR-93-5p.	-	hsa_circ_RNF13	-	DOID:1324	lung cancer	lung cancer	RT-qPCR	down-regulated	Our data suggest that circRNF13 represents a potential novel biomarker and a therapeutic target of lung adenocarcinoma.	1
Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer disease-like rats using microarray analysis.	-	-	rno_circRNA_001555	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	up-regulated	Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs.	1
Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer disease-like rats using microarray analysis.	-	-	rno_circRNA_010684	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	up-regulated	Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs.	1
Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer disease-like rats using microarray analysis.	-	-	rno_circRNA_013981	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	down-regulated	Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs.	1
Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer disease-like rats using microarray analysis.	-	-	rno_circRNA_017759	DOID:10652	Alzheimer disease	Alzheimer disease	"RT-qPCR, microarray"	down-regulated	Our results suggest the involvement of different ncRNA expression patterns in the pathogenesis of AD. Our findings provide a novel perspective for further research into AD pathogenesis and might facilitate the development of novel therapeutics targeting ncRNAs.	1
Mm9_circ_009056 enhances osteogenesis by targeting BMP7 via CGRP-mediated miR-22-3p.	-	-	mm9_circ_009056	DOID:12347	osteogenesis imperfecta	enhances osteogenesis	"RT-qPCR, microarray"	up-regulated	mm9_circ_009056 may function as a sponge for miR-22-3p to regulate osteogenesis in CGRP-induced cells.	1
Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer.	-	hsa_circ_PDE8A	circ-PDE8A	DOID:3498	pancreatic ductal adenocarcinoma	pancreatic ductal adenocarcinoma	microarray	up-regulated	"Circ-PDE8A may play an important role in tumor invasion, and exosomal circ-PDE8A may be a useful marker of PDAC diagnosis or progression."	1
Emerging roles of hsa_circ_0005075 targeting miR-431 in the progress of HCC.	hsa_circ_0005075	hsa_circ_EIF4G3	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	up-regulated	These results suggest hsa_circ_0005075 promotes HCC via miR-431 regulation.	4
Hsa_circ_0071589 promotes carcinogenesis via the miR-600/EZH2 axis in colorectal cancer.	hsa_circ_0071589	hsa_circ_FAT1	-	DOID:9256	colorectal cancer	colorectal cancer	RT-qPCR	up-regulated	These results demonstrated that the hsa_circ_0071589/miR-600/EZH2 axis may play critical regulatory roles in the pathogenesis of CRC and may serve as a novel therapy target in CRC.	2
RNA-Seq profiling of circular RNAs in human laryngeal squamous cell carcinomas.	-	-	"hsa_circ:chr20:31876585-31,897,648"	DOID:2876	laryngeal squamous cell carcinoma	laryngeal squamous cell carcinoma	RT-qPCR	down-regulated	"Validation of down-regulation of hsa_circ:chr20:31876585-31,897,648 in LSCC compared to each adjunctive tissue by Q-RT-PCR, indicating that hsa_circ:chr20:31876585-31,897,648 may be a novel promising tumor suppresser in LSCC."	1
A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer.	-	hsa_circ_FARSA	-	DOID:3908	lung non-small cell carcinoma	non-small cell lung cancer	"RT-qPCR, RNA-seq"	up-regulated	"Summarily, this study revealed circRNA profile of NSCLC for the first time and provided the evidence of plasma circFARSA as a potential noninvasive biomarker for this malignancy."	2
"RNA-binding protein trinucleotide repeat-containing 6A regulates the formation of circular RNA circ0006916, with important functions in lung cancer cells."	-	-	circ0006916	DOID:1324	lung cancer	lung cancer	"RT-qPCR, microarray"	down-regulated	"These results demonstrate that TNRC6A regulates the biogenesis of the circRNA circ0006916, which has a regulatory role in cell growth."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_406841	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_000905	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_019252	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_089761	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_006050	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_074298	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_066556	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_101321	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_023016	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_019744	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	up-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_404686	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_000367	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_001729	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_004183	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_100790	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_104270	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_102049	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_406494	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_100787	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.	-	-	hsa_circRNA_082319	DOID:1781	thyroid gland cancer	thyroid cancer	microarray	down-regulated	"In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray."	1
Circular RNA hsa_circ_0023404 exerts an oncogenic role in cervical cancer through regulating miR-136/TFCP2/YAP pathway.	hsa_circ_0023404	hsa_circ_RNF121	-	DOID:4362	cervical cancer	cervical cancer	RT-qPCR	up-regulated	"Taken together, our study for the first time demonstrated the pivot role of hsa_circ_0023404 and revealed a novel regulatory loop of hsa_circ_0023404/miR-136/TFCP2/YAP axis in CC progression."	3
Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration.	-	hsa_circ_ZRANB1	-	DOID:8466	retinal degeneration	retinal neurodegeneration	RT-qPCR	up-regulated	cZRANB1 acts as miRNA sponge to regulate M¨šller cell function through cZRANB1/miR-217/RUNX2 network. Intervention of cZRANB1 expression would become an effective strategy for treating retinal neurodegeneration.	1
"CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia."	hsa_circ_0004904	hsa_circ_POLE2	-	DOID:10591	pre-eclampsia	preeclampsia	"RT-qPCR, microarray"	up-regulated	"This is the first study to report circRNA profiling in patients with PE prior to the onset of symptoms. Our data suggested that hsa_circ_0004904 and hsa_circ_0001855 combined with PAPP-A might be promising biomarkers for the detection of PE. Moreover, circRNAs may provide new insights into the potential mechanisms underlying the pathophysiology of PE."	1
"CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia."	hsa_circ_0001855	hsa_circ_RNF38	-	DOID:10591	pre-eclampsia	preeclampsia	"RT-qPCR, microarray"	up-regulated	"This is the first study to report circRNA profiling in patients with PE prior to the onset of symptoms. Our data suggested that hsa_circ_0004904 and hsa_circ_0001855 combined with PAPP-A might be promising biomarkers for the detection of PE. Moreover, circRNAs may provide new insights into the potential mechanisms underlying the pathophysiology of PE."	1
CircRNA_0023642 promotes migration and invasion of gastric cancer cells by regulating EMT.	hsa_circ_0023642	hsa_circ_UVRAG	circRNA_0023642	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	up-regulated	Our findings suggest that circRNA_0023642 serves as a metastasis activator by promoting EMT and may represent a novel molecular therapeutic target for GC.	2
circRNA_0084043 promote malignant melanoma progression via miR-153-3p/Snail axis.	hsa_circ_0084043	hsa_circ_ADAM9	circRNA_0084043	DOID:1909	melanoma	melanoma	microarray	up-regulated	"Overall, this result elucidates a new mechanism for circRNA_0084043 in melanoma development and provides a potential therapeutic target for melanoma patients."	3
"Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells."	hsa_circ_0066444	-	circ_0066444	DOID:10534	stomach cancer	gastric cancer	RT-qPCR	up-regulated	"Our study indicated upregulation of circ_0066444 promotes gastric cell proliferation, invasion, and migration ability and might serve as a novel biomarker for GC."	1
The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker.	hsa_circ_0001445	hsa_circ_SMARCA5	-	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	down-regulated	The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker.	3
Circular RNA 0068669 as a new biomarker for hepatocellular carcinoma metastasis.	hsa_circ_0068669	hsa_circ_SENP5	hsa_circ_103561	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	down-regulated	Our findings indicate that hsa_circ_0068669 might be served as a novel potential biomarker for HCC metastasis.	1
Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma.	hsa_circ_0137287	hsa_circ_SLC26A7	-	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	RT-qPCR	down-regulated	Our findings suggest that hsa_circ_0137287 may serve as a novel biomarker for PTC.	1
Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq.	-	-	hsa_circRNA001885	DOID:255	hemangioma	infantile hemangioma	RT-qPCR	up-regulated	our findings highlight the potential importance of circRNAs in the biology of IH and its response to treatment.	1
Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq.	-	-	hsa_circRNA006612	DOID:255	hemangioma	infantile hemangioma	RT-qPCR	up-regulated	our findings highlight the potential importance of circRNAs in the biology of IH and its response to treatment.	1
Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.	-	hsa_circ_CCNB1	circ-Ccnb1	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	down-regulated	These results shed light on the possible development of new approaches to inhibit the_alignancy of p53 mutations.	1
Circular RNA Myosin Light Chain Kinase (MYLK) Promotes Prostate Cancer Progression through Modulating Mir-29a Expression.	hsa_circ_0141940	hsa_circ_MYLK	circRNA-MYLK	DOID:10283	prostate cancer	prostate cancer	RT-qPCR	up-regulated	We confirmed circRNA-MYLK was an oncogene in PCa and revealed a novel mechanism underlying circRNA-MYLK in PC progression.	1
CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis.	-	hsa_circ_IRAK3	-	DOID:1612	breast cancer	breast cancer	"RT-qPCR, microarray"	up-regulated	"Intriguingly, FOXC1 could, in turn, bind to the IRAK3 promoter, triggering a positive-feedback loop that perpetuated the circIRAK3/miR-3607/FOXC1 signaling axis. Collectively, our findings indicated that circIRAK3 may exert regulatory roles in BC metastasis and may be a potential target for metastatic BC therapy."	2
"Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma."	hsa_circ_0000284	hsa_circ_HIPK3	-	DOID:3347	osteosarcoma	osteosarcoma	RT-qPCR	down-regulated	our data suggest that circ_HIPK3 may become a novel potential biomarker for diagnosis and treatment target of OS.	4
Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis.	hsa_circ_0008039	hsa_circ_PRKAR1B	-	DOID:1612	breast cancer	breast cancer	RT-qPCR	up-regulated	our study indicated that hsa_circ_0008039 exerted oncogenic roles in breast cancer and suggested the hsa_circ_0008039/miR-432-5p/E2F3 axis might be a potential therapeutic target.	2
Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression.	-	hsa_circ_ZFR	-	DOID:3969	thyroid gland papillary carcinoma	papillary thyroid cancer	RT-qPCR	up-regulated	Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression.	1
Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma.	-	hsa_circ_Cul2	circ-10720	DOID:684	hepatocellular carcinoma	hepatocellular carcinoma	RT-qPCR	up-