circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human esophageal cancer cell lines (Eca109, KYSE510, KYSE410, KYSE150)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HOXB13, p65
Associated microRNA: hsa-miR-7
Biological function: promote cell proliferation, migration and invasion in vitro as well as tumor growth and lung metastasis in vivo
Molecular mechanism: functioned as the sponge of hsa-miR-7 and reactivated its downstream HOXB13-mediated NF-kappaB/p65 pathway
Survival: poor
Supported No.:
 4
Description:

our findings demonstrate how ciRS-7 induces malignant progression of ESCC and that ciRS-7 may act as a novel prognostic marker and therapeutic target for this lethal disease.
Other information
Title:

CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13.

Journal: Cell Death Dis
Published: 2018/8/8
PubMed ID: 30082829