circRNA basic information
circBase ID: hsa_circ_0103809
Name: hsa_circ_AP4E1
Synonym: -
Host Gene: hsa-miR-490-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human liver cancer cell lines (MHCC97H, HepG2, Huh7, SMMC7721, SK-Hep1), normal liver cell line (HL-7702)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX2
Associated microRNA: hsa-miR-490-5p
Biological function: promotes cell proliferation and inhibits apoptosis
Molecular mechanism: targeting hsa-miR-490-5p/SOX2 signaling pathway
Survival: -
Supported No.:
 1
Description:

Our findings suggested that hsa_circ_0103809 might facilitate HCC malignant progression, at least partially, by regulating miR-490-5p/SOX2 signaling pathway.
Other information
Title:

Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway.

Journal: Am J Transl Res
Published: 2018/7/19
PubMed ID: 30018710