circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-193a
 
 
 
Disease basic information
DO ID:
 0070353
DO name: cataract
Disease details: age-related cataract
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: CRYAA
Associated microRNA: hsa-miR-193a
Biological function: The silencing of circHIPK3, but not HIPK3 mRNA, significantly accelerates apoptosis development upon oxidative stress and decreases cell viability and proliferation in primary cultured human lens epithelial cells (HLECs).
Molecular mechanism: targeting the hsa-miR-193a/CRYAA axis
Survival: -
Supported No.:
 3
Description:

This study suggests that circRNAs are the potential regulators in cataractogenesis. CircHIPK3 regulates HLECs function through miR-193a-mediated CRYAA expression. This finding would provide a novel insight into the pathogenesis of ARC.
Other information
Title:

Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis.

Journal: Biochem Biophys Res Commun
Published: 2018/7/1
PubMed ID: 29959922