circRNA basic information
circBase ID: -
Name: mmu_circ_HECTD1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: stroke
Species: mouse
Species details: mouse
Sample type: cell line
Sample type details: human astrocytoma cell line (A172)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: MIR142, TIPARP
Associated microRNA: -
Biological function: -
Molecular mechanism: circHECTD1 functions as an endogenous MIR142 (microRNA 142) sponge to inhibit MIR142 activity, resulting in the inhibition of TIPARP (TCDD inducible poly[ADP-ribose] polymerase) expression with subsequent inhibition of astrocyte activation via macroautophagy/autophagy.
Survival: -
Supported No.:
 1
Description:

CircHECTD1 functions as an endogenous MIR142 (microRNA 142) sponge to inhibit MIR142 activity, resulting in the inhibition of TIPARP (TCDD inducible poly[ADP-ribose] polymerase) expression with subsequent inhibition of astrocyte activation via macroautophagy/autophagy.
Other information
Title:

Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.

Journal: Autophagy
Published: 2018/6/26
PubMed ID: 29938598