circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: circular RNA-ZNF609
Host Gene: hsa-miR-615
 
 
 
Disease basic information
DO ID:
 8466
DO name: retinal degeneration
Disease details: retinal neurodegeneration
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: METRN
Associated microRNA: hsa-miR-615
Biological function: -
Molecular mechanism: cZNF609 acted as an endogenous hsa-miR-615 sponge to sequester and inhibit hsa-miR-615 activity, which led to increased METRN.
Survival: -
Supported No.:
 1
Description:

cZNF609 acted as an endogenous miR-615 sponge to sequester and inhibit miR-615 activity, which led to increased METRN. METRN overexpression could partially rescue cZNF609 silencing-mediated inhibitory effects on retinal glial cell proliferation.
Other information
Title:

Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge.

Journal: Theranostics
Published: 2018/6/23
PubMed ID: 29930739