circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-124
 
 
 
Disease basic information
DO ID:
 3121
DO name: gallbladder cancer
Disease details: gallbladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human gallbladder cancer cell lines (Mz-ChA-1, QBC939, GBC-SD)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK1, CDK6
Associated microRNA: hsa-miR-124
Biological function: promotes gallbladder cancer cell proliferation
Molecular mechanism: correlated with hsa-miR-124 downregulation and ROCK1-CDK6 upregulation
Survival: -
Supported No.:
 1
Description:

At last, we show that circHIPK3 is upregulated in human gallbladder cancer tissues, which is correlated with miR-124 downregulation and ROCK1-CDK6 upregulation. Together, we conclude that circHIPK3 promotes gallbladder cancer cell growth possibly by sponging miR-124. The over-expressed circHIPK3 could be a novel therapeutic target and diagnosis marker of human gallbladder cancer.
Other information
Title:

Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124.

Journal: Biochem Biophys Res Commun
Published: 2018/6/22
PubMed ID: 29928876