circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: cir-ITCH, circ-ITCH
Host Gene: hsa-miR-214
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human glioma cell lines (U87, U251, A172, SHG44, LN229, T98G, SHG139), normal glial cell line (M059K)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-214
Biological function: suppress the capacities of cell proliferation, migration and invasion
Molecular mechanism: sponging hsa-miR-214 and regulating ITCH-Wnt/beta-catenin pathway
Survival: better
Supported No.:
 1
Description:

the gain and loss functional assays indicate that cir-ITCH plays an anti-oncogenic role through sponging miR-214 and regulating ITCH-Wnt/beta-catenin pathway.
Other information
Title:

Identification of the tumor-suppressive function of circular RNA ITCH in glioma cells through sponging miR-214 and promoting linear ITCH expression.

Journal: Am J Transl Res
Published: 2018/6/12
PubMed ID: 29887952