circRNA basic information
circBase ID: -
Name: hsa_circ_IRAK3
Synonym: -
Host Gene: hsa-miR-3607
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF10A, T47D, MCF7, SK-BR-3, BT-474, MDA-MB-231, MDA-MB-157, MDA-MB-436, HCC70, HCC1806, HCC1937, BT-549, HEK-293T
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXC1
Associated microRNA: hsa-miR-3607
Biological function: promoted cell migration, invasion and metastasis
Molecular mechanism: circIRAK3/hsa-miR-3607/FOXC1 signaling axis
Survival: -
Supported No.:
 2
Description:

Intriguingly, FOXC1 could, in turn, bind to the IRAK3 promoter, triggering a positive-feedback loop that perpetuated the circIRAK3/miR-3607/FOXC1 signaling axis. Collectively, our findings indicated that circIRAK3 may exert regulatory roles in BC metastasis and may be a potential target for metastatic BC therapy.
Other information
Title:

CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis.

Journal: Cancer Lett
Published: 2018/5/29
PubMed ID: 29803789