circRNA basic information
circBase ID: -
Name: hsa_circ_CCNB1
Synonym: circ-Ccnb1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human non-cancer cell lines (Beas2B, 293T, HaCat, HGF, MCF10A), breast cancer cell lines (MCF7, ZR75, Skbr3, BT474, MB453, MB468, HTB126, MB231, Bom1833, BT549)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: Bclaf1, Bcl2, p53
Associated microRNA: -
Biological function: enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.
Molecular mechanism: In the p53 mutant cells, circ-Ccnb1 formed a complex with H2AX and Bclaf1, resulting in the induction of cell death.
Survival: -
Supported No.:
 1
Description:

These results shed light on the possible development of new approaches to inhibit the_alignancy of p53 mutations.
Other information
Title:

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.

Journal: Cell Death Differ
Published: 2018/5/26
PubMed ID: 29795334