circRNA basic information
circBase ID: hsa_circ_0023404
Name: hsa_circ_RNF121
Synonym: -
Host Gene: hsa-miR-136
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human cervical cancer cell lines (SiHa, C-33a, CaSki, C4-1, Hela), human cervical epithelial cells (CerEpiC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TFCP2, YAP
Associated microRNA: hsa-miR-136
Biological function: promote cell proliferative, migrated and invasive
Molecular mechanism: hsa_circ_0023404 activated YAP pathway in CC via promoting TFCP2 expression by sponging hsa-miR-136, leading to CC development and progression.
Survival: -
Supported No.:
 3
Description:

Taken together, our study for the first time demonstrated the pivot role of hsa_circ_0023404 and revealed a novel regulatory loop of hsa_circ_0023404/miR-136/TFCP2/YAP axis in CC progression.
Other information
Title:

Circular RNA hsa_circ_0023404 exerts an oncogenic role in cervical cancer through regulating miR-136/TFCP2/YAP pathway.

Journal: Biochem Biophys Res Commun
Published: 2018/5/9
PubMed ID: 29738762