circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Hep3B, HepG2, SMMC-7721, Bel7402, HL-7702
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCNE1 and PIK3CD
Associated microRNA: hsa-miR-7
Biological function: promoted proliferation and invasion
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 4
Description:

Knockdown of Cdr1as suppressed the expression of miR-7 and also inhibited the CCNE1 and PIK3CD expression. Furthermore, knockdown of Cdr1as suppressed the HCC cell proliferation and invasion through targeting miR-7.
Other information
Title:

The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression.

Journal: PLoS One
Published: 2016/7/9
PubMed ID: 27391479