circRNA basic information
circBase ID: -
Name: hsa_circ_NCX1
Synonym: -
Host Gene: hsa-miR-133a-3p
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: ischemic myocardial injury
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDIP1
Associated microRNA: hsa-miR-133a-3p
Biological function: promotes cardiomyocyte apoptosis
Molecular mechanism: Due to competitive binding of circNCX1 to hsa-miR-133a-3p, the suppressive activity of pro-apoptotic gene cell death-inducing protein (CDIP1) by hsa-miR-133a-3p was reduced
Survival: -
Supported No.:
 1
Description:

Our findings reveal a novel regulatory pathway that comprises circNCX1, miR-133a-3p and CDIP1, that is involved in cardiomyocyte apoptosis. This pathway may serve as a potential therapeutic avenue for ischemic heart diseases.
Other information
Title:

A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p.

Journal: Theranostics
Published: 2019/1/8
PubMed ID: 30613267