circRNA basic information
circBase ID: -
Name: hsa_circ_PDE8A
Synonym: circ-PDE8A
Host Gene: hsa-miR-338
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: cell line
Sample type details: pancreatic ductal adenocarcinoma cell lines (BxPC-3, Capan-1, Hs 766T, Hs 766T, Aspc-1, HEK-293)
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: MACC1, MET, ERK
Associated microRNA: hsa-miR-338
Biological function: promotes invasive growth
Molecular mechanism: acts as a ceRNA for hsa-miR-338 to regulate MACC1 and stimulates invasive growth via the MACC/MET/ERK or AKT pathways
Survival: poor
Supported No.:
 1
Description:

Circ-PDE8A may play an important role in tumor invasion, and exosomal circ-PDE8A may be a useful marker of PDAC diagnosis or progression.
Other information
Title:

Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer.

Journal: Cancer Lett
Published: 2018/5/2
PubMed ID: 29709702