circRNA basic information
circBase ID: -
Name: hsa_circ_FOXO3
Synonym: circRNA_FOXO3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: NSCLC adenocarcinoma cell lines (A549, SPC-A1, NCI-H1299, NCI-H1650), NSCLC squamous carcinomas cell line (SK-MES-1), normal human bronchial epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: sequestering miR_155, which further promoted linear FOXO3 expression
Survival: -
Supported No.:
 2
Description:

These results suggest that circRNA_FOXO3 is a tumor_suppressor in NSCLC and may serve as a promising therapeutic target. Therefore, restoration of circRNA_FOXO3 expression could be a future approach to develop a novel treatment strategy.
Other information
Title:

Identification of the tumor_suppressive function of circular RNA FOXO3 in non_small cell lung cancer through sponging miR_155.

Journal: Mol Med Rep
Published: 2018/4/6
PubMed ID: 29620202