circRNA basic information
circBase ID: hsa_circ_0011946
Name: hsa_circ_SCMH1
Synonym: -
Host Gene: hsa-miR-26a, hsa-miR-26b
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: breast cancer cell lines (HS-578T, T47D, MCF-7, BT549, MDA-MB-231, SKBR-3)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: RFC3
Associated microRNA: hsa-miR-26a, hsa-miR-26b
Biological function: promotes cell migration and invasion
Molecular mechanism: hsa_circ_0011946 sponging hsa-miR-26a/b directly targeted replication factor C subunit 3 (RFC3) and that its knockdown could inhibit RFC3 mRNA and protein expression
Survival: -
Supported No.:
 1
Description:

Together, these results indicate that hsa_circ_0011946 and RFC3 comprise a novel pathway involved in the progression of breast cancer.
Other information
Title:

Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.

Journal: Cancer Manag Res
Published: 2018/3/30
PubMed ID: 29593432