circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCI
Synonym: -
Host Gene: hsa-miR-545, hsa-miR-589
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: A549, NCI-H1975, NCI-H1703, NCI-H226, NCI-H46, PC9, NCI-H1299, 7 SPC-A1, HCC827, human bronchial epithelial cell (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F7
Associated microRNA: hsa-miR-545, hsa-miR-589
Biological function: promotes tumor growth
Molecular mechanism: circPRKCI functioned as a sponge for both hsa-miR-545 and hsa-miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7 Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth
Survival: -
Supported No.:
 3
Description:

CircPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7 Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model.
Other information
Title:

The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma.

Journal: Cancer Res
Published: 2018/3/29
PubMed ID: 29588350