circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: hsa-miR-7
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal colon epithelial cell (FHC), colorectal cancer cell lines (HCT116, HT29, SW480, SW620, DLD1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: c-Myb
Associated microRNA: hsa-miR-7
Biological function: promotes colorectal cancer growth and metastasis
Molecular mechanism: sponging hsa-miR-7
Survival: poor
Supported No.:
 2
Description:

Taken together, our data indicate that circHIPK3 may have considerable potential as a prognostic biomarker in CRC, and support the notion that therapeutic targeting of the c-Myb/circHIPK3/miR-7 axis may be a promising treatment approach for CRC patients.
Other information
Title:

CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7.

Journal: Cell Death Dis
Published: 2018/3/20
PubMed ID: 29549306