circRNA basic information
circBase ID: -
Name: hsa_circ_Sirt1
Synonym: Circ-Sirt1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 14557
DO name: primary pulmonary hypertension
Disease details: pulmonary arterial hypertension
Species: human
Species details: human
Sample type: PDX
Sample type details: PASMC
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: We found that the expression of circ-Sirt1 and SIRT1 decreased in the PAH rat model induced by hypoxia.
Molecular mechanism: It was also revealed that the overexpression of circ-SIRT1 increased SIRT1 levels, but inhibited the expression of transforming growth factor (TGF)-beta1, Smad3, and Smad7, and weakened PASMC cell vitality, proliferation, and migration ability.
Survival: -
Supported No.:
 1
Description:

The findings of the present study indicate that circ-Sirt1 regulates the expression of SIRT1 mRNA and inhibits TGF-beta1/Smad3/Smad7 mediated proliferation and migration of PASMC. This provides a new insight into the molecular mechanism of pulmonary artery vascular remodeling in PAH and may aid in the development of novel therapeutic options for management of PAH.
Other information
Title:

Evaluating the Effect of Circ-Sirt1 on the Expression of SIRT1 and Its Role in Pathology of Pulmonary Hypertension.

Journal: Cell Transplant
Published: 2022/3/1
PubMed ID: 35225027