circRNA basic information
circBase ID: hsa_circ_0085323
Name: -
Synonym: circ_0085323
Host Gene: hsa-miR-495-3p
 
 
 
Disease basic information
DO ID:
 8577
DO name: ulcerative colitis
Disease details: ulcerative colitis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NCM460 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRAF3
Associated microRNA: hsa-miR-495-3p
Biological function: Circ_0085323 knockdown relieved TNF-¦Á-induced inhibitory effect on the proliferation of NCM460 cells and promoting effects on cell apoptosis and inflammation.
Molecular mechanism: Circ_0085323 acted as a miR-495-3p sponge, and the effects of circ_0085323 silencing on TNF-¦Á-induced NCM460 cell injury were attenuated by decreasing miR-495-3p expression. TRAF3 was targeted by miR-495-3p, and circ_0085323 combined with miR-495-3p to regulate TRAF3.
Survival: -
Supported No.:
 2
Description:

Circ_0085323 knockdown ameliorated TNF-¦Á-induced NCM460 cell injury by regulating the miR-495-3p/TRAF3 axis, which suggested that circ_0085323 might be a therapeutic target for UC.
Other information
Title:

CIRC_0085323 SILENCING INHIBITS TNF-Alpha-INDUCED NORMAL HUMAN COLONIC EPITHELIAL CELL INFLAMMATION AND APOPTOSIS THROUGH THE MIR-495-3P/TRAF3 AXIS.

Journal: Shock
Published: 2023/8/22
PubMed ID: 37606890