circRNA basic information
circBase ID: hsa_circ_0001187
Name: hsa_circ_DOPEY2
Synonym: Hsa_circRNA_103124
Host Gene: hsa-miR-650
 
 
 
Disease basic information
DO ID:
 8778
DO name: Crohn disease
Disease details: Crohn disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: THP1 cells, HL60 cells, Caco2, HEK293T
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AKT2, TLR4, CD80, CD86, CD206, CD163
Associated microRNA: hsa-miR-650
Biological function: Hsa_circRNA_103124 promoted macrophage M1 polarization and promoted an inflammatory microenvironment
Molecular mechanism: NF-kappaB pathways
Survival: -
Supported No.:
 1
Description:

Hsa_circRNA_103124 could serve as a potential biomarker and a novel therapeutic target in CD progression.
Other information
Title:

Hsa_circRNA_103124 upregulation in Crohn disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-¦ĘB pathways

Journal: Int Immunopharmacol
Published: 2023/8/9
PubMed ID: 37567009