circRNA basic information
circBase ID: hsa_circ_0007379
Name: hsa_circ_SNX6
Synonym: Circ_0007379, circ7379
Host Gene: hsa-miR-320a
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal colonic epithelial cell line (FHC), human CRC cell lines (HT29, RKO, HCT116, SW480, SW620, LoVo, HCT8, LS123)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: RUNX1
Associated microRNA: hsa-miR-320a
Biological function: Circ_0007379 suppressed CRC cell growth and metastasis in cell culture as well as in patient-derived organoid and xenograft models
Molecular mechanism: Circ_0007379/hsa-miR-320a/RUNX1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Thus, our findings establish a previously unrecognized function of circRNA in inhibiting CRC progression.
Other information
Title:

Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner

Journal: Int J Biol Sci
Published: 2023/7/24
PubMed ID: 37564198