circRNA basic information
circBase ID: hsa_circ_0000370
Name: hsa_circ_FLI1
Synonym: circ_0000370
Host Gene: hsa-miR-502-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CRC cell lines (HCT116, SW480, SW620), human normal colon epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SIRT1
Associated microRNA: hsa-miR-502-5p
Biological function: Circ_0000370 depletion inhibited CRC cell proliferation, migration and invasion but induced cell apoptosis.
Molecular mechanism: Circ_0000370/hsa-miR-502-5p/SIRT1 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ_0000370 induced the proliferation and metastasis of CRC cells by sponging miR-502-5p and enhancing SIRT1 expression, which provided a possible target for CRC treatment.
Other information
Title:

Circ_0000370 Plays an Oncogenic Role in Colorectal Cancer by Regulating the miR-502-5p/SIRT1 Axis

Journal: Biochem Genet
Published: 2023/8/10
PubMed ID: 37561331