circRNA basic information
circBase ID: hsa_circ_0019170
Name: hsa_circ_EXOC6
Synonym: circEXOC6
Host Gene: hsa-miR-433-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human astrocytes (NHAs), glioma cells (T98G, LN229, U251, A172), endothelial cells (HCMEC/D3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD6
Associated microRNA: hsa-miR-433-3p
Biological function: Deficiency of circEXOC6 inhibited cell proliferation, migration, invasion, angiogenesis, and glycolysis, and triggered cell apoptosis ratio in glioma; simultaneously, it could block the growth of tumor in vivo.
Molecular mechanism: hsa-miR-433-3p/FZD6 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Deletion of circEXOC6 restrained cell progression and glycolysis by sponging miR-433-3p and interacting with FZD6, which might provide an underlying target for glioma treatment.
Other information
Title:

Knockdown of circEXOC6 inhibits cell progression and glycolysis by sponging miR-433-3p and mediating FZD6 in glioma

Journal: Transl Neurosci
Published: 2023/8/2
PubMed ID: 37554539