circRNA basic information
circBase ID: hsa_circ_0000106
Name: hsa_circ_CEPT1
Synonym: -
Host Gene: hsa-miR-455-3p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HDAC4
Associated microRNA: hsa-miR-455-3p
Biological function: Functionally, the proliferative and migratory properties of PC cells were dampened by the loss of circ_0000106 or HDAC4. Moreover, the knockdown of circ_0000106 delayed tumor growth in vivo.
Molecular mechanism: circ_0000106/hsa-miR-455-3p/HDAC4 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, circ_0000106 promotes tumor migration and growth in PC by targeting the miR-455-3p/HDAC4 axis. These results suggest that the circ 0000106/miR-455-3p/HDAC4 network could be regarded as a latent target for PC treatment.
Other information
Title:

Hsa_circ_0000106 Acts as a Tumor Promoter in Pancreatic Cancer by Targeting the MiR-455-3p/HDAC4

Journal: Horm Metab Res
Published: 2023/8/8
PubMed ID: 37553012