circRNA basic information
circBase ID: hsa_circ_0026920
Name: hsa_circ_SLC39A5
Synonym: circSLC39A5
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (SNU-423, SNU-449, MHCC97H, Huh7, Hep3B, HepG2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: MKI67, CD34, STAT1, TDG, PCNA
Associated microRNA: -
Biological function: CircSLC39A5 inhibited proliferation, migration, and invasion, facilitated the apoptosis of HCC cells
Molecular mechanism: circSLC39A5/STAT1/TDG/PCNA axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our findings uncovered a novel plasma circRNA, circSLC39A5, which may be a potential circulating diagnostic marker for HCC, and the mechanism by which nucleus-localized circSLC39A5 exerts a transcriptional regulatory role in HCC by affecting STAT1/TDG/PCNA provides new insights into the mechanism of circRNAs.
Other information
Title:

Nucleus-localized circSLC39A5 suppresses hepatocellular carcinoma development by binding to STAT1 to regulate TDG transcription

Journal: Cancer Sci
Published: 2023/8/7
PubMed ID: 37549641