circRNA basic information
circBase ID: hsa_circ_0006324
Name: hsa_circ_DENND1B
Synonym: Circ_0006324
Host Gene: hsa-miR-496
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (A549, H1975, H522, HCC827), human normal epithelial cell (BEAS-2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRIM59
Associated microRNA: hsa-miR-496
Biological function: Knockdown of circ_00006324 impeded NSCLC cell proliferation, glycolysis, and promoted cell apoptosis. Circ_0006324 knockdown impeded NSCLC tumor growth in vivo.
Molecular mechanism: Circ_0006324/hsa-miR-496/TRIM59 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0006324 functioned as a tumor promoter in NSCLC to promote cell proliferation, cell cycle progression, and glycolysis and inhibit cell apoptosis via miR-496/TRIM59 axis.
Other information
Title:

Circ_0006324 regulates cell proliferation, cell-cycle progression, apoptosis, and glycolysis of non-small cell lung cancer cells through miR-496/TRIM59 axis

Journal: J Biochem Mol Toxicol
Published: 2023/8/7
PubMed ID: 37545326