circRNA basic information
circBase ID: hsa_circ_0005774
Name: hsa_circ_CDK1
Synonym: CircCDK1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: LSCC cell lines (TU177and AMC-HN-8), NP69 (human normal nasopharyngeal cells), 293T cell lines
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: EIF4A3, SDC1, CPPED1
Associated microRNA: -
Biological function: The level of circCDK1 was positively correlated with poor prognosisof LSCC patients. In vitro and in vivo, circCDK1 promoted migration and invasion of LSCC cells.
Molecular mechanism: EIF4A3/circCDK1/IGF2BP2/CPPED1 axis
Survival: poor
Supported No.:
 1
Description:

Our findings demonstrated that EIF4A3-induced upregulation of circCDK1 promoted LSCC metastasis via EIF4A3-circCDK1-IGF2BP2-CPPED1 to activate PI3K-AKT signal pathway.
Other information
Title:

CircCDK1 blocking IGF2BP2-mediated m6A modification of CPPED1 promotes laryngeal squamous cell carcinoma metastasis via the PI3K/AKT signal pathway

Journal: Gene
Published: 2023/8/3
PubMed ID: 37543219