circRNA basic information
circBase ID: hsa_circ_0000119
Name: hsa_circ_MAN1A2
Synonym: circ_0000119
Host Gene: hsa-miR-433-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CC cells (CaSki, SiHa), control cells (Ect1, E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PAK2
Associated microRNA: hsa-miR-433-3p
Biological function: Knockdown of circ_0000119 inhibited CC cell proliferation, cell cycle progress, migration, invasion, and promoted apoptosis of CC cells. Moreover, circ_0000119 knockdown reduced tumor growth of CC in vivo.
Molecular mechanism: circ_0000119/hsa-miR-433-3p/PAK2 axis, miRNA sponge
Survival: poor
Supported No.:
 2
Description:

Circ_0000119 was upregulated in CC, and circ_0000119 knockdown suppressed CC malignant development through the miR-433-3p/PAK2 axis.
Other information
Title:

Circular RNA circ_0000119 promotes cervical cancer cell growth and migration via miR-433-3p/PAK2 axis

Journal: J Appl Genet
Published: 2023/8/4
PubMed ID: 37540462