circRNA basic information
circBase ID: hsa_circ_0070975
Name: hsa_circ_SLC7A11
Synonym: circSLC7A11
Host Gene: hsa-miR-877-5p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: LSCC cells TU686, AMC_HN_8 (with high invasion), human nasopharyngeal epithelial cells (NP69)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LASP1
Associated microRNA: hsa-miR-877-5p
Biological function: Functional studies revealed that circSLC7A11 knockdown reduced LSCC cell proliferation, migration, invasion, stemness characteristics, and enhanced cell apoptosis.
Molecular mechanism: circSLC7A11/hsa-miR-877-5p/LASP1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

CircSLC7A11 exerted oncogenic functions in LSCC by miR-877-5p/LASP1, hinting that circSLC7A11 was a novel biomarker for LSCC.
Other information
Title:

Circular RNA circSLC7A11 contributes to progression and stemness of laryngeal squamous cell carcinoma via sponging miR-877-5p from LASP1

Journal: Heliyon
Published: 2023/7/14
PubMed ID: 37539185