circRNA basic information
circBase ID: hsa_circ_0000235
Name: hsa_circ_CCNY
Synonym: Circ_0000235, circ235
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human-derived Bca cell lines (T24, UMUC3, EJ), human bladder epithelial cells (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MCT4
Associated microRNA: hsa-miR-330-5p
Biological function: In vitro studies revealed that circ235 accelerated the rate of extracellular acidification and promoted glucose uptake and lactate manufacture in Bca cells. Additionally, it strengthened the proliferative and migratory capacities. Experiments on animals revealed that downregulating circ235 dramatically reduced carcinogenesis and tumor growth.
Molecular mechanism: Circ235/hsa-miR-330-5p/MCT4 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

In conclusion, these findings suggest that circ235 may be a viable molecular marker and therapeutic target for Bca.
Other information
Title:

Circ_0000235 targets MCT4 to promote glycolysis and progression of bladder cancer by sponging miR-330-5p

Journal: Cell Death Discov
Published: 2023/8/2
PubMed ID: 37532687