circRNA basic information
circBase ID: hsa_circ_0001472
Name: hsa_circ_NIPBL
Synonym: circNIPBL
Host Gene: hsa-miR-16-2-3p
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bladder cancer cell lines (T24, UM-UC-3, 5637), human normal bladder epithelial cell line (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Wnt5a, ZEB1
Associated microRNA: hsa-miR-16-2-3p
Biological function: Functionally, circNIPBL promotes BCa metastasis in vitro and in vivo.
Molecular mechanism: circNIPBL/hsa-miR-16-2-3p/Wnt5a/ZEB1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Our study highlights that circNIPBL-induced Wnt signaling pathway activation triggers ZEB1-mediated circNIPBL biogenesis, which forms a positive feedback loop via the circNIPBL/miR-16-2-3p/Wnt5a/ZEB1 axis, supporting circNIPBL as a novel therapeutic target and potential biomarker for BCa patients.
Other information
Title:

ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/beta-catenin pathway

Journal: J Exp Clin Cancer Res
Published: 2023/8/2
PubMed ID: 37528489