circRNA basic information
circBase ID: hsa_circ_0017639
Name: hsa_circ_SFMBT2
Synonym: circRNA-SFMBT2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Primary human myobla
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: QKI, RNF181
Associated microRNA: -
Biological function: The high circRNA-SFMBT2 levels were related to larger tumor size and poor prognosis in patients with ER+ breast cancer. The biologically elevated circRNA-SFMBT2 expression promoted cell growth and tamoxifen resistance in ER+ breast cancer
Molecular mechanism: ERalpha signaling
Survival: poor
Supported No.:
 1
Description:

In summary, circRNA-SFMBT2 is an important regulator of ERalpha signaling, and antagonizing circRNA-SFMBT2 expression may constitute a potential therapeutic strategy for breast cancer.
Other information
Title:

circRNA-SFMBT2 orchestrates ERalpha activation to drive tamoxifen resistance in breast cancer cells

Journal: Cell Death Dis
Published: 2023/7/31
PubMed ID: 37524698