circRNA basic information
circBase ID: hsa_circ_0077892
Name: hsa_circ_TBPL1
Synonym: circTBPL1
Host Gene: hsa-miR-653-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: breast cancer cell lines (MDA-MB-231, MDA-MB-468)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TPBG
Associated microRNA: hsa-miR-653-5p
Biological function: The exosomal circTBPL1 from CAFs could be transferred to breast cancer cells and promoted cell proliferation, migration, and invasion. Consistently, circTBPL1 knockdown in CAFs attenuated their tumor-promoting ability.
Molecular mechanism: circTBPL1/hsa-miR-653-5p/TPBG axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, these results revealed that exosomal circTBPL1 derived from CAFs contributed to cancer progression via miR-653-5p/TPBG pathway, indicating the potential of exosomal circTBPL1 as a biomarker and novel therapeutic target for breast cancer.
Other information
Title:

Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication

Journal: Cell Death Dis
Published: 2023/7/26
PubMed ID: 37495592