circRNA basic information
circBase ID: hsa_circ_0003146
Name: hsa_circ_EHD2
Synonym: circEHD2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: All human RCC cell lines (OSRC-2, 786-O, Caki-1, 769-P), human renal proximal tubular epithelial cell line (HK2), mouse RCC cell line Renca, fibroblast cell line MRC5, human embryonic kidney 293T cell line
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YWHAH, YAP, SOX9
Associated microRNA: -
Biological function: Silencing circEHD2 inhibited tumor growth in vitro and in vivo.
Molecular mechanism: circEHD2/YWHAH/YAP/SOX9 axis
Survival: -
Supported No.:
 2
Description:

The circEHD2/YWHAH/YAP/SOX9 signaling pathway accelerates the growth of RCC.
Other information
Title:

Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts

Journal: Mol Cancer
Published: 2023/7/22
PubMed ID: 37481520