circRNA basic information
circBase ID: hsa_circ_0005224
Name: hsa_circ_TGFBR2
Synonym: circTGFBR2
Host Gene: hsa-miR-205-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cells (Hep3B, Huh7), human hepatocytes (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ATG5
Associated microRNA: hsa-miR-205-5p
Biological function: Enhance autophagy in HCC cells, resulting in resistance to starvation
Molecular mechanism: circTGFBR2/hsa-miR-205-5p/ATG5 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Thus, we revealed that circTGFBR2 is a novel tumor promoter circRNA in hepatocytic exosomes and promotes HCC progression by enhancing ATG5-mediated protective autophagy via the circTGFBR2/miR-205-5p/ATG5 axis, which may be a potential therapeutic target for HCC.
Other information
Title:

Exosomal circTGFBR2 promotes hepatocellular carcinoma progression via enhancing ATG5 mediated protective autophagy

Journal: Cell Death Dis
Published: 2023/7/20
PubMed ID: 37474520